Open Access

Interleukin-33 in human gliomas: Expression and prognostic significance

  • Authors:
    • Dorothee Gramatzki
    • Karl Frei
    • Gieri Cathomas
    • Holger Moch
    • Michael Weller
    • Kirsten Diana Mertz
  • View Affiliations

  • Published online on: May 25, 2016     https://doi.org/10.3892/ol.2016.4626
  • Pages: 445-452
  • Copyright: © Gramatzki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Interleukin-33 (IL-33) is a nuclear and pleiotropic cytokine with regard to its cellular sources and its actions. IL-33 is involved in the pathogenesis of brain diseases. Several factors account for the tumorigenicity of human gliomas, including cytokines and their receptors. The present study assessed the expression and prognostic significance of IL‑33 in human astroglial brain tumors. Protein levels of IL‑33 were determined by immunohistochemistry using a tissue microarray containing 95 human gliomas. mRNA expression data of IL‑33, as well as of its receptors, IL‑1 receptor‑like 1 protein and IL‑1 receptor accessory protein (IL1RAcP), were obtained from The Cancer Genome Atlas database. IL‑33 protein was expressed heterogeneously in tumor tissue, but was, however, not detected in normal brain tissue. There was no differential IL‑33 protein expression by tumor grade, while IL‑33 protein expression was associated with inferior survival in patients with recurrent glioblastomas. Interrogations of the TCGA database indicated that mRNA expression of IL‑33 and the IL‑33 receptors was heterogeneous, and that IL‑33 and IL1RAcP mRNA levels were correlated with the tumor grade. Elevated IL‑33 mRNA levels were associated with the inferior survival of glioblastoma patients. Therefore, IL‑33 may play an important role in the pathogenesis and prognosis of human gliomas.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gramatzki D, Frei K, Cathomas G, Moch H, Weller M and Mertz KD: Interleukin-33 in human gliomas: Expression and prognostic significance. Oncol Lett 12: 445-452, 2016
APA
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., & Mertz, K.D. (2016). Interleukin-33 in human gliomas: Expression and prognostic significance. Oncology Letters, 12, 445-452. https://doi.org/10.3892/ol.2016.4626
MLA
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., Mertz, K. D."Interleukin-33 in human gliomas: Expression and prognostic significance". Oncology Letters 12.1 (2016): 445-452.
Chicago
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., Mertz, K. D."Interleukin-33 in human gliomas: Expression and prognostic significance". Oncology Letters 12, no. 1 (2016): 445-452. https://doi.org/10.3892/ol.2016.4626