miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma

Wang,Shaohua; Cao,Ke; He,Quanyong; Yin,Zhaoqi; Zhou,Jianda

doi:10.3892/ol.2016.4602

miR-199a-5p induces cell invasion by suppressing E-cadherin expression in cutaneous squamous cell carcinoma

Authors:
- Shaohua Wang
- Ke Cao
- Quanyong He
- Zhaoqi Yin
- Jianda Zhou
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Affiliations: Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Oncology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China
Published online on: May 18, 2016 https://doi.org/10.3892/ol.2016.4602
Pages: 97-101
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

A growing quantity of evidence exists to suggest that microRNAs are significant regulators of multiple cellular processes. When expressed aberrantly in different types of cancer, including cutaneous squamous cell carcinoma (cSCC), they play key roles in tumorigenesis and progression. The aberrant expression of miR‑199a‑5p has been observed to contribute to carcinogenesis in various types of cancer. However, the role of miR‑199a‑5p in the progression of cSCC metastasis remains largely unknown. In this study, we determined that miR‑199a‑5p was the upstream regulator of CDH1 (E‑cadherin) and that it could suppress the expression of E‑cadherin in cSCC cells. In addition, miR‑199a‑5p mimics significantly induced cell invasion and the activity of matrix metalloproteinase (MMP)2 and MMP9 in cSCC cells. In conclusion, these results are likely to aid in elucidating the molecular mechanisms of cSCC progression. In addition, the findings provide a new theoretical basis to further investigate miR‑199a‑5p as a potential biomarker and a promising approach in cSCC treatment.

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