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Article Open Access

miR-10b promotes invasion by targeting HOXD10 in colorectal cancer

  • Authors:
    • Yunfeng Wang
    • Zhen Li
    • Xuhong Zhao
    • Xiaoming Zuo
    • Zhihai Peng
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China, Department of Central Experiment Laboratory, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China, Department of Pathology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, P.R. China, Department of General Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 488-494
    |
    Published online on: May 25, 2016
       https://doi.org/10.3892/ol.2016.4628
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Abstract

Studies have shown that homeobox D10 (HOXD10) is the target gene of microRNA-10b (miR-10b) and is closely associated with the inhibition of cell migration and invasion. Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. The effect of miR‑10b on colorectal cancer (CRC) metastasis and the associated molecular mechanisms remain elusive. The present study aimed to investigate whether miR‑10b could promote invasion by targeting HOXD10 in CRC by exploring the association between miR‑10b and HOXD10 expression in CRC patients. The findings revealed that miR‑10b levels were elevated in the CRC specimens and significantly correlated with advanced clinical stage and lymph node metastasis. In addition, HOXD10 was a direct target of miR‑10b, and the increased expression of RhoC and downregulation of HOXD10 correlated with the increased expression level of miR‑10b. HOXD10 protein level was also markedly attenuated in lymph node metastasis‑positive tumor tissues compared with lymph node metastasis‑free tumor tissues. These findings suggest that miR‑10b may stimulate the upregulation of RhoC through targeting HOXD10, thus promoting the invasion and migration in CRC tumor.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Li Z, Zhao X, Zuo X and Peng Z: miR-10b promotes invasion by targeting HOXD10 in colorectal cancer. Oncol Lett 12: 488-494, 2016.
APA
Wang, Y., Li, Z., Zhao, X., Zuo, X., & Peng, Z. (2016). miR-10b promotes invasion by targeting HOXD10 in colorectal cancer. Oncology Letters, 12, 488-494. https://doi.org/10.3892/ol.2016.4628
MLA
Wang, Y., Li, Z., Zhao, X., Zuo, X., Peng, Z."miR-10b promotes invasion by targeting HOXD10 in colorectal cancer". Oncology Letters 12.1 (2016): 488-494.
Chicago
Wang, Y., Li, Z., Zhao, X., Zuo, X., Peng, Z."miR-10b promotes invasion by targeting HOXD10 in colorectal cancer". Oncology Letters 12, no. 1 (2016): 488-494. https://doi.org/10.3892/ol.2016.4628
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Li Z, Zhao X, Zuo X and Peng Z: miR-10b promotes invasion by targeting HOXD10 in colorectal cancer. Oncol Lett 12: 488-494, 2016.
APA
Wang, Y., Li, Z., Zhao, X., Zuo, X., & Peng, Z. (2016). miR-10b promotes invasion by targeting HOXD10 in colorectal cancer. Oncology Letters, 12, 488-494. https://doi.org/10.3892/ol.2016.4628
MLA
Wang, Y., Li, Z., Zhao, X., Zuo, X., Peng, Z."miR-10b promotes invasion by targeting HOXD10 in colorectal cancer". Oncology Letters 12.1 (2016): 488-494.
Chicago
Wang, Y., Li, Z., Zhao, X., Zuo, X., Peng, Z."miR-10b promotes invasion by targeting HOXD10 in colorectal cancer". Oncology Letters 12, no. 1 (2016): 488-494. https://doi.org/10.3892/ol.2016.4628
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