Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report

Pan,Ying; Wang,Chunhuai; Wang,Huiping; Tao,Qianshan; Xiong,Shudao; Zhai,Zhimin

doi:10.3892/ol.2016.4519

June-2016 Volume 11 Issue 6

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June-2016 Volume 11 Issue 6

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Case Report

Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report

Authors:
- Ying Pan
- Chunhuai Wang
- Huiping Wang
- Qianshan Tao
- Shudao Xiong
- Zhimin Zhai
View Affiliations / Copyright

Affiliations: Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China
Pages: 4066-4068
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Published online on: May 4, 2016

https://doi.org/10.3892/ol.2016.4519
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Abstract

Paraplegia following spinal injury is a rare complication subsequent to the administration of intrathecal chemotherapy; however, it is also one of the rare clinical features of central nervous system leukemia (CNSL). Distinguishing between the two is extremely important. The present study reports the case of a 46‑year‑old man who was diagnosed with acute lymphoblastic leukemia and subsequently achieved remission in the blood and bone marrow following the initial course of chemotherapy. However, the patient developed a sudden onset of paraplegia and urinary retention due to spinal cord infiltration of leukemia cells following the administration of intrathecal methotrexate and cytarabine. The paraplegia was initially reversible. However, a few weeks later, the patient developed irreversible paraplegia due to a complication of the intrathecal administration of chemotherapy (methotrexate and cytarabine arabinoside). The patient gave up further treatment in May 2013 and succumbed to the disease in June 2013.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report

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