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Interleukin-33 in human gliomas: Expression and prognostic significance

  • Authors:
    • Dorothee Gramatzki
    • Karl Frei
    • Gieri Cathomas
    • Holger Moch
    • Michael Weller
    • Kirsten Diana Mertz
  • View Affiliations / Copyright

    Affiliations: Laboratory for Molecular Neuro‑Oncology, Department of Neurology, University Hospital Zurich, 8091 Zurich, Switzerland, Department of Neurosurgery, University Hospital Zurich, 8091 Zurich, Switzerland, Institute of Pathology Liestal, Cantonal Hospital Baselland, 4410 Liestal, Switzerland, Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, 8091 Zurich, Switzerland
    Copyright: © Gramatzki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 445-452
    |
    Published online on: May 25, 2016
       https://doi.org/10.3892/ol.2016.4626
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Abstract

Interleukin-33 (IL-33) is a nuclear and pleiotropic cytokine with regard to its cellular sources and its actions. IL-33 is involved in the pathogenesis of brain diseases. Several factors account for the tumorigenicity of human gliomas, including cytokines and their receptors. The present study assessed the expression and prognostic significance of IL‑33 in human astroglial brain tumors. Protein levels of IL‑33 were determined by immunohistochemistry using a tissue microarray containing 95 human gliomas. mRNA expression data of IL‑33, as well as of its receptors, IL‑1 receptor‑like 1 protein and IL‑1 receptor accessory protein (IL1RAcP), were obtained from The Cancer Genome Atlas database. IL‑33 protein was expressed heterogeneously in tumor tissue, but was, however, not detected in normal brain tissue. There was no differential IL‑33 protein expression by tumor grade, while IL‑33 protein expression was associated with inferior survival in patients with recurrent glioblastomas. Interrogations of the TCGA database indicated that mRNA expression of IL‑33 and the IL‑33 receptors was heterogeneous, and that IL‑33 and IL1RAcP mRNA levels were correlated with the tumor grade. Elevated IL‑33 mRNA levels were associated with the inferior survival of glioblastoma patients. Therefore, IL‑33 may play an important role in the pathogenesis and prognosis of human gliomas.
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View References

1 

Gramatzki D, Dehler S, Rushing EJ, Zaugg K, Hofer S, Yonekawa Y, Bertalanffy H, Valavanis A, Korol D, Rohrmann S, et al: Glioblastoma in the Canton of Zurich, Switzerland revisited: 2005 to 2009. Cancer. Apr 18–2016.(Epub ahead of print). View Article : Google Scholar

2 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Weller M, van den Bent M, Hopkins K, Tonn JC, Stupp R, Falini A, Cohen-Jonathan-Moyal E, Frappaz D, Henriksson R, Balana C, et al: EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol. 15:e395–e403. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Huse JT and Holland EC: Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma. Nat Rev Cancer. 10:319–331. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Charles NA, Holland EC, Gilbertson R, Glass R and Kettenmann H: The brain tumor microenvironment. Glia. 59:1169–1180. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Lin Y, Zhang G, Zhang J, Gao G, Li M, Chen Y, Wang J, Li G, Song SW, Qiu X, et al: A panel of four cytokines predicts the prognosis of patients with malignant gliomas. J Neurooncol. 114:199–208. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Prosniak M, Harshyne LA, Andrews DW, Kenyon LC, Bedelbaeva K, Apanasovich TV, Heber-Katz E, Curtis MT, Cotzia P and Hooper DC: Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers. Clin Cancer Res. 19:3776–3786. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Yeung YT, McDonald KL, Grewal T and Munoz L: Interleukins in glioblastoma pathophysiology: Implications for therapy. Br J Pharmacol. 168:591–606. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Zhu VF, Yang J, Lebrun DG and Li M: Understanding the role of cytokines in glioblastoma multiforme pathogenesis. Cancer Lett. 316:139–150. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, et al: The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature. 513:564–568. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Beltrán CJ, Núñez LE, Díaz-Jiménez D, Farfan N, Candia E, Heine C, López F, González MJ, Quera R and Hermoso MA: Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease. Inflamm Bowel Dis. 16:1097–1107. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Palmer G and Gabay C: Interleukin-33 biology with potential insights into human diseases. Nat Rev Rheumatol. 7:321–329. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Préfontaine D, Nadigel J, Chouiali F, Audusseau S, Semlali A, Chakir J, Martin JG and Hamid Q: Increased IL-33 expression by epithelial cells in bronchial asthma. J Allergy Clin Immunol. 125:752–754. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Byers DE, Alexander-Brett J, Patel AC, Agapov E, Dang-Vu G, Jin X, Wu K, You Y, Alevy Y, Girard JP, et al: Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. J Clin Invest. 123:3967–3982. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Kempf W, Zollinger T, Sachs M, Ullmer E, Cathomas G, Dirnhofer S and Mertz KD: Granulomas are a source of interleukin-33 expression in pulmonary and extrapulmonary sarcoidosis. Hum Pathol. 45:2202–2210. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Moulin D, Donzé O, Talabot-Ayer D, Mézin F, Palmer G and Gabay C: Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells. Cytokine. 40:216–225. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, et al: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 23:479–490. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Chackerian AA, Oldham ER, Murphy EE, Schmitz J, Pflanz S and Kastelein RA: IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 179:2551–2555. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Küchler AM, Pollheimer J, Balogh J, Sponheim J, Manley L, Sorensen DR, De Angelis PM, Scott H and Haraldsen G: Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation. Am J Pathol. 173:1229–1242. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Moussion C, Ortega N and Girard JP: The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: A novel ‘alarmin’? PLoS One. 3:e33312008. View Article : Google Scholar : PubMed/NCBI

21 

Carriere V, Roussel L, Ortega N, Lacorre DA, Americh L, Aguilar L, Bouche G and Girard JP: IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo. Proc Natl Acad Sci USA. 104:282–287. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Alves-Filho JC, Sônego F, Souto FO, Freitas A, Verri WA Jr, Auxiliadora-Martins M, Basile-Filho A, McKenzie AN, Xu D, Cunha FQ and Liew FY: Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection. Nat Med. 16:708–712. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Haraldsen G, Balogh J, Pollheimer J, Sponheim J and Küchler AM: Interleukin-33-cytokine of dual function or novel alarmin? Trends Immunol. 30:227–233. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Roussel L, Erard M, Cayrol C and Girard JP: Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket. EMBO Rep. 9:1006–1012. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Xiong Z, Thangavel R, Kempuraj D, Yang E, Zaheer S and Zaheer A: Alzheimer's disease: Evidence for the expression of interleukin-33 and its receptor ST2 in the brain. J Alzheimers Dis. 40:297–308. 2014.PubMed/NCBI

26 

Christophi GP, Gruber RC, Panos M, Christophi RL, Jubelt B and Massa PT: Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients. Clin Immunol. 142:308–319. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, Sonobe Y, Takeuchi H, Mizuno T and Suzumura A: Production and functions of IL-33 in the central nervous system. Brain Res. 1385:8–17. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA and Massa PT: Induction of IL-33 expression and activity in central nervous system glia. J Leukoc Biol. 84:631–643. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Han P, Mi WL and Wang YQ: Research progress on interleukin-33 and its roles in the central nervous system. Neurosci Bull. 27:351–357. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Kempuraj D, Khan MM, Thangavel R, Xiong Z, Yang E and Zaheer A: Glia maturation factor induces interleukin-33 release from astrocytes: Implications for neurodegenerative diseases. J Neuroimmune Pharmacol. 8:643–650. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Sun P, Ben Q, Tu S, Dong W, Qi X and Wu Y: Serum interleukin-33 levels in patients with gastric cancer. Dig Dis Sci. 56:3596–3601. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Bergis D, Kassis V, Ranglack A, Koeberle V, Piiper A, Kronenberger B, Zeuzem S, Waidmann O and Radeke HH: High serum levels of the interleukin-33 receptor soluble ST2 as a negative prognostic factor in hepatocellular carcinoma. Transl Oncol. 6:311–318. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Hu LA, Fu Y, Zhang DN and Zhang J: Serum IL-33 as a diagnostic and prognostic marker in non-small cell lung cancer. Asian Pac J Cancer Prev. 14:2563–2566. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Fang KM, Yang CS, Lin TC, Chan TC and Tzeng SF: Induced interleukin-33 expression enhances the tumorigenic activity of rat glioma cells. Neuro Oncol. 16:552–566. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Louis DN, Ohgaki H, Wiestler B and Cavenee WK: WHO Classification of Tumours of the Central Nervous System. IARC Press. Lyon: 2007.

36 

Cancer Genome Atlas Research Network: Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 455:1061–1068. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Gravendeel LA, Kouwenhoven MC, Gevaert O, de Rooi JJ, Stubbs AP, Duijm JE, Daemen A, Bleeker FE, Bralten LB, Kloosterhof NK, et al: Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res. 69:9065–9072. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Singhal G, Jaehne EJ, Corrigan F, Toben C and Baune BT: Inflammasomes in neuroinflammation and changes in brain function: A focused review. Front Neurosci. 8:3152014. View Article : Google Scholar : PubMed/NCBI

39 

Jovanovic IP, Pejnovic NN, Radosavljevic GD, Arsenijevic NN and Lukic ML: IL-33/ST2 axis in innate and acquired immunity to tumors. Oncoimmunology. 1:229–231. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Villarreal DO, Wise MC, Walters JN, Reuschel EL, Choi MJ, Obeng-Adjei N, Yan J, Morrow MP and Weiner DB: Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity. Cancer Res. 74:1789–1800. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Gao K, Li X and Zhang L, Bai L, Dong W, Gao K, Shi G, Xia X, Wu L and Zhang L: Transgenic expression of IL-33 activates CD8(+) T cells and NK cells and inhibits tumor growth and metastasis in mice. Cancer Lett. 335:463–471. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Curran CS and Bertics PJ: Eosinophils in glioblastoma biology. J Neuroinflammation. 9:112012. View Article : Google Scholar : PubMed/NCBI

43 

Hussain SF, Yang D, Suki D, Aldape K, Grimm E and Heimberger AB: The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol. 8:261–279. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Dong H, Zhang X and Qian Y: Mast cells and neuroinflammation. Med Sci Monit Basic Res. 20:200–206. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Skaper SD, Facci L and Giusti P: Mast cells, glia and neuroinflammation: Partners in crime? Immunology. 141:314–327. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Merk BC, Owens JL, Lopes MB, Silva CM and Hussaini IM: STAT6 expression in glioblastoma promotes invasive growth. BMC Cancer. 11:1842011. View Article : Google Scholar : PubMed/NCBI

47 

Choi YS, Choi HJ, Min JK, Pyun BJ, Maeng YS, Park H, Kim J, Kim YM and Kwon YG: Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production. Blood. 114:3117–3126. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Gadani SP, Walsh JT, Smirnov I, Zheng J and Kipnis J: The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury. Neuron. 85:703–709. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gramatzki D, Frei K, Cathomas G, Moch H, Weller M and Mertz KD: Interleukin-33 in human gliomas: Expression and prognostic significance. Oncol Lett 12: 445-452, 2016.
APA
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., & Mertz, K.D. (2016). Interleukin-33 in human gliomas: Expression and prognostic significance. Oncology Letters, 12, 445-452. https://doi.org/10.3892/ol.2016.4626
MLA
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., Mertz, K. D."Interleukin-33 in human gliomas: Expression and prognostic significance". Oncology Letters 12.1 (2016): 445-452.
Chicago
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., Mertz, K. D."Interleukin-33 in human gliomas: Expression and prognostic significance". Oncology Letters 12, no. 1 (2016): 445-452. https://doi.org/10.3892/ol.2016.4626
Copy and paste a formatted citation
x
Spandidos Publications style
Gramatzki D, Frei K, Cathomas G, Moch H, Weller M and Mertz KD: Interleukin-33 in human gliomas: Expression and prognostic significance. Oncol Lett 12: 445-452, 2016.
APA
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., & Mertz, K.D. (2016). Interleukin-33 in human gliomas: Expression and prognostic significance. Oncology Letters, 12, 445-452. https://doi.org/10.3892/ol.2016.4626
MLA
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., Mertz, K. D."Interleukin-33 in human gliomas: Expression and prognostic significance". Oncology Letters 12.1 (2016): 445-452.
Chicago
Gramatzki, D., Frei, K., Cathomas, G., Moch, H., Weller, M., Mertz, K. D."Interleukin-33 in human gliomas: Expression and prognostic significance". Oncology Letters 12, no. 1 (2016): 445-452. https://doi.org/10.3892/ol.2016.4626
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