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Article Open Access

Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines

Retraction in: /10.3892/ol.2024.14561
  • Authors:
    • Xiao‑Meng Chen
    • Meng Zhang
    • Peng‑Li Fan
    • Yu‑Hua Qin
    • Hong‑Wei Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3917-3924
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    Published online on: May 5, 2016
       https://doi.org/10.3892/ol.2016.4520
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Abstract

Previous studies have demonstrated that the benzo[c]phenanthridine alkaloid chelerythrine chloride (CC) has inhibitory effects on various tumors. However, the anticancer activity of CC and its underlying mechanisms have not been elucidated in renal cancer cells. The present study examined the effects of CC on growth inhibition and apoptosis of renal cancer cells in vitro and in vivo. Flow cytometry and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays revealed that CC markedly suppressed the growth of HEK‑293 and human renal cancer SW‑839 cells in a time- and dose‑dependent manner. The xenograft mouse model, which was performed in nude mice, exhibited a reduced tumor growth following CC treatment. In addition, the present study revealed that CC significantly decreased the phosphorylation of extracellular signal‑regulated kinase (ERK) and Akt, which was accompanied by upregulation of p53, B-cell lymphoma 2 (Bcl‑2)‑associated X protein, cleaved caspase‑3 and cleaved poly (adenosine diphosphate-ribose) polymerase (PARP), and downregulation of Bcl‑2, caspase‑3 and PARP. Furthermore, the use of PD98059, a specific mitogen‑activated protein kinase kinase inhibitor, potentiated the proapoptotic effects of CC, which indicated that CC may induce apoptosis in renal cancer cells partly via inhibition of ERK activity. Overall, the results of the present study demonstrated that CC may be developed as a potential anticancer treatment for patients with renal cancer.
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View References

1 

Novick AC: Kidney cancer: Past, present and future. Urol Oncol. 25:188–195. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Rini BI, Campbell SC and Escudier B: Renal cell carcinoma. Lancet. 373:1119–1132. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Costa LJ and Drabkin HA: Renal cell carcinoma: New developments in molecular biology and potential for targeted therapies. Oncologist. 12:1404–1415. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Janzen NK, Kim HL, Figlin RA and Belldegrun AS: Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol Clin North Am. 30:843–852. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Motzer RJ, Bander NH and Nanus DM: Renal-cell carcinoma. N Engl J Med. 335:865–875. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Ljungberg B, Cowan NC, Hanbury DC, Hora M, Kuczyk MA, Merseburger AS, Patard JJ, Mulders PF and Sinescu IC: European Association of Urology Guideline Group: EAU guidelines on renal cell carcinoma: The 2010 update. Eur Urol. 58:398–406. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Cohen HT and McGovern FJ: Renal-cell carcinoma. N Engl J Med. 353:2477–2490. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Hollingsworth JM, Miller DC, Daignault S and Hollenbeck BK: Five-year survival after surgical treatment for kidney cancer: A population-based competing risk analysis. Cancer. 109:1763–1768. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Flanigan RC, Salmon SE, Blumenstein BA, Bearman SI, Roy V, McGrath PC, Caton JR Jr, Munshi N and Crawford ED: Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med. 345:1655–1659. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Milella M and Felici A: Biology of metastatic renal cell carcinoma. J Cancer. 2:369–373. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Ramirez-Mares MV, Chandra S and de Mejia EG: In vitro chemopreventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols. Mutat Res. 554:53–65. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Chmura SJ, Dolan ME, Cha A, Mauceri HJ, Kufe DW and Weichselbaum RR: In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clin Cancer Res. 6:737–742. 2000.PubMed/NCBI

14 

Adhami VM, Aziz MH, Reagan-Shaw SR, Nihal M, Mukhtar H and Ahmad N: Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol Cancer Ther. 3:933–940. 2004.PubMed/NCBI

15 

Walterová D, Ulrichová J, Válka I, Vicar J, Vavrecková C, Táborská E, Harjrader RJ, Meyer DL, Cerná H and Simánek V: Benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine: Biological activities and dental care applications. Acta Univ Palacki Olomuc Fac Med. 139:7–16. 1995.PubMed/NCBI

16 

Zdařilováa A, Malíkováb J, Dvořáka Z, Ulrichováa J and Šimánek V: Quaternary isoquinoline alkaloids sanguinarine and chelerythrine in vitro and in vivo effects. Chem Listy. 100:30–41. 2006.

17 

Yang R, Piperdi S and Gorlick R: Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma. Clin Cancer Res. 14:6396–6404. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Kumar S, Tomar MS and Acharya A: Chelerythrine delayed tumor growth and increased survival duration of Dalton's lymphoma bearing BALB/c H (2d) mice by activation of NK cells in vivo. J Cancer Res Ther. 11:904–910. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Wan KF, Chan SL, Sukumaran SK, Lee MC and Yu VC: Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism. J Biol Chem. 283:8423–8433. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Chmura SJ, Nodzenski E, Crane MA, Virudachalam S, Hallahan DE, Weichselbaum RR and Quintans J: Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231. Adv Exp Med Biol. 406:39–55. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Freemerman AJ, Turner AJ, Birrer MJ, Szabo E, Valerie K and Grant S: Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C. Mol Pharmacol. 49:788–795. 1996.PubMed/NCBI

22 

Chan SL, Lee MC, Tan KO, Yang LK, Lee AS, Flotow H, Fu NY, Butler MS, Soejarto DD, Buss AD and Yu VC: Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem. 278:20453–20456. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Kemény-Beke A, Aradi J, Damjanovich J, Beck Z, Facskó A, Berta A and Bodnár A: Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Lett. 237:67–75. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Yamamoto S, Seta K, Morisco C, Vatner SF and Sadoshima J: Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes. J Mol Cell Cardiol. 33:1829–1848. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Herbert JM, Augereau JM, Gleye J and Maffrand JP: Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 172:993–999. 1990. View Article : Google Scholar : PubMed/NCBI

26 

Vogt A, Tamewitz A, Skoko J, Sikorski RP, Giuliano KA and Lazo JS: The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. J Biol Chem. 280:19078–19086. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Zdarilová A, Vrzal R, Rypka M, Ulrichová J and Dvorák Z: Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells. Food Chem Toxicol. 44:242–249. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Kemeny-Beke A, Aradi J, Damjanovich J, Beck Z, Facsko A, Berta A and Bodnar A: Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Lett. 237:67–75. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Ulrichová J, Dvorák Z, Vicar J, Lata J, Smrzová J, Sedo A and Simánek V: Cytotoxicity of natural compounds in hepatocyte cell culture models. The case of quaternary benzo[c]phenanthridine alkaloids. Toxicol Lett. 125:125–132. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Jarvis WD, Turner AJ, Povirk LF, Traylor RS and Grant S: Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res. 54:1707–1714. 1994.PubMed/NCBI

31 

Malíková J, Zdarilová A, Hlobilková A and Ulrichová J: The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine. Cell Biol Toxicol. 22:439–453. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Matkar SS, Wrischnik LA and Hellmann-Blumberg U: Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis. Arch Biochem Biophys. 477:43–52. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Xing Z, Zhou Z, Yu R, Li S, Li C, Nilsson S and Liu Z: XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells. J Exp Clin Cancer Res. 29:1622010. View Article : Google Scholar : PubMed/NCBI

34 

Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC and Kromer G: Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science. 281:2027–2031. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Chou YH, Ho YS, Wu CC, Chai CY, Chen SC, Lee CH, Tsai PS and Wu CH: Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation. Food Chem Toxicol. 45:1356–1367. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Lin MW, Lin AS, Wu DC, Wang SS, Chang FR, Wu YC and Huang YB: Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. Food Chem Toxicol. 50:4333–4339. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Carson DA and Ribeiro JM: Apoptosis and disease. Lancet. 341:1251–1254. 1993. View Article : Google Scholar : PubMed/NCBI

38 

Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science. 267:1456–1462. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Roberts PJ and Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26:3291–3310. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Somanath PR, Vijai J, Kichina JV, Byzova T and Kandel ES: The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt. Oncogene. 28:2365–2369. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Somanath PR, Kandel ES, Hay N and Byzova TV: Akt1 signaling regulates integrin activation, matrix recognition and fibronectin assembly. J Biol Chem. 282:22964–22976. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Yang JS, Lin CW, Hsieh YS, Cheng HL, Lue KH, Yang SF and Lu KH: Selaginella tamariscina (Beauv.) possesses antimetastatic effects on human osteosarcoma cells by decreasing MMP-2 and MMP-9 secretions via p38 and Akt signaling pathways. Food Chem Toxicol. 59:801–807. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Thompson N and Lyons J: Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr Opin Pharmacol. 5:350–356. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Balmanno K and Cook SJ: Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ. 16:368–377. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Yu R, Mandlekar S, Tan TH and Kong AN: Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J Biol Chem. 275:9612–9619. 2000. View Article : Google Scholar : PubMed/NCBI

46 

Li C, Chi S, He N, Zhang X, Guicherit O, Wagner R, Tyring S and Xie J: IFNalpha induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling. Oncogene. 23:1608–1617. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Shelton JG, Steelman LS, White ER and McCubrey JA: Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. Cell Cycle. 3:372–379. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Yu Q: Restoring p53-mediated apoptosis in cancer cells: New opportunities for cancer therapy. Drug Resist Updat. 9:19–25. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Zhang N, Wang X, Huo Q, Li X, Wang H, Schneider P, Hu G and Yang Q: The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer. J Biol Chem. 288:9396–9407. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Schafer ZT and Kornbluth S: The apoptosome: Physiological, developmental, and pathological modes of regulation. Dev Cell. 10:549–561. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen XM, Zhang M, Fan PL, Qin YH and Zhao HW: Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines Retraction in /10.3892/ol.2024.14561. Oncol Lett 11: 3917-3924, 2016.
APA
Chen, X., Zhang, M., Fan, P., Qin, Y., & Zhao, H. (2016). Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines Retraction in /10.3892/ol.2024.14561. Oncology Letters, 11, 3917-3924. https://doi.org/10.3892/ol.2016.4520
MLA
Chen, X., Zhang, M., Fan, P., Qin, Y., Zhao, H."Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines Retraction in /10.3892/ol.2024.14561". Oncology Letters 11.6 (2016): 3917-3924.
Chicago
Chen, X., Zhang, M., Fan, P., Qin, Y., Zhao, H."Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines Retraction in /10.3892/ol.2024.14561". Oncology Letters 11, no. 6 (2016): 3917-3924. https://doi.org/10.3892/ol.2016.4520
Copy and paste a formatted citation
x
Spandidos Publications style
Chen XM, Zhang M, Fan PL, Qin YH and Zhao HW: Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines Retraction in /10.3892/ol.2024.14561. Oncol Lett 11: 3917-3924, 2016.
APA
Chen, X., Zhang, M., Fan, P., Qin, Y., & Zhao, H. (2016). Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines Retraction in /10.3892/ol.2024.14561. Oncology Letters, 11, 3917-3924. https://doi.org/10.3892/ol.2016.4520
MLA
Chen, X., Zhang, M., Fan, P., Qin, Y., Zhao, H."Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines Retraction in /10.3892/ol.2024.14561". Oncology Letters 11.6 (2016): 3917-3924.
Chicago
Chen, X., Zhang, M., Fan, P., Qin, Y., Zhao, H."Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines Retraction in /10.3892/ol.2024.14561". Oncology Letters 11, no. 6 (2016): 3917-3924. https://doi.org/10.3892/ol.2016.4520
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