Open Access

Prognostic significance of Dicer expression in hepatocellular carcinoma

  • Authors:
    • Li Zhang
    • Cuiju Wang
    • Shufeng Liu
    • Yufei Zhao
    • Chao Liu
    • Zhanjun Guo
  • View Affiliations

  • Published online on: May 9, 2016     https://doi.org/10.3892/ol.2016.4547
  • Pages: 3961-3966
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dicer is a RNaseIII endonuclease of the microRNA processing pathway, which is implicated in carcinogenesis of various types of human cancer. The present study assessed the expression level of Dicer in hepatocellular carcinoma (HCC) tissue to evaluate its association with HCC tumorigenesis. A low expression of Dicer was significantly associated with a shorter postoperative survival time of patients with HCC, which was assessed using the log‑rank test with Kaplan‑Meier survival analysis. Multivariate analysis identified that Dicer expression was an independent predictor for HCC outcome (relative risk, 0.660; 95% confidence interval, 0.506‑0.861; P=0.002). A functional assay demonstrated that Dicer overexpression inhibited the proliferation and promoted the apoptosis of HCC cells. In addition, a Transwell assay revealed that Dicer markedly inhibited the migration and invasion of HCC cells. The present findings indicate that Dicer expression modified the outcomes of HCC patients by inhibiting proliferation, promoting apoptosis and inhibiting metastasis of HCC cells.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang L, Wang C, Liu S, Zhao Y, Liu C and Guo Z: Prognostic significance of Dicer expression in hepatocellular carcinoma. Oncol Lett 11: 3961-3966, 2016
APA
Zhang, L., Wang, C., Liu, S., Zhao, Y., Liu, C., & Guo, Z. (2016). Prognostic significance of Dicer expression in hepatocellular carcinoma. Oncology Letters, 11, 3961-3966. https://doi.org/10.3892/ol.2016.4547
MLA
Zhang, L., Wang, C., Liu, S., Zhao, Y., Liu, C., Guo, Z."Prognostic significance of Dicer expression in hepatocellular carcinoma". Oncology Letters 11.6 (2016): 3961-3966.
Chicago
Zhang, L., Wang, C., Liu, S., Zhao, Y., Liu, C., Guo, Z."Prognostic significance of Dicer expression in hepatocellular carcinoma". Oncology Letters 11, no. 6 (2016): 3961-3966. https://doi.org/10.3892/ol.2016.4547