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Article

Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma

  • Authors:
    • Urszula Sulkowska
    • Andrzej Wincewicz Febp
    • Stanislaw Sulkowski
  • View Affiliations / Copyright

    Affiliations: Department of General Pathomorphology, Medical University of Bialystok, Bialystok 15‑269, Poland, Department of Pathology, Faculty of Medicine and Health Sciences, Jan Kochanowski Memorial University, Kielce 25‑317, Poland
  • Pages: 4134-4138
    |
    Published online on: May 9, 2016
       https://doi.org/10.3892/ol.2016.4550
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Abstract

Signal transducer and activator of transcription‑3 (STAT3) drives endometrial carcinogenesis, while signaling via gap junctions gets weakened during cancer progression. Connexin 26 (Cx26), Cx43 and STAT3 were immunohistochemically evaluated in 78 endometrioid adenocarcinomas: Nuclear expression of STAT3 positively correlated with cytoplasmic immunoreactivity to Cx43 (P=0.004, r=0.318) and Cx26 (P=0.006, r=0.309). STAT3 correlated with Cx43 (P=0.022, r=0.411) and Cx26 (P=0.008 r=0.466) in G1 tumors. A statistically significant linkage remained in G2 cancers between STAT3 and Cx43 (P=0.061, r=0.262) and Cx26 (P=0.016, r=0.331); however, no correlations were observed in G3 tumors. STAT3 was significantly associated with Cx 43 (p=0.003, r=0.684) and Cx26 (p=0.049, r=0.500) in estrogen receptor (ER) negative adenocarcinomas. STAT3 did not correlate with Cx43 in ER positive adenocarcinomas; however, STAT3 expression remained correlated with Cx26 expression (P=0.035, r=0.268). In progesterone receptor negative tumors STAT3 was significantly associated with Cx43 (P=0.035, r=0.451) and Cx26 (P<0.0001, r=0.707). However, in PgR positive adenocarcinomas STAT3 correlated with Cx43 (P=0.03, r=0.290) but not with Cx26. Thus, it appears that hormone dependent acceleration of cancer growth breaks the association between STAT3 and Cx expression. These associations become weaker as the tumors dedifferentiate from G1 to G3 endometrioid adenocarcinomas. The present study provides evidence that the loss of correlation between STAT3 and selected Cx proteins occurs in tumors with more aggressive behavior.
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Copy and paste a formatted citation
Spandidos Publications style
Sulkowska U, Febp AW and Sulkowski S: Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma. Oncol Lett 11: 4134-4138, 2016.
APA
Sulkowska, U., Febp, A.W., & Sulkowski, S. (2016). Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma. Oncology Letters, 11, 4134-4138. https://doi.org/10.3892/ol.2016.4550
MLA
Sulkowska, U., Febp, A. W., Sulkowski, S."Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma". Oncology Letters 11.6 (2016): 4134-4138.
Chicago
Sulkowska, U., Febp, A. W., Sulkowski, S."Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma". Oncology Letters 11, no. 6 (2016): 4134-4138. https://doi.org/10.3892/ol.2016.4550
Copy and paste a formatted citation
x
Spandidos Publications style
Sulkowska U, Febp AW and Sulkowski S: Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma. Oncol Lett 11: 4134-4138, 2016.
APA
Sulkowska, U., Febp, A.W., & Sulkowski, S. (2016). Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma. Oncology Letters, 11, 4134-4138. https://doi.org/10.3892/ol.2016.4550
MLA
Sulkowska, U., Febp, A. W., Sulkowski, S."Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma". Oncology Letters 11.6 (2016): 4134-4138.
Chicago
Sulkowska, U., Febp, A. W., Sulkowski, S."Association of STAT3 with Cx26 and Cx43 in human uterine endometrioid adenocarcinoma". Oncology Letters 11, no. 6 (2016): 4134-4138. https://doi.org/10.3892/ol.2016.4550
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