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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia

  • Authors:
    • Shun‑Quan Wu
    • Lang‑Hui Zhang
    • Hao‑Bo Huang
    • Ya‑Ping Li
    • Wen‑Yan Niu
    • Rong Zhan
  • View Affiliations / Copyright

    Affiliations: Fujian Institute of Hematology, Affiliated Union Hospital of Fujian Medical University, Fujian Provincial Key Laboratory on Hematology, Fuzhou, Fujian 350001, P.R. China
  • Pages: 741-747
    |
    Published online on: May 25, 2016
       https://doi.org/10.3892/ol.2016.4621
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Abstract

MicroRNAs (miRs) are often located in genomic breakpoint regions and are hypothesized to be important regulators involved in the regulation of critical cell processes, including cell apoptosis, proliferation and differentiation. miR-299 has been reported to be upregulated in acute promyelocytic leukemia (APL); however, the function and mechanistic role of miR-299 in APL remains unknown. The present study demonstrated mir‑299 significantly induced cell growth and cell cycle progression at the G1/S transition in APL cells. Notably, the present study revealed that miR‑299‑5p induces these effects, whereas miR‑299‑3p does not. Additional studies demonstrated that in APL cells the tumor suppressor p21Cip1/Waf1 is a downstream target of miR-299; miR‑299 binds directly to the 3' untranslated region of p21Cip1/Waf1, and reduces protein, but not mRNA, levels of p21Cip1/Waf1. The present findings demonstrate that miR‑299 exerts growth‑promoting effects in APL cells through the suppression of p21Cip1/Waf1. Overall, the present study demonstrates that p21Cip1/Waf1 is a direct functional target of miR‑299 in APL.
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Copy and paste a formatted citation
Spandidos Publications style
Wu SQ, Zhang LH, Huang HB, Li YP, Niu WY and Zhan R: miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia. Oncol Lett 12: 741-747, 2016.
APA
Wu, S., Zhang, L., Huang, H., Li, Y., Niu, W., & Zhan, R. (2016). miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia. Oncology Letters, 12, 741-747. https://doi.org/10.3892/ol.2016.4621
MLA
Wu, S., Zhang, L., Huang, H., Li, Y., Niu, W., Zhan, R."miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia". Oncology Letters 12.1 (2016): 741-747.
Chicago
Wu, S., Zhang, L., Huang, H., Li, Y., Niu, W., Zhan, R."miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia". Oncology Letters 12, no. 1 (2016): 741-747. https://doi.org/10.3892/ol.2016.4621
Copy and paste a formatted citation
x
Spandidos Publications style
Wu SQ, Zhang LH, Huang HB, Li YP, Niu WY and Zhan R: miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia. Oncol Lett 12: 741-747, 2016.
APA
Wu, S., Zhang, L., Huang, H., Li, Y., Niu, W., & Zhan, R. (2016). miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia. Oncology Letters, 12, 741-747. https://doi.org/10.3892/ol.2016.4621
MLA
Wu, S., Zhang, L., Huang, H., Li, Y., Niu, W., Zhan, R."miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia". Oncology Letters 12.1 (2016): 741-747.
Chicago
Wu, S., Zhang, L., Huang, H., Li, Y., Niu, W., Zhan, R."miR-299-5p promotes cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in acute promyelocytic leukemia". Oncology Letters 12, no. 1 (2016): 741-747. https://doi.org/10.3892/ol.2016.4621
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