Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance (Review)

  • Authors:
    • Wei‑Liang Sun
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  • Published online on: May 30, 2016     https://doi.org/10.3892/ol.2016.4644
  • Pages: 367-374
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Abstract

Increasing studies suggest that autophagy has a protective role in cancer treatment and may even be involved in chemotherapy resistance. Nevertheless, the mechanism of autophagy in cancer treatment and drug resistance has not yet been established. There is a complex association between autophagy and apoptosis. Accordingly, these two processes can mutually regulate and transform to determine the fate of a cell, depending on the context. Activating molecule in Beclin 1‑regulated autophagy protein 1 (Ambra1) is an important factor at the crossroad between autophagy and apoptosis. The expression level and intracellular distributions of Ambra1 may control the balance and conversion between autophagy and apoptosis, and modify the effectiveness of chemotherapy. Therefore, Ambra1 may provide a novel target for cancer treatment, particularly for overcoming anticancer drug resistance. The present review focuses on the role of Ambra1 in autophagy and apoptosis and assesses the implications for cell survival and chemotherapy resistance.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Sun WL: Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance (Review). Oncol Lett 12: 367-374, 2016
APA
Sun, W. (2016). Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance (Review). Oncology Letters, 12, 367-374. https://doi.org/10.3892/ol.2016.4644
MLA
Sun, W."Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance (Review)". Oncology Letters 12.1 (2016): 367-374.
Chicago
Sun, W."Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance (Review)". Oncology Letters 12, no. 1 (2016): 367-374. https://doi.org/10.3892/ol.2016.4644