Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report

Qin,You‑Wen; Yang,Yi‑Ning; Bai,Ping; Wang,Chun

doi:10.3892/ol.2016.4505

Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report

Authors:
- You‑Wen Qin
- Yi‑Ning Yang
- Ping Bai
- Chun Wang
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Affiliations: Department of Hematology, Shanghai First People's Hospital, Medical College, Shanghai Jiaotong University, Shanghai 200080, P.R. China, Clinical Laboratory, Shanghai First People's Hospital, Medical College, Shanghai Jiaotong University, Shanghai 200080, P.R. China
Published online on: April 27, 2016 https://doi.org/10.3892/ol.2016.4505
Pages: 4131-4133

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Abstract

t(8;22)(p11;q11) is a rare but recurrent genetic alteration in various hematological disorders. Patients with t(8;22)(p11;q11) may be misdiagnosed with chronic myelogenous leukemia (CML), due to the similar clinical features. Thus, the current study presents a patient with t(8;22)(p11;q11) who was previously misdiagnosed with CML in the chronic phase. The current patient was a 26‑year‑old woman who was 4-weeks pregnant and in whom an increased white blood cell count (4.0x1010/l) was found upon physical examination. The patient had no history of hematological disease. Although cytogenetics showed a normal karyotype and no breakpoint cluster region/Abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) fusion gene was detected by reverse transcription‑polymerase chain reaction, a diagnosis of chronic myelogenous leukemia (CML) was initially made according to the clinical and morphological features. Another 6 weeks later, t(8;22)(p11;q11) rearrangement was present in 9 out of 10 analyzed metaphases. Fluorescence in situ hybridization and reverse transcription‑polymerase chain reaction indicated a negative result for the BCR/ABL fusion, but gave a positive result for the BCR‑fibroblast growth factor receptor 1 fusion. A hematological diagnosis of atypical CML was again formed.

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