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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation

  • Authors:
    • Hyun Joo Jang
    • Eun Mi Hong
    • Se Woo Park
    • Hyun Woo Byun
    • Dong Hee Koh
    • Min Ho Choi
    • Sea Hyub Kae
    • Jin Lee
  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University School of Medicine, Hwasung, Gyeonggi 445‑170, Republic of Korea
  • Pages: 250-256
    |
    Published online on: May 13, 2016
       https://doi.org/10.3892/ol.2016.4569
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Abstract

Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) signaling plays an important role in tumor progression in patients with certain gastrointestinal tract cancers. In addition to lowering cholesterol in serum, statins have pleiotropic effects, including anti-oxidative, anti‑inflammatory or anti‑neoplastic effects. Therefore, the present study investigated whether statins could induce the apoptosis of colon cancer cells and regulate the expression of IGF‑1R and its associated signaling pathways in the present study. It was demonstrated that simvastatin and pravastatin suppressed cell proliferation and induced cell death in human HT‑29 cells, but simvastatin was more potent than pravastatin. Simvastatin induced apoptosis in a concentration‑dependent manner. In addition, simvastatin suppressed the expression of IGF‑1R and inhibited the activity of phosphorylated‑extracellular signal‑regulated kinase (ERK)1/2 and phosphorylated‑Akt activated by IGF‑1. Simvastatin and IGF‑1 each stimulated the activity of phosphorylated ERK1/2. However, simvastatin inhibited cell proliferation and IGF‑1 stimulated cell proliferation. Mevalonic acid and PD98059 reversed the ERK activation and apoptosis induced by treatment with simvastatin. It was concluded that simvastatin induces the apoptosis of human colon cancer cells and inhibits IGF‑1‑induced ERK and Akt expression via the downregulation of IGF‑1R expression and proapoptotic ERK activation. Simvastatin may be beneficial for the treatment of colon cancer. The present study suggested that statin may possess therapeutic potential for the treatment of colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Jang HJ, Hong EM, Park SW, Byun HW, Koh DH, Choi MH, Kae SH and Lee J: Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. Oncol Lett 12: 250-256, 2016.
APA
Jang, H.J., Hong, E.M., Park, S.W., Byun, H.W., Koh, D.H., Choi, M.H. ... Lee, J. (2016). Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. Oncology Letters, 12, 250-256. https://doi.org/10.3892/ol.2016.4569
MLA
Jang, H. J., Hong, E. M., Park, S. W., Byun, H. W., Koh, D. H., Choi, M. H., Kae, S. H., Lee, J."Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation". Oncology Letters 12.1 (2016): 250-256.
Chicago
Jang, H. J., Hong, E. M., Park, S. W., Byun, H. W., Koh, D. H., Choi, M. H., Kae, S. H., Lee, J."Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation". Oncology Letters 12, no. 1 (2016): 250-256. https://doi.org/10.3892/ol.2016.4569
Copy and paste a formatted citation
x
Spandidos Publications style
Jang HJ, Hong EM, Park SW, Byun HW, Koh DH, Choi MH, Kae SH and Lee J: Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. Oncol Lett 12: 250-256, 2016.
APA
Jang, H.J., Hong, E.M., Park, S.W., Byun, H.W., Koh, D.H., Choi, M.H. ... Lee, J. (2016). Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. Oncology Letters, 12, 250-256. https://doi.org/10.3892/ol.2016.4569
MLA
Jang, H. J., Hong, E. M., Park, S. W., Byun, H. W., Koh, D. H., Choi, M. H., Kae, S. H., Lee, J."Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation". Oncology Letters 12.1 (2016): 250-256.
Chicago
Jang, H. J., Hong, E. M., Park, S. W., Byun, H. W., Koh, D. H., Choi, M. H., Kae, S. H., Lee, J."Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation". Oncology Letters 12, no. 1 (2016): 250-256. https://doi.org/10.3892/ol.2016.4569
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