Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2016 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2016 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model

  • Authors:
    • Robson Q. Monteiro
    • Luize G. Lima
    • Nathália P. Gonçalves
    • Mayara R. Arruda De Souza
    • Ana C. Leal
    • Marcos A. Almeida Demasi
    • Mari C. Sogayar
    • Tatiana C. Carneiro‑Lobo
  • View Affiliations / Copyright

    Affiliations: Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941‑902, Brazil, Cell and Molecular Therapy Center (NUCEL‑NETCEM), Internal Medicine Department, School of Medicine, University of São Paulo, São Paulo, SP 05360‑120, Brazil
  • Pages: 315-322
    |
    Published online on: May 17, 2016
       https://doi.org/10.3892/ol.2016.4593
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hypoxia and necrosis are fundamental features of glioma, and their emergence is critical for the rapid biological progression of this fatal tumor. The presence of vaso‑occlusive thrombus is higher in grade IV tumors [glioblastoma multiforme (GBM)] compared with lower grade tumors, suggesting that the procoagulant properties of the tumor contribute to its aggressive behavior, as well as the establishment of tumor hypoxia and necrosis. Tissue factor (TF), the primary cellular initiator of coagulation, is overexpressed in GBMs and likely favors a thrombotic microenvironment. Phosphatase and tensin homolog (PTEN) loss and hypoxia are two common alterations observed in glioma that may be responsible for TF upregulation. In the present study, ST1 and P7 rat glioma lines, with different levels of aggressiveness, were comparatively analyzed with the aim of identifying differences in procoagulant mechanisms. The results indicated that P7 cells display potent procoagulant activity compared with ST1 cells. Flow cytometric analysis showed less pronounced levels of TF in ST1 cells compared with P7 cells. Notably, P7 cells supported factor X (FX) activation via factor VIIa, whereas no significant FXa generation was observed in ST1 cells. Furthermore, the exposure of phosphatidylserine on the surface of P7 and ST1 cells was investigated. The results supported the assembly of prothrombinase complexes, accounting for the production of thrombin. Furthermore, reverse transcription‑quantitative polymerase chain reaction showed that CoCl2 (known to induce a hypoxic‑like stress) led to an upregulation of TF levels in P7 and ST1 cells. Therefore, increased TF expression in P7 cells was accompanied by increased TF procoagulant activity. In addition, hypoxia increased the shedding of procoagulant TF‑bearing microvesicles in both cell lines. Finally, hypoxic stress induced by treatment with CoCl2 upregulated the expression of the PAR1 receptor in both P7 and ST1 cells. In addition to PAR1, P7, but not ST1 cells, expressed higher levels of PAR2 under hypoxic stress. Thus, modulating these molecular interactions may provide additional insights for the development of more efficient therapeutic strategies against aggressive glioma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Williams JC and Mackman N: Tissue factor in health and disease. Front Biosci. 1:358–372. 2012. View Article : Google Scholar

2 

Østerud B and Bjørklid E: Sources of tissue factor. Semin Thromb Hemost. 32:11–23. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Francischetti IM, Seydel KB and Monteiro RQ: Blood coagulation, inflammation, and malaria. Microcirculation. 15:81–107. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Brat DJ and Van Meir EG: Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma. Lab Invest. 84:397–405. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Rak J, Milsom C, Magnus N and Yu J: Tissue factor in tumour progression. Best Pract Res Clin Haematol. 22:71–83. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Kasthuri RS, Taubman MB and Mackman N: Role of tissue factor in cancer. J Clin Oncol. 27:4834–4838. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Ruf W, Disse J, Carneiro-Lobo TC, Yokota N and Schaffner F: Tissue factor and cell signalling in cancer progression and thrombosis. J Thromb Haemost. 9(Suppl 1): S306–S315. 2011. View Article : Google Scholar

8 

van den Berg YW, Osanto S, Reitsma PH and Versteeg HH: The relationship between tissue factor and cancer progression: Insights from bench and bedside. Blood. 119:924–932. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Lima LG and Monteiro RQ: Activation of blood coagulation in cancer: Implications for tumour progression. Biosci Rep. 33:e000642013. View Article : Google Scholar : PubMed/NCBI

10 

Lima LG, Oliveira AS, Campos LC, Bonamino M, Chammas R, Werneck C, Vicente CP, Barcinski MA, Petersen LC and Monteiro RQ: Malignant transformation in melanocytes is associated with increased production of procoagulant microvesicles. Thromb Haemost. 106:712–723. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Zhou L, Qi XL, Xu MX, Mao Y, Liu ML and Song HM: Microparticles: New light shed on the understanding of venous thromboembolism. Acta Pharmacol Sin. 35:1103–1110. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Boire A, Covic L, Agarwal A, Jacques S, Sherifi S and Kuliopulos A: PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell. 120:303–313. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Albrektsen T, Sørensen BB, Hjortø GM, Fleckner J, Rao LV and Petersen LC: Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells. J Thromb Haemost. 5:1588–1597. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Wen PY and Kerasi S: Malignant gliomas in adults. N Engl J Med. 359:492–507. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Evans SM, Judy KD, Dunphy I, Jenkins WT, Nelson PT, Lustig RA, Jenkins K, Magarelli DP, Hahn SM, Collins RA, et al: Hypoxia is important in the biology and aggression of human glial brain tumors. Clin Cancer Res. 10:8177–8184. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Brown JM and Wilson WR: Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer. 4:437–447. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Anand M and Brat DJ: Oncogenic regulation of tissue factor and thrombosis in cancer. Thromb Res. 129(Suppl 1): S46–S49. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Magnus N, D'Asti E, Meehan B, Garnier D and Rak J: Oncogenes and the coagulation system-forces that modulate dormant and aggressive states in cancer. Thromb Res. 133(Suppl 2): S1–S9. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Rong Y, Post DE, Pieper RO, Durden DL, Van Meir EG and Brat DJ: PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma. Cancer Res. 65:1406–1413. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Magnus N, Garnier D and Rak J: Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells. Blood. 116:815–818. 2010. View Article : Google Scholar : PubMed/NCBI

21 

D'Asti E, Fang Y and Rak J: Brain neoplasms and coagulation-lessons from heterogeneity. Rambam Maimonides Med J. 5:e00302014. View Article : Google Scholar : PubMed/NCBI

22 

Carneiro-Lobo TC, Lima MT, Mariano-Oliveira A, Dutra-Oliveira A, Oba-Shinjo SM, Marie SK, Sogayar MC and Monteiro RQ: Expression of tissue factor signaling pathway elements correlates with the production of vascular endothelial growyh factor and interleukin-8 in human astrocytoma patients. Oncol Rep. 31:679–686. 2014.PubMed/NCBI

23 

Armelin MC and Armelin HÀ: Glucocorticoid hormone modulation of both cell surface and cytoskeleton related to growth control of rat glioma cells. J Cell Biol. 97:459–465. 1983. View Article : Google Scholar : PubMed/NCBI

24 

Armelin MC, Stocco RC and Armelin HA: Control of rat C6 glioma cell proliferation: Uncoupling of the inhibitory effects of hydrocortisone hormone in suspension and monolayer cultures. J Cell Biol. 97:455–458. 1983. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Hamada K, Kuratsu J, Saitoh Y, Takeshima H, Nishi T and Ushio Y: Expression of tissue factor correlates with grade of malignancy in human glioma. Cancer. 77:1877–1883. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Guan M, Jin J, Su B, Liu WW and Lu Y: Tissue factor expression and angiogenesis in human glioma. Clin Biochem. 35:321–325. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Fernandes RS, Kirszberg C, Rumjanek VM and Monteiro RQ: On the molecular mechanisms for the highly procoagulant pattern of C6 glioma cells. J Thromb Haemost. 4:1546–1552. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Kirszberg C, Lima LG, Da Silva de Oliveira A, Pickering W, Gray E, Barrowcliffe TW, Rumjanek VM and Monteiro RQ: Simultaneous tissue factor expression and phosphatidylserine exposure account for the highly procoagulant pattern of melanoma cell lines. Melanoma Res. 19:301–308. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Brat DJ, Castellano-Sanchez AA, Hunter SB, Pecot M, Cohen C, Hammond EH, Devi SN, Kaur B and Van Meir EG: Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases and are formed by an actively migrating cell population. Cancer Res. 64:920–927. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Rautou PE and Mackman N: Microvesicles as risk markers for venous thrombosis. Expert Rev Hematol. 6:91–101. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Svensson KJ, Kucharzewska P, Christianson HC, Sköld S, Löfstedt T, Johansson MC, Mörgelin M, Bengzon J, Ruf W and Belting M: Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc Natl Acad Sci USA. 108:13147–13152. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Naldini A, Filippi I, Ardinghi C, Silini A, Giavazzi R and Carraro F: Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells. Eur J Cancer. 45:454–460. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Hammoud MA, Sawaya R, Shi W, Thall PF and Leeds NE: Prognostic significance of preoperative MRI scans in glioblastoma multiforme. J Neurooncol. 27:65–73. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Tehrani M, Friedman TM, Olson JJ and Brat DJ: Intravascular thrombosis in central nervous system malignancies: A potential role in astrocytoma progression to glioblastoma. Brain Pathol. 18:164–171. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Blanco VM, Chu Z, Vallabhapurapu SD, Sulaiman MK, Kendler A, Rixe O, Warnick RE, Franco RS and Qi X: Phosphatidylserine-selective targeting and anticancer effects of SapC-DOPS nanovesicles on brain tumors. Oncotarget. 5:7105–7118. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Wang T, Gilkes DM, Takano N, Xiang L, Luo W, Bishop CJ, Chaturvedi P, Green JJ and Semenza GL: Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci USA. 111:E3234–E3242. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Marras LC, Geerts WH and Perry JR: The risk of venous thromboembolism is increased throughout the course of malignant glioma: An evidence-based review. Cancer. 89:640–664. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Thaler J, Ay C, Mackman N, Bertina RM, Kaider A, Marosi C, Key NS, Barcel DA, Scheithauer W, Kornek G, et al: Microparticle-associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients. J Thromb Haemost. 10:1363–1370. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Thaler J, Preusser M, Ay C, Kaider A, Marosi C, Zielinski C, Pabinger I and Hainfellner JA: Intratumoral tissue factor expression and risk of venous thromboembolism in brain tumor patients. Thromb Res. 131:162–165. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Lima LG, Leal AC, Vargas G, Porto-Carreiro I and Monteiro RQ: Intercellular transfer of tissue factor via the uptake of tumor-derived microvesicles. Thromb Res. 132:450–456. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Zhang Y, Zhan H, Xu W, Yuan Z, Lu P, Zhan L and Li Q: Upregulation of matrix metalloproteinase-1 and proteinase-activated receptor-1 promotes the progression of human gliomas. Pathol Res Pract. 207:24–29. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Itsekson-Hayosh Z, Shavit-Stein E, Last D, Goez D, Daniels D, Bushi D, Gera O, Zibly Z, Mardor Y, Chapman J and Harnof S: Thrombin activity and thrombin receptor in rat glioblastoma model: Possible markers and targets for intervention? J Mol Neurosci. 56:644–651. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Dutra-Oliveira A, Monteiro RQ and Mariano-Oliveira A: Protease-activated receptor-2 (PAR2) mediates VEGF production through the ERK1/2 pathway in human glioblastoma cell lines. Biochem Biophys Res Commun. 421:221–227. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Harter PN, Dützmann S, Drott U, Zachskorn C, Hattingen E, Capper D, Gessler F, Senft C, Seifert V, Plate KH, et al: Anti-tissue factor (TF9-10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model. Neuropathology. 33:515–525. 2013.PubMed/NCBI

46 

Luo R, Wang X, Dong Y, Wang L and Tian C: Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis. J Biomed Sci. 21:252014. View Article : Google Scholar : PubMed/NCBI

47 

Carneiro-Lobo TC, Konig S, Machado DE, Nasciutti LE, Forni MF, Francischetti IM, Sogayar MC and Monteiro RQ: Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model. J Thromb Haemost. 7:1855–1864. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Carneiro-Lobo TC, Schaffner F, Disse J, Ostergaard H, Francischetti IM, Monteiro RQ and Ruf W: The tick-derived inhibitor Ixolaris prevents tissue factor signaling on tumor cells. J Thromb Haemost. 10:1849–1858. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Monteiro RQ, Lima LG, Gonçalves NP, De Souza MR, Leal AC, Demasi MA, Sogayar MC and Carneiro‑Lobo TC: Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model. Oncol Lett 12: 315-322, 2016.
APA
Monteiro, R.Q., Lima, L.G., Gonçalves, N.P., De Souza, M.R., Leal, A.C., Demasi, M.A. ... Carneiro‑Lobo, T.C. (2016). Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model. Oncology Letters, 12, 315-322. https://doi.org/10.3892/ol.2016.4593
MLA
Monteiro, R. Q., Lima, L. G., Gonçalves, N. P., De Souza, M. R., Leal, A. C., Demasi, M. A., Sogayar, M. C., Carneiro‑Lobo, T. C."Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model". Oncology Letters 12.1 (2016): 315-322.
Chicago
Monteiro, R. Q., Lima, L. G., Gonçalves, N. P., De Souza, M. R., Leal, A. C., Demasi, M. A., Sogayar, M. C., Carneiro‑Lobo, T. C."Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model". Oncology Letters 12, no. 1 (2016): 315-322. https://doi.org/10.3892/ol.2016.4593
Copy and paste a formatted citation
x
Spandidos Publications style
Monteiro RQ, Lima LG, Gonçalves NP, De Souza MR, Leal AC, Demasi MA, Sogayar MC and Carneiro‑Lobo TC: Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model. Oncol Lett 12: 315-322, 2016.
APA
Monteiro, R.Q., Lima, L.G., Gonçalves, N.P., De Souza, M.R., Leal, A.C., Demasi, M.A. ... Carneiro‑Lobo, T.C. (2016). Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model. Oncology Letters, 12, 315-322. https://doi.org/10.3892/ol.2016.4593
MLA
Monteiro, R. Q., Lima, L. G., Gonçalves, N. P., De Souza, M. R., Leal, A. C., Demasi, M. A., Sogayar, M. C., Carneiro‑Lobo, T. C."Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model". Oncology Letters 12.1 (2016): 315-322.
Chicago
Monteiro, R. Q., Lima, L. G., Gonçalves, N. P., De Souza, M. R., Leal, A. C., Demasi, M. A., Sogayar, M. C., Carneiro‑Lobo, T. C."Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model". Oncology Letters 12, no. 1 (2016): 315-322. https://doi.org/10.3892/ol.2016.4593
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team