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Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study

  • Authors:
    • Youhong Dong
    • Anping Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China, Department of Neurology, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 89-92
    |
    Published online on: May 13, 2016
       https://doi.org/10.3892/ol.2016.4566
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Abstract

The aim of the retrospective study was to analyze the effect of pioglitazone on the expression of tumor tissue inflammation factor interleukin (IL)-8, macrophage colony-stimulating factor (M-CSF) and vascular endothelial growth factor (VEGF) of type II diabetes in bladder cancer patients. In addition, whether there was a correlation between pioglitazone and the occurrence of male bladder cancer was also investigated. In total, 42 male cases diagnosed with type II diabetes secondary to bladder cancer were selected. Forty male cases, with simplex type II diabetes but not with bladder cancer, served as the control. Tumor biopsy specimens were collected to detect the expression levels of IL-8, M-CSF and VEGF. The results showed that the expression of IL-8, M-CSF and VEGF of the simplex diabetes group was significantly lower than that of the secondary to tumor group (P<0.05). The comparison of the two groups in terms of daily dose and time of oral pioglitazone, duration of diabetes, average fasting blood sugar and glycated hemoglobin levels, was not statistically significant. Multivariable logistic regression analysis revealed that the expression levels of IL-8, M-CSF and VEGF were independent risk factors for the occurrence of bladder cancer (P<0.05), but were not associated with daily dose and time of oral pioglitazone (P>0.05). In conclusion, oral pioglitazone may not increase the risk of type II diabetes patients with bladder cancer. However, the occurrence of bladder cancer be associated with the increasing expression levels of IL-8, M-CSF and VEGF.
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1 

Shulman AI and Mangelsdorf DJ: Retinoid × receptor heterodimers in the metabolic syndrome. N Engl J Med. 353:604–615. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Tseng CH and Tseng FH: Peroxisome proliferator-activated receptor agonists and bladder cancer: lessons from animal studies. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 30:368–402. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Kostapanos MS, Elisaf MS and Mikhailidis DP: Pioglitazone and cancer: angel or demon? Curr Pharm Des. 19:4913–4929. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Grygiel-Górniak B: Peroxisome proliferator-activated receptors and their ligands: Nutritional and clinical implications - a review. Nutr J. 13:172014. View Article : Google Scholar : PubMed/NCBI

5 

Zhu YM and Woll PJ: Mitogenic effects of interleukin-8/CXCL8 on cancer cells. Future Oncol. 1:699–704. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Cui R, Qi Z, Zhou L, Li Z, Li Q and Zhang J: Evaluation of serum lipid profile, body mass index, and waistline in Chinese patients with type 2 diabetes mellitus. Clin Interv Aging. 11:445–452. 2016.PubMed/NCBI

7 

Lewis JD, Ferrara A, Peng T, Hedderson M, Bilker WB, Quesenberry CP Jr, Vaughn DJ, Nessel L, Selby J and Strom BL: Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study. Diabetes Care. 34:916–922. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Hsiao FY, Hsieh PH, Huang WF, Tsai YW and Gau CS: Risk of bladder cancer in diabetic patients treated with rosiglitazone or pioglitazone: a nested case - control study. Drug Saf. 36:643–649. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Song SO, Kim KJ, Lee BW, Kang ES, Cha BS and Lee HC: The risk of bladder cancer in korean diabetic subjects treated with pioglitazone. Diabetes Metab J. 36:371–378. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Geisinger ML, Michalowicz BS, Hou W, Schoenfeld E, Gelato M, Engebretson SP, Reddy MS and Hyman L: Systemic inflammatory biomarkers and their association with periodontal and diabetes-related factors in the diabetes and periodontal therapy trial (DPTT), a randomized controlled trial. J Periodontol. April 25–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

11 

Liu X, Peng J, Sun W, Yang S, Deng G, Li F, Cheng JW and Gordon JR: G31P, an antagonist against CXC chemokine receptors 1 and 2, inhibits growth of human prostate cancer cells in nude mice. Tohoku J Exp Med. 228:147–156. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Deng F, Wang J, Fan M, Guo Y, Li Y and Shi Q: [Overexpression of IL-8 promotes migration of BT549 breast cancer cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 32:585–589. 2016.PubMed/NCBI

13 

Lackner C, Jukic Z, Tsybrovskyy O, Jatzko G, Wette V, Hoefler G, Klimpfinger M, Denk H and Zatloukal K: Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancer. Virchows Arch. 445:160–167. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Infanger M, Kossmehl P, Shakibaei M, Cogoli A, Witzing A, Faramarzi S, Wittfoht W, Paul M and Grimm D: Vascular endothelial growth factor inhibits programmed cell death of endothelial cells induced by clinorotation. J Gravit Physiol. 11:199–200. 2004.

15 

Chodorowska G, Chodorowski J and Wysokiński A: Vascular endothelial growth factor (VEGF) in physiological and pathological conditions. Ann Univ Mariae Curie Sklodowska Med. 59:8–14. 2004.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong Y and Wang A: Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study. Oncol Lett 12: 89-92, 2016.
APA
Dong, Y., & Wang, A. (2016). Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study. Oncology Letters, 12, 89-92. https://doi.org/10.3892/ol.2016.4566
MLA
Dong, Y., Wang, A."Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study". Oncology Letters 12.1 (2016): 89-92.
Chicago
Dong, Y., Wang, A."Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study". Oncology Letters 12, no. 1 (2016): 89-92. https://doi.org/10.3892/ol.2016.4566
Copy and paste a formatted citation
x
Spandidos Publications style
Dong Y and Wang A: Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study. Oncol Lett 12: 89-92, 2016.
APA
Dong, Y., & Wang, A. (2016). Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study. Oncology Letters, 12, 89-92. https://doi.org/10.3892/ol.2016.4566
MLA
Dong, Y., Wang, A."Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study". Oncology Letters 12.1 (2016): 89-92.
Chicago
Dong, Y., Wang, A."Pioglitazone does not increase the risk of type II diabetes in patients with bladder cancer: A retrospective study". Oncology Letters 12, no. 1 (2016): 89-92. https://doi.org/10.3892/ol.2016.4566
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