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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June-2016 Volume 11 Issue 6

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Case Report

Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report

  • Authors:
    • You‑Wen Qin
    • Yi‑Ning Yang
    • Ping Bai
    • Chun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Shanghai First People's Hospital, Medical College, Shanghai Jiaotong University, Shanghai 200080, P.R. China, Clinical Laboratory, Shanghai First People's Hospital, Medical College, Shanghai Jiaotong University, Shanghai 200080, P.R. China
  • Pages: 4131-4133
    |
    Published online on: April 27, 2016
       https://doi.org/10.3892/ol.2016.4505
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Abstract

t(8;22)(p11;q11) is a rare but recurrent genetic alteration in various hematological disorders. Patients with t(8;22)(p11;q11) may be misdiagnosed with chronic myelogenous leukemia (CML), due to the similar clinical features. Thus, the current study presents a patient with t(8;22)(p11;q11) who was previously misdiagnosed with CML in the chronic phase. The current patient was a 26‑year‑old woman who was 4-weeks pregnant and in whom an increased white blood cell count (4.0x1010/l) was found upon physical examination. The patient had no history of hematological disease. Although cytogenetics showed a normal karyotype and no breakpoint cluster region/Abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) fusion gene was detected by reverse transcription‑polymerase chain reaction, a diagnosis of chronic myelogenous leukemia (CML) was initially made according to the clinical and morphological features. Another 6 weeks later, t(8;22)(p11;q11) rearrangement was present in 9 out of 10 analyzed metaphases. Fluorescence in situ hybridization and reverse transcription‑polymerase chain reaction indicated a negative result for the BCR/ABL fusion, but gave a positive result for the BCR‑fibroblast growth factor receptor 1 fusion. A hematological diagnosis of atypical CML was again formed.
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Copy and paste a formatted citation
Spandidos Publications style
Qin YW, Yang YN, Bai P and Wang C: Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report. Oncol Lett 11: 4131-4133, 2016.
APA
Qin, Y., Yang, Y., Bai, P., & Wang, C. (2016). Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report. Oncology Letters, 11, 4131-4133. https://doi.org/10.3892/ol.2016.4505
MLA
Qin, Y., Yang, Y., Bai, P., Wang, C."Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report". Oncology Letters 11.6 (2016): 4131-4133.
Chicago
Qin, Y., Yang, Y., Bai, P., Wang, C."Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report". Oncology Letters 11, no. 6 (2016): 4131-4133. https://doi.org/10.3892/ol.2016.4505
Copy and paste a formatted citation
x
Spandidos Publications style
Qin YW, Yang YN, Bai P and Wang C: Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report. Oncol Lett 11: 4131-4133, 2016.
APA
Qin, Y., Yang, Y., Bai, P., & Wang, C. (2016). Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report. Oncology Letters, 11, 4131-4133. https://doi.org/10.3892/ol.2016.4505
MLA
Qin, Y., Yang, Y., Bai, P., Wang, C."Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report". Oncology Letters 11.6 (2016): 4131-4133.
Chicago
Qin, Y., Yang, Y., Bai, P., Wang, C."Chronic myelogenous leukemia-like hematological malignancy with t(8;22) in a 26-year-old pregnant woman: A case report". Oncology Letters 11, no. 6 (2016): 4131-4133. https://doi.org/10.3892/ol.2016.4505
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