Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2016 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2016 Volume 12 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy

  • Authors:
    • Leszek Hawrylewicz
    • Wojciech Leszczyński
    • Agnieszka Namysł‑Kaletka
    • Iwona Bronclik
    • Jerzy Wydmański
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy and Brachytherapy Planning, Maria Sklodowska‑Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44‑101 Gliwice, Poland, Department of Radiotherapy, Maria Sklodowska‑Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44‑101 Gliwice, Poland
  • Pages: 692-698
    |
    Published online on: May 26, 2016
       https://doi.org/10.3892/ol.2016.4633
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to compare the techniques of dynamic intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT) in patients with gastric cancer. Implementation of the IMRT technique does not significantly affect the minimum and maximum dose levels in the planning target volume (PTV), but more effectively protects the critical organs. The study group consisted of 25 patients. The results of the analysis of the conformity index (CI) and the homogeneity index (HI) showed that the doses in the PTV regions were at a comparable level. The CI for the PTV was 0.95 for the 2‑field technique, 0.95 for the 3‑field technique, 0.96 for the 4‑field technique and 0.94 for the IMRT technique. The CIs for these techniques for the clinical target volume (CTV) were 0.96, 0.96, 0.97 and 0.96, respectively, and the CIs for the gross tumor volume (GTV) were 0.99, 0.99, 0.99 and 0.98, respectively. The HI values for the PTV were 1.12 for the 2‑field technique, 1.12 for the 3‑field technique, 1.09 for the 4‑field technique and 1.09 for the IMRT technique, and the HI values for the CTV were 1.12, 1.12, 1.09 and 1.08 for the same techniques, respectively. The HI values for the GTV were 1.09, 1.09, 1.07 and 1.06, respectively, which indicated significantly superior performance in the regions of healthy tissue. Statistical study was based on Friedman's rank analysis of variance to determine the level of reliability of the tested groups of variables (P<0.001). The present study demonstrated that the IMRT technique in the pre‑operative radiotherapy of gastric cancer patients results in superior treatment tolerance and reduces the risk of damage to healthy tissue that is in close proximity to the irradiated area.
View Figures

Figure 1

View References

1 

International Agency for Research on Cancer, World Health Organization: Globocan 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspxAccessed. August 09–2014

2 

Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F and Capocaccia R: EUROCARE Working Group: EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Reslts and commentary. Eur J Cancer. 45:931–991. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM and Martenson JA: Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 345:725–730. 2001. View Article : Google Scholar : PubMed/NCBI

4 

NCCN: Practice Guidelines in Oncology version 2. 2010.https://www.nccn.org/professionals/physician_gls/f_guidelines.aspAccessed. December 11–2012

5 

Zhang ZX, Gu XZ, Yin WB, Huang GJ, Zhang DW and Zhang RG: Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of adenocarcinoma of gastric cardia (ACG)-report on 370 patients. Int J Radiat Oncol Biol Phys. 42:929–934. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Sindelar WG and Kinsella TJ: Randomized trial of resection and intraoperative radiotherapy in locally advanced gastric cancer. Proc Ann Meet Am Soc Clin Oncol. 6:A3571987.

7 

Ito H, Clancy TE, Osteen RT, Swanson RS, Bueno R, Sugarbaker DJ, Ashley SW, Zinner MJ and Whang EE: Adenocarcinoma of the gastric cardia: What is optimal surgical approach? J Am Coll Surg. 199:880–886. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Ajani JA, Mansfield PF, Janjan N, Morris J, Pisters PW, Lynch PM, Feig B, Myerson R, Nivers R, Cohen DS and Gunderson LL: Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma. J Clin Oncol. 22:2774–2780. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Allal AS, Zwahlen D, Bründler MA, de Peyer R, Morel P, Huber O and Roth AD: Neoadjuvant radiochemotherapy for locally advanced gastric cancer: Long-term results of a phase I trial. Int J Radiat Oncol Biol Phys. 63:1286–1289. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Wydmański J, Suwinski R, Poltorak S, Maka B, Miszczyk L, Wolny E, Bielaczyc G and Zajusz A: The tolerance and efficacy of preoperative chemoradiotherapy followed by gastrectomy in operable gastric cancer, a phase II study. Radiother Oncol. 82:132–136. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Hallissey MT, Dunn JA, Ward LC and Allum WH: The second British stomach cancer group trial of adjuvant radiotherapy or chemotherapy in respectable gastric cancer: Five year follow-up. Lancet. 343:1309–1312. 1994. View Article : Google Scholar : PubMed/NCBI

12 

Huchet A, Caudry M, Belkacémi Y, Trouette R, Vendrely V, Causse N, Récaldini L, Atlan D and Maire JP: Volume-effect and radiotherapy [II] part II: Volume-effect and normal tissue. Cancer Radiother. 7:353–362. 2003.(In French). View Article : Google Scholar : PubMed/NCBI

13 

Soyfer V, Corn BW, Melamud A, Alani S, Tempelhof H, Agai R, Shmueli A, Figer A and Kovner F: Three-Dimensional non-coplanar conformal radiotherapy yields better results than traditional beam arrangements for adjuvant treatment of gastric cancer. Int J Radiat Oncol Biol Phys. 69:364–369. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Matzinger O, Gerber E, Bernstein Z, Maingon P, Haustermans K, Bosset JF, Gulyban A, Poortmans P, Collette L and Kuten A: EORTC-ROG expert opinion: Radiotherapy volume and treatment guidelines for neoadjuvant radiation of adenocarcinomas of the gastroesophageal junction and the stomach. Radiother Oncol. 92:164–175. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Edge BD, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC Cancer Staging Manual (7th). Springer-Verlag. New York, NY: 2010.

16 

Wydmański J and Mohanti BK: An appraisal of radiation therapy techniques for adjuvant and neoadjuvant therapy in gastric cancer. J Radiother Pract. 7:67–75. 2008. View Article : Google Scholar

17 

Feuvret L, Noël G, Mazeron JJ and Bey P: Conformity index: A review. Int J Radiat Oncol Biol Phys. 64:333–342. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Lomax NJ and Scheib SG: Quantifying the degree of conformity in radiosurgery treatment planning. Int J Radiat Oncol Biol Phys. 55:1409–1419. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Lefkopoulos D, Dejean C, El-Balma H, Platoni K, Grandjean P, Foulquier J and Schlienger M: Determination of dose-volumes parameters to characterise the conformity of stereotactic treatment plans. Proc. of the XIIIth Intern. Conf. on: Computers in Radiation Therapy (XIIIth ICCR, Heidelberg, Germany). 356–358. 2000.

20 

Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J and Farnan N: Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: Final report of RTOG protocol 90–05. Int J Radiat Oncol Biol Phys. 47:291–298. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Stanley J, Breitman K, Dunscombe P, Spencer DP and Lau H: Evaluation of stereotactic radiosurgery conformity indices for 170 target volumes in patients with brain metastases. J Appl Clin Med Phys. 12:34492011.PubMed/NCBI

22 

Morganti AG, Di Castelnuovo A, Massaccesi M, Cellini F, Cilla S, Macchia G, Forte P, Buwenge M, Digesu C, Ferro M, et al: Planning comparison between standart and conformal 3D techniques in post-operative radiotherapy of gastric cancer: A systematic review. Br J Radiol. 86:201302742013. View Article : Google Scholar : PubMed/NCBI

23 

Leong T, Willis D, Joon DL, Condron S, Hui A and Ngan SY: 3D conformal radiotherapy for gastric cancer-results of a comparative planning study. Radiother Oncol. 74:301–306. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Wieland P, Dobler B, Mai S, Hermann B, Tiefenbacher U, Steil V, Wenz F and Lohr F: IMRT for postoperative treatment of gastric cancer: Covering large target volumes in the upper abdomen: A comparison of step-and-shoot and an arc therapy approach. Int J Radiat Oncol Biol Phys. 59:1236–1244. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Minn AY, Hsu A, La T, Kunz P, Fisher GA, Ford JM, Norton JA, Visser B, Goodman KA, Koong AC and Chang DT: Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer. Cancer. 116:3943–3952. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Ma H, Han J, Zhang T and Ke Y: Comparison of dosiology between three dimensional conformal and intensity-modulated radiotherapies (5 and 7 fields) in gastric cancer post-surgery. J Huazhong Univ Sci Technolog Med Sci. 33:759–764. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hawrylewicz L, Leszczyński W, Namysł‑Kaletka A, Bronclik I and Wydmański J: Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy. Oncol Lett 12: 692-698, 2016.
APA
Hawrylewicz, L., Leszczyński, W., Namysł‑Kaletka, A., Bronclik, I., & Wydmański, J. (2016). Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy. Oncology Letters, 12, 692-698. https://doi.org/10.3892/ol.2016.4633
MLA
Hawrylewicz, L., Leszczyński, W., Namysł‑Kaletka, A., Bronclik, I., Wydmański, J."Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy". Oncology Letters 12.1 (2016): 692-698.
Chicago
Hawrylewicz, L., Leszczyński, W., Namysł‑Kaletka, A., Bronclik, I., Wydmański, J."Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy". Oncology Letters 12, no. 1 (2016): 692-698. https://doi.org/10.3892/ol.2016.4633
Copy and paste a formatted citation
x
Spandidos Publications style
Hawrylewicz L, Leszczyński W, Namysł‑Kaletka A, Bronclik I and Wydmański J: Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy. Oncol Lett 12: 692-698, 2016.
APA
Hawrylewicz, L., Leszczyński, W., Namysł‑Kaletka, A., Bronclik, I., & Wydmański, J. (2016). Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy. Oncology Letters, 12, 692-698. https://doi.org/10.3892/ol.2016.4633
MLA
Hawrylewicz, L., Leszczyński, W., Namysł‑Kaletka, A., Bronclik, I., Wydmański, J."Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy". Oncology Letters 12.1 (2016): 692-698.
Chicago
Hawrylewicz, L., Leszczyński, W., Namysł‑Kaletka, A., Bronclik, I., Wydmański, J."Protection of organs at risk during neoadjuvant chemoradiotherapy for gastric cancer based on a comparison between conformal and intensity-modulated radiation therapy". Oncology Letters 12, no. 1 (2016): 692-698. https://doi.org/10.3892/ol.2016.4633
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team