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Review

miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review)

  • Authors:
    • Xuexiang Liu
    • Jinwan Li
    • Fengxian Qin
    • Shengming Dai
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Science, The Fourth Hospital Affiliated to Guangxi Medical University, Liuzhou, Guangxi 545005, P.R. China
  • Pages: 3911-3916
    |
    Published online on: April 28, 2016
       https://doi.org/10.3892/ol.2016.4509
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Abstract

MicroRNAs (miRNAs or miRs) are endogenous translation repressors of protein-coding genes that act by binding to the 3'-untranslated region of their target genes, and may contribute to tumorigenesis by functioning as oncogenes or tumor suppressor genes. miR‑152, a member of the miR-148/152 family, is aberrantly expressed in various diseases, including various types of cancer. A growing body of evidence has demonstrated that miR‑152 may act as a tumor suppressor gene by regulating its target genes, which are associated with cell proliferation, migration and invasion in human cancer. In the present review, the gene structure and functions of miR‑152 are discussed, and in particular, its regulatory mechanism, experimentally validated targets and tumor suppressor role in cancer, are highlighted.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Li , Qin F and Dai S: miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review). Oncol Lett 11: 3911-3916, 2016.
APA
Liu, X., Li, ., Qin, F., & Dai, S. (2016). miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review). Oncology Letters, 11, 3911-3916. https://doi.org/10.3892/ol.2016.4509
MLA
Liu, X., Li, ., Qin, F., Dai, S."miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review)". Oncology Letters 11.6 (2016): 3911-3916.
Chicago
Liu, X., Li, ., Qin, F., Dai, S."miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review)". Oncology Letters 11, no. 6 (2016): 3911-3916. https://doi.org/10.3892/ol.2016.4509
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Li , Qin F and Dai S: miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review). Oncol Lett 11: 3911-3916, 2016.
APA
Liu, X., Li, ., Qin, F., & Dai, S. (2016). miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review). Oncology Letters, 11, 3911-3916. https://doi.org/10.3892/ol.2016.4509
MLA
Liu, X., Li, ., Qin, F., Dai, S."miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review)". Oncology Letters 11.6 (2016): 3911-3916.
Chicago
Liu, X., Li, ., Qin, F., Dai, S."miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer (Review)". Oncology Letters 11, no. 6 (2016): 3911-3916. https://doi.org/10.3892/ol.2016.4509
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