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Article

Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia

  • Authors:
    • Wangqiang Hu
    • Xiaoxia Wang
    • Rongrong Yang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
  • Pages: 591-596
    |
    Published online on: June 1, 2016
       https://doi.org/10.3892/ol.2016.4657
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Abstract

Despite the outstanding advances made over the past decade regarding our knowledge of acute leukemia (AL), relapsed AL remains to be associated with a dismal prognosis. A better understanding of AL relapse and monitoring of the D‑dimer and lactate dehydrogenase (LDH) plasma levels following chemotherapy may aid clinicians in determining whether relapse may occur in the subsequent phases of the disease. The present study evaluated D‑dimer and LDH levels in 204 patients with relapsed AL. Data were collected at the initial onset of AL, at complete remission (CR) and in patients with relapsed AL. D‑dimer plasma levels were significantly increased in patients with initial AL and in patients with relapsed AL (P=0.005 and P=0.007, respectively) but not in those with CR. LDH levels were significantly increased in AL patients at the initial onset of disease and at relapse compared with patients achieving CR, irrespective of cell type. Plasma prothrombin time, activated partial thromboplastin time and fibrinogen levels were not significantly different across patients (with the exception of acute promyelocytic leukemia patients) at the initial onset, relapsed AL or CR. Routine hematological parameters (white blood cell count, hemoglobin, platelet count) were significantly different at the initial onset of AL (P=0.002, P<0.001 and P=0.001, respectively) and during relapsed AL (P=0.009, P=0.003 and P<0.001, respectively) compared with patients achieving CR, suggesting an association between D‑dimer, LDH and relapsed AL. These results also indicate that determination of D‑dimer and LDH levels may be useful for predicting the probability of relapse during chemotherapy, but should also be combined with routine hematological parameters.
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1 

Deschler B and Lübbert M: Acute myeloid leukemia: Epidemiology and etiology. Cancer. 107:2099–2107. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Lo-Coco F, Ammatuna E, Montesinos P and Sanz MA: Acute promyelocytic leukemia: Recent advances in diagnosis and management. Semin Oncol. 35:401–409. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Inagaki J, Fukano R, Noguchi M, Kurauchi K, Tanioka S and Okamura J: Hematopoietic stem cell transplantation following unsuccessful salvage treatment for relapsed acute lymphoblastic leukemia in children. Pediatr Blood Cancer. 62:674–679. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Cui L, Gao C, Zhang RD, Jiao Y, Li WJ, Zhao XX, Liu SG, Yue ZX, Zheng HY, Deng GR, et al: Low expressions of ARS2 and CASP8AP2 predict relapse and poor prognosis in pediatric acute lymphoblastic leukemia patients treated on China CCLG-ALL 2008 protocol. Leuk Res. 39:115–123. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Arakawa Y, Koh K, Aoki T, Kubota Y, Oyama R, Mori M, Hayashi M and Hanada R: Clofarabine-based combination chemotherapy for relapse and refractory childhood acute lymphoblastic leukemia. Rinsho Ketsueki. 55:2316–2319. 2014.PubMed/NCBI

6 

Bruedigam C, Bagger FO, Heidel FH, Kuhn Paine C, Guignes S, Song A, Austin R, Vu T, Lee E, Riyat S, et al: Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell. 15:775–790. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Ilyas AM, Ahmad S, Faheem M, Naseer MI, Kumosani TA, Al-Qahtani MH, Gari M and Ahmed F: Next generation sequencing of acute myeloid leukemia: Influencing prognosis. BMC Genomics. 16(Suppl 1): S52015. View Article : Google Scholar : PubMed/NCBI

8 

Itzykson R, Thépot S, Berthon C, Delaunay J, Bouscary D, Cluzeau T, Turlure P, Prébet T, Dartigeas C, Marolleau JP, et al: Azacitidine for the treatment of relapsed and refractory AML in older patients. Leuk Res. 39:124–130. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Rashidi A and Cashen AF: A cytogenetic model predicts relapse risk and survival in patients with acute myeloid leukemia undergoing hematopoietic stem cell transplantation in morphologic complete remission. Leuk Res. 39:77–81. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Martelli MF, Di Ianni M, Ruggeri L, Falzetti F, Carotti A, Terenzi A, Pierini A, Massei MS, Amico L, Urbani E, et al: HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse. Blood. 124:638–644. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Byrd JC, Mrozek K, Dodge RK, Carroll AJ, Edwards CG, Arthur DC, Pettenati MJ, Patil SR, Rao KW, Watson MS, et al: Cancer and Leukemia Group B (CALGB 8461): Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461). Blood. 100:4325–4336. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Thakkar SG, Fu AZ, Sweetenham JW, McIver ZA, Mohan SR, Ramsingh G, Advani AS, Sobecks R, Rybicki L, Kalaycio M and Sekeres MA: Survival and predictors of outcome in patients with acute leukemia admitted to the intensive care unit. Cancer. 112:2233–2240. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Benyo M, Flasko T, Molnar Z, Kerenyi A, Batta Z, Jozsa T and Harsfalvi J: Follow-up of thrombin generation after prostate cancer surgery: Global test for increased hypercoagulability. PLoS One. 7:e512992012. View Article : Google Scholar : PubMed/NCBI

14 

Diao D, Zhu K, Wang Z, Cheng Y, Li K, Pei L and Dang C: Prognostic value of the D-dimer test in oesophageal cancer during the perioperative period. J Surg Oncol. 108:34–41. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Kachel P, Trojanowicz B, Sekulla C, Prenzel H, Dralle H and Hoang-Vu C: Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue. BMC Cancer. 15:1402015. View Article : Google Scholar : PubMed/NCBI

16 

Park HY, Suh GY, Jeon K, Koh WJ, Chung MP, Kim H, Kwon OJ, Kim K, Jang JH, Jung CW, et al: Outcome and prognostic factors of patients with acute leukemia admitted to the intensive care unit for septic shock. Leuk Lymphoma. 49:1929–1934. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR and Sultan C: Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7). A report of the French-American-British Cooperative Group. Ann Int Med. 103:460–462. 1985. View Article : Google Scholar : PubMed/NCBI

18 

Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellström-Lindberg E, Tefferi A and Bloomfield CD: The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes. Blood. 114:937–951. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Danese E, Montagnana M, Cervellin G and Lippi G: Hypercoagulability, D-dimer and atrial fibrillation: An overview of biological and clinical evidence. Ann Med. 46:364–371. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Lee K, Kim JE, Kwon J, Kim I, Yoon SS, Park S, Han KS and Kim HK: Poor prognosis of hypocoagulability assessed by thrombin generation assay in disseminated intravascular coagulation. Blood Coagul Fibrinolysis. 25:241–247. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Sartori M, Migliaccio L, Favaretto E, Cini M, Legnani C, Palareti G and Cosmi B: D-dimer for the diagnosis of upper extremity deep and superficial venous thrombosis. Thromb Res. 135:673–678. 2015. View Article : Google Scholar : PubMed/NCBI

22 

van der Hulle T, Tan M, den Exter PL, Mol GC, del Iglesias Sol A, van de Ree MA, Huisman MV and Klok FA: Selective D-dimer testing for the diagnosis of acute deep vein thrombosis: A validation study. J Thromb Haemost. 11:2184–2186. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Yoon CW, Kim SJ, Bang OY, Chung CS, Lee KH and Kim GM: Premorbid warfarin use and lower D-dimer levels are associated with a spontaneous early improvement in an atrial fibrillation-related stroke. J Thromb Haemost. 10:2394–2396. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Sartori M, Cosmi B, Legnani C, Favaretto E, Valdré L, Guazzaloca G, Rodorigo G, Cini M and Palareti G: The Wells rule and D-dimer for the diagnosis of isolated distal deep vein thrombosis. J Thromb Haemost. 10:2264–2269. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Han X, Sheng X, Jones HM, Jackson AL, Kilgore J, Stine JE, Schointuch MN, Zhou C and Bae-Jump VL: Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells. J Hematol Oncol. 8:22015. View Article : Google Scholar : PubMed/NCBI

26 

Augoff K, Hryniewicz-Jankowska A and Tabola R: Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer. Cancer Lett. 358:1–7. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Dowling P, Pollard D, Larkin A, Henry M, Meleady P, Gately K, O'Byrne K, Barr MP, Lynch V, Ballot J, et al: Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer. Mol Biosyst. 11:743–752. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Choudhry A and DeLoughery TG: Bleeding and thrombosis in acute promyelocytic leukemia. Am J Hematol. 87:596–603. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Chang H, Kuo MC, Shih LY, Dunn P, Wang PN, Wu JH, Lin TL, Hung YS and Tang TC: Clinical bleeding events and laboratory coagulation profiles in acute promyelocytic leukemia. Eur J Haematol. 88:321–328. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Asakura H, Takahashi H, Tsuji H, Matsushita T, Ninomiya H, Honda G, Mimuro J, Eguchi Y, Kitajima I and Sakata Y: Post-marketing surveillance of thrombomodulin alfa, a novel treatment of disseminated intravascular coagulation-safety and efficacy in 1,032 patients with hematologic malignancy. Thromb Res. 133:364–370. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Mego M, Zuo Z, Gao H, Cohen EN, Giordano A, Tin S, Anfossi S, Jackson S, Woodward W, Ueno NT, et al: Circulating tumour cells are linked to plasma D-dimer levels in patients with metastatic breast cancer. Thromb Haemost. 113:593–598. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Gomes M and Khorana AA: Risk assessment for thrombosis in cancer. Semin Thromb Hemost. 40:319–324. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Yanada M, Matsushita T, Suzuki M, Kiyoi H, Yamamoto K, Kinoshita T, Kojima T, Saito H and Naoe T: Disseminated intravascular coagulation in acute leukemia: Clinical and laboratory features at presentation. Eur J Haematol. 77:282–287. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Hess EP and Sztajnkrycer MD: Images in emergency medicine. Acute leukemia with blast crisis, disseminated intravascular coagulation, and intraparenchymal hemorrhage. Ann Emerg Med. 46:314–322. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Tanaka M and Yamanishi H: The expression of tissue factor antigen and activity on the surface of leukemic cells. Leuk Res. 17:103–111. 1993. View Article : Google Scholar : PubMed/NCBI

36 

Jácomo RH, Santana-Lemos BA, Lima AS, Assis PA, Lange AP, Figueiredo-Pontes LL, Oliveira LO, Bassi SC, Benício MT, Baggio MS, et al: Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia. Blood. 120:207–213. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Marchetti M, Russo L, Balducci D and Falanga A: All trans-retinoic acid modulates the procoagulant activity of human breast cancer cells. Thromb Res. 128:368–374. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Marchetti M, Diani E, ten Cate H and Falanga A: Characterization of the thrombin generation potential of leukemic and solid tumor cells by calibrated automated thrombography. Haematologica. 97:1173–1180. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Ohkawara H, Ishibashi T, Sugimoto K, Ikeda K, Ogawa K and Takeishi Y: Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-α-induced procoagulant activity and apoptosis in endothelial cells. PLoS One. 9:e1056972014. View Article : Google Scholar : PubMed/NCBI

40 

Poovassery JS, Sarr D, Smith G, Nagy T and Moore JM: Malaria-induced murine pregnancy failure: Distinct roles for IFN-gamma and TNF. J Immunol. 183:5342–5349. 2009. View Article : Google Scholar : PubMed/NCBI

41 

de Menezes YA, Félix-Silva J, da Silva-Júnior AA, Rebecchi IM, de Oliveira AS, Uchoa AF and Fernandes-Pedrosa Mde F: Protein-rich fraction of Cnidoscolus urens (L.) Arthur leaves: Enzymatic characterization and procoagulant and fibrinogenolytic activities. Molecules. 19:3552–3569. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Gansler J, Preissner KT and Fischer S: Influence of proinflammatory stimuli on the expression of vascular ribonuclease 1 in endothelial cells. FASEB J. 28:752–760. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Zucker S, Mirza H, Conner CE, Lorenz AF, Drews MH, Bahou WF and Jesty J: Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: Conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferation. Int J Cancer. 75:780–786. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Hawiger J, Veach RA, Liu XY, Timmons S and Ballard DW: IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells. Blood. 94:1711–1716. 1999.PubMed/NCBI

45 

Ma J, Duffy MR, Deng L, Dakin RS, Uil T, Custers J, Kelly SM, McVey JH, Nicklin SA and Baker AH: Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo. PLoS Pathog. 11:e10046732015. View Article : Google Scholar : PubMed/NCBI

46 

Velasco F, Torres A, Rojas R, Alvarez MA, Gomez P and Castillo D: Increase in the D-dimer levels during treatment in patients with acute myelogenous leukemia. Haemostasis. 22:117–123. 1992.PubMed/NCBI

47 

Cortelazzo S, Ponzoni M, Ferreri AJ and Hoelzer D: Lymphoblastic lymphoma. Crit Rev Oncol Hematol. 79:330–343. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Rao D, Ghalaut VS, Ghalaut PS and Rao S: Case series: CSF LDH, proteins and electrolyte levels in patients of acute lymphocytic leukemia. Clin Chim Acta. 413:1045–1048. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Thomas X, Danaïla C, Le QH, Sebban C, Troncy J, Charrin C, Lhéritier V, Michallet M, Magaud JP and Fiere D: Long-term follow-up of patients with newly diagnosed adult acute lymphoblastic leukemia: A single institution experience of 378 consecutive patients over a 21-year period. Leukemia. 15:1811–1822. 2001. View Article : Google Scholar : PubMed/NCBI

50 

Yeh CH, Tseng R, Hannah A, Estrov Z, Estey E, Kantarjian H and Albitar M: Clinical correlation of circulating heat shock protein 70 in acute leukemia. Leuk Res. 34:605–609. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Suvajdžić N, Cvetković Z, Dorđević V, Kraguljac-Kurtović N, Stanisavljević D, Bogdanović A, Djunić I, Colović N, Vidović A, Elezović I and Tomin D: Prognostic factors for therapy-related acute myeloid leukaemia (t-AML)-a single centre experience. Biomed Pharmacother. 66:285–292. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Litzow MR, Othus M, Cripe LD, Gore SD, Lazarus HM, Lee SJ, Bennett JM, Paietta EM, Dewald GW, Rowe JM, et al: Failure of three novel regimens to improve outcome for patients with relapsed or refractory acute myeloid leukaemia: A report from the Eastern Cooperative Oncology Group. Br J Haematol. 148:217–225. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Shiozawa Y, Takita J, Kato M, Sotomatsu M, Koh K, Ida K and Hayashi Y: Prognostic significance of leukopenia in childhood acute lymphoblastic leukemia. Oncol Lett. 7:1169–1174. 2014.PubMed/NCBI

54 

Hossain MJ, Xie L and Caywood EH: Prognostic factors of childhood and adolescent acute myeloid leukemia (AML) survival: Evidence from four decades of US population data. Cancer Epidemiol. 39:720–726. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu W, Wang X and Yang R: Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia. Oncol Lett 12: 591-596, 2016.
APA
Hu, W., Wang, X., & Yang, R. (2016). Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia. Oncology Letters, 12, 591-596. https://doi.org/10.3892/ol.2016.4657
MLA
Hu, W., Wang, X., Yang, R."Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia". Oncology Letters 12.1 (2016): 591-596.
Chicago
Hu, W., Wang, X., Yang, R."Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia". Oncology Letters 12, no. 1 (2016): 591-596. https://doi.org/10.3892/ol.2016.4657
Copy and paste a formatted citation
x
Spandidos Publications style
Hu W, Wang X and Yang R: Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia. Oncol Lett 12: 591-596, 2016.
APA
Hu, W., Wang, X., & Yang, R. (2016). Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia. Oncology Letters, 12, 591-596. https://doi.org/10.3892/ol.2016.4657
MLA
Hu, W., Wang, X., Yang, R."Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia". Oncology Letters 12.1 (2016): 591-596.
Chicago
Hu, W., Wang, X., Yang, R."Evaluation of D‑dimer and lactate dehydrogenase plasma levels in patients with relapsed acute leukemia". Oncology Letters 12, no. 1 (2016): 591-596. https://doi.org/10.3892/ol.2016.4657
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