Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report

  • Authors:
    • Ying Pan
    • Chunhuai Wang
    • Huiping Wang
    • Qianshan Tao
    • Shudao Xiong
    • Zhimin Zhai
  • View Affiliations

  • Published online on: May 4, 2016     https://doi.org/10.3892/ol.2016.4519
  • Pages: 4066-4068
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Abstract

Paraplegia following spinal injury is a rare complication subsequent to the administration of intrathecal chemotherapy; however, it is also one of the rare clinical features of central nervous system leukemia (CNSL). Distinguishing between the two is extremely important. The present study reports the case of a 46‑year‑old man who was diagnosed with acute lymphoblastic leukemia and subsequently achieved remission in the blood and bone marrow following the initial course of chemotherapy. However, the patient developed a sudden onset of paraplegia and urinary retention due to spinal cord infiltration of leukemia cells following the administration of intrathecal methotrexate and cytarabine. The paraplegia was initially reversible. However, a few weeks later, the patient developed irreversible paraplegia due to a complication of the intrathecal administration of chemotherapy (methotrexate and cytarabine arabinoside). The patient gave up further treatment in May 2013 and succumbed to the disease in June 2013.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Pan Y, Wang C, Wang H, Tao Q, Xiong S and Zhai Z: Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report. Oncol Lett 11: 4066-4068, 2016
APA
Pan, Y., Wang, C., Wang, H., Tao, Q., Xiong, S., & Zhai, Z. (2016). Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report. Oncology Letters, 11, 4066-4068. https://doi.org/10.3892/ol.2016.4519
MLA
Pan, Y., Wang, C., Wang, H., Tao, Q., Xiong, S., Zhai, Z."Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report". Oncology Letters 11.6 (2016): 4066-4068.
Chicago
Pan, Y., Wang, C., Wang, H., Tao, Q., Xiong, S., Zhai, Z."Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report". Oncology Letters 11, no. 6 (2016): 4066-4068. https://doi.org/10.3892/ol.2016.4519