Myeloid sarcoma derived from the gastrointestinal tract: A case report and review of the literature

Yu,Teng; Xu,Genbo; Xu,Xiaohua; Yang,Jing; Ding,Luyin

doi:10.3892/ol.2016.4517

Myeloid sarcoma derived from the gastrointestinal tract: A case report and review of the literature

Authors:
- Teng Yu
- Genbo Xu
- Xiaohua Xu
- Jing Yang
- Luyin Ding
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Affiliations: Department of Hematology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
Published online on: May 4, 2016 https://doi.org/10.3892/ol.2016.4517
Pages: 4155-4159

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Abstract

Myeloid sarcoma is a type of malignant neoplasm composed of myeloblasts that locates extramedullary. The present study reports the case of a 31‑year‑old female who presented with upper abdominal pain, melena, vomiting and jaundice. The abdominal computed tomography revealed a mass in gastric antrum area and possible infiltration of the duodenum, gallbladder and head of the pancreas, with possible retroperitoneal lymph node metastasis. The tumor grew quickly and led to serious obstructive jaundice. New masses developed in the bilateral orbits and left breast within 2 months of admission. The pathological results of the gastroscopic biopsy and the fine‑needle biopsy of the breast revealed myeloid sarcoma. Transhepatic cholangial drainage, radiotherapy and chemotherapy were administered, but the disease reoccurred and became resistant to chemotherapy, so salvage allogenetic peripheral blood stem cell transplantation was performed. The disease relapsed at 5 months post‑transplantation, and chemotherapy and donor lymphocytes transfusions were then administered. The patient declined further treatment and succumbed to disease on May 19, 2015. The present study could improve the understanding of myeloid sarcoma and provide a reference for standardized and individualized treatments for this disease.

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1.	Vardiman JW: The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: An overview with emphasis on the myeloid neoplasms. Chem Biol Interact. 184:16–20. 2010. View Article : Google Scholar : PubMed/NCBI
2.	Pantanowitz L and Thompson L: Myeloid sarcoma. Ear Nose Throat J. 84:470–471. 2005.PubMed/NCBI
3.	Pileri SA, Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M, Piccaluga PP, Agostinelli C, Asioli S, Novero D, et al: Myeloid sarcoma: Clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 21:340–350. 2007. View Article : Google Scholar : PubMed/NCBI
4.	Narayan P, Murthy V, Su M, Woel R, Grossman IR and Chamberlain RS: Primary myeloid sarcoma masquerading as an obstructing duodenal carcinoma. Case Rep Hematol. 2012:4904382012.PubMed/NCBI
5.	Shimizu H, Saitoh T, Hatsumi N, Takada S, Yokohama A, Handa H, Jimbo T, Sakura T, Tsukamoto N, Murakami H, et al: Clinical significance of granulocytic sarcoma in adult patients with acute myeloid leukemia. Cancer Sci. 103:1513–1517. 2012. View Article : Google Scholar : PubMed/NCBI
6.	Haferlach C, Bacher U, Grossmann V, Schindela S, Zenger M, Kohlmann A, Kern W, Haferlach T and Schnittger S: Three novel cytogenetically cryptic EVI1 rearrangements associated with increased EVI1 expression and poor prognosis identified in 27 acute myeloid leukemia cases. Genes Chromosomes Cancer. 51:1079–1085. 2012. View Article : Google Scholar : PubMed/NCBI
7.	Li JM, Liu WP, Zhang MH, Wei X, Gu JM, Han AJ, Wu WQ and Chen XY: Clinicopathologic and immunophenotypic analysis of myeloid sarcoma. Zhonghua Bing Li Xue Za Zhi. 35:606–611. 2006.(In Chinese). PubMed/NCBI
8.	Mourad W, Kfoury H and Al Husseini H: The value of CD34, myeloperoxidase and chloroacetate esterase (Leder) stain in the diagnosis of granulocytic sarcoma. Ann Saudi Med. 21:287–291. 2001.PubMed/NCBI
9.	Traweek ST, Arber DA, Rappaport H and Brynes RK: Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol. 17:1011–1019. 1993. View Article : Google Scholar : PubMed/NCBI
10.	Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T and Diebold J: Myeloid sarcoma: Clinical and morphologic criteria useful for diagnosis. Int J Surg Pathol. 11:271–282. 2003. View Article : Google Scholar : PubMed/NCBI
11.	Amador-Ortiz C, Hurley MY, Ghahramani GK, Frisch S, Klco JM, Lind AC, Nguyen TT, Hassan A, Kreisel FH and Frater JL: Use of classic and novel immunohistochemical markers in the diagnosis of cutaneous myeloid sarcoma. J Cutan Pathol. 38:945–953. 2011. View Article : Google Scholar : PubMed/NCBI
12.	Xavier SG, Fagundes EM, Hassan R, Bacchi C, Conchon M, Tabak DG, Spector N and Zalcberg IR: Granulocytic sarcoma of the small intestine with CBFbeta/MYH11 fusion gene: Report of an aleukaemic case and review of the literature. Leuk Res. 27:1063–1066. 2003. View Article : Google Scholar : PubMed/NCBI
13.	Skalska-Sadowska J, Januszkiewicz-Lewandowska D, Derwich K, Pieczonka A, Samborska M and Wachowiak J: Ph-negative isolated myeloid sarcoma with NPM1 gene mutation in adolescent with Ph-positive chronic myeloid leukemia in remission after treatment with allogeneic bone marrow transplantation and imatinib mesylate. Pediatr Blood Cancer. 62:1070–1071. 2015. View Article : Google Scholar : PubMed/NCBI
14.	Deeb G, Baer MR, Gaile DP, Sait SN, Barcos M, Wetzler M, Conroy JM, Nowak NJ, Cowell JK and Cheney RT: Genomic profiling of myeloid sarcoma by array comparative genomic hybridization. Genes Chromosomes Cancer. 44:373–383. 2005. View Article : Google Scholar : PubMed/NCBI
15.	Menasce LP, Banerjee SS, Beckett E and Harris M: Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: A study of 26 cases. Histopathology. 34:391–398. 1999. View Article : Google Scholar : PubMed/NCBI
16.	Movassaghian M, Brunner AM, Blonquist TM, Sadrzadeh H, Bhatia A, Perry AM, Attar EC, Amrein PC, Ballen KK, Neuberg DS and Fathi AT: Presentation and outcomes among patients with isolated myeloid sarcoma: A surveillance, epidemiology and end results database analysis. Leuk Lymphoma. 56:1698–1703. 2015. View Article : Google Scholar : PubMed/NCBI
17.	Yamauchi K and Yasuda M: Comparison in treatments of nonleukemic granulocytic sarcoma: Report of two cases and a review of 72 cases in the literature. Cancer. 94:1739–1746. 2002. View Article : Google Scholar : PubMed/NCBI
18.	He J, Zhu L, Ye X, Li L, Zhu J, Zhang J, Xie W, Shi J, Zheng W, Wei G, et al: Clinical characteristics and prognosis of nonleukemic myeloid sarcoma. Am J Med Sci. 347:434–438. 2014. View Article : Google Scholar : PubMed/NCBI
19.	Chelly I, Mekni A, Kchir N, Karim BH, Khadija B, Selma B, Slim H, Khaldi M and Zitouna M: Intracerebellar granulocytic sarcoma. A case report. Pathologica. 97:335–337. 2005.PubMed/NCBI
20.	Tsimberidou AM, Kantarjian HM, Wen S, Keating MJ, O'Brien S, Brandt M, Pierce S, Freireich EJ, Medeiros LJ and Estey E: Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. Cancer. 113:1370–1378. 2008. View Article : Google Scholar : PubMed/NCBI
21.	Widhalm G, Dietrich W, Müllauer L, Streubel B, Rabitsch W, Kotter MR, Knosp E and Roessler K: Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. J Neurosurg. 105:916–919. 2006. View Article : Google Scholar : PubMed/NCBI
22.	Chevallier P, Mohty M, Lioure B, Michel G, Contentin N, Deconinck E, Bordigoni P, Vernant JP, Hunault M, Vigouroux S, et al: Allogeneic hematopoietic stem-cell transplantation for myeloid sarcoma: A retrospective study from the SFGM-TC. J Clin Oncol. 26:4940–4943. 2008. View Article : Google Scholar : PubMed/NCBI
23.	Yagi T, Ishikawa J, Takahashi M, Yamashita Y, Kusakabe S, Yoshinami T, Masaie H, Sugimoto N, Yoshida H and Imamura F: Successful treatment of duodenal myeloid sarcoma with allogeneic bone marrow transplantation and additional radiotherapy. Intern Med. 51:769–772. 2012. View Article : Google Scholar : PubMed/NCBI