T cell receptor rearrangements in a patient with γ-heavy chain disease: A case report

Zhou,Hebing; Chen,Wenming; Zhang,Juan; Zeng,Hui; Jian,Yuan; Fu,Chenxiao

doi:10.3892/ol.2016.4515

T cell receptor rearrangements in a patient with γ-heavy chain disease: A case report

Authors:
- Hebing Zhou
- Wenming Chen
- Juan Zhang
- Hui Zeng
- Yuan Jian
- Chenxiao Fu
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Affiliations: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China, Department of Hematology, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100021, P.R. China
Published online on: May 4, 2016 https://doi.org/10.3892/ol.2016.4515
Pages: 4147-4151

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Abstract

Heavy chain diseases (HCDs) are rare B cell lymphoplasma cell proliferative disorders that are characterized by the production of incomplete monoclonal immunoglobulin (Ig) heavy chains without the associated light chains. γ-HCD (IgG subtype) is a rare subtype, with ~150 cases reported in the literature to date; however, to the best of our knowledge, no reports of T cell receptor (TCR) gene rearrangement in γ‑HCD exist in the literature. The present study reports the case of an 81‑year‑old man with γ-heavy chain disease associated with TCR gene rearrangement, identified in lymph node biopsy and bone marrow aspirate specimens. The present case revealed an alternative manifestation of γ-HCD, which may provide additional biological insights into this rare B cell disorder.

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