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Article

miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2

Retraction in: /10.3892/ol.2021.12873
  • Authors:
    • Xingyu Lin
    • Zhiguang Yang
    • Peng Zhang
    • Yunpeng Liu
    • Guoguang Shao
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 301-306
    |
    Published online on: May 16, 2016
       https://doi.org/10.3892/ol.2016.4577
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Abstract

Emerging evidence suggests that microRNAs (miRs) play critical roles in the development and progression of non-small cell lung cancer (NSCLC). In a previous study, the present authors demonstrated that miR-154 acts as a tumor suppressor in NSCLC; however, its underlying molecular mechanism and target in NSCLC remain poorly understood. In the present study, ectopic expression of miR‑154 remarkably suppressed cell migration and invasion in NSCLC cells. Zinc finger E‑box binding homeobox 2 (ZEB2) was identified as a direct target of miR‑154 in NSCLC cells. Furthermore, overexpression of miR‑154 could decrease the expression of ZEB2 at the messenger RNA and protein levels. Ectopic expression of miR‑154 also increased the levels of E‑cadherin, an epithelial marker, and decreased the levels of vimentin, a mesenchymal marker, which contributed to suppress epithelial‑mesenchymal transition (EMT) and to inhibit cell migration and invasion. In addition, downregulation of ZEB2 exerted similar effects to those caused by miR‑154 overexpression on NSCLC cell migration and invasion, while upregulation of ZEB2 could significantly reverse the inhibitory effects on migration and invasion caused by miR‑154 on NSCLC cells. These findings demonstrated that miR‑154 inhibited migration and invasion of NSCLC cells by regulating EMT through targeting ZEB2, suggesting that miR‑154 may be a potential anticancer therapeutic target for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Lin X, Yang Z, Zhang P, Liu Y and Shao G: miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2 Retraction in /10.3892/ol.2021.12873. Oncol Lett 12: 301-306, 2016.
APA
Lin, X., Yang, Z., Zhang, P., Liu, Y., & Shao, G. (2016). miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2 Retraction in /10.3892/ol.2021.12873. Oncology Letters, 12, 301-306. https://doi.org/10.3892/ol.2016.4577
MLA
Lin, X., Yang, Z., Zhang, P., Liu, Y., Shao, G."miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2 Retraction in /10.3892/ol.2021.12873". Oncology Letters 12.1 (2016): 301-306.
Chicago
Lin, X., Yang, Z., Zhang, P., Liu, Y., Shao, G."miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2 Retraction in /10.3892/ol.2021.12873". Oncology Letters 12, no. 1 (2016): 301-306. https://doi.org/10.3892/ol.2016.4577
Copy and paste a formatted citation
x
Spandidos Publications style
Lin X, Yang Z, Zhang P, Liu Y and Shao G: miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2 Retraction in /10.3892/ol.2021.12873. Oncol Lett 12: 301-306, 2016.
APA
Lin, X., Yang, Z., Zhang, P., Liu, Y., & Shao, G. (2016). miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2 Retraction in /10.3892/ol.2021.12873. Oncology Letters, 12, 301-306. https://doi.org/10.3892/ol.2016.4577
MLA
Lin, X., Yang, Z., Zhang, P., Liu, Y., Shao, G."miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2 Retraction in /10.3892/ol.2021.12873". Oncology Letters 12.1 (2016): 301-306.
Chicago
Lin, X., Yang, Z., Zhang, P., Liu, Y., Shao, G."miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2 Retraction in /10.3892/ol.2021.12873". Oncology Letters 12, no. 1 (2016): 301-306. https://doi.org/10.3892/ol.2016.4577
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