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Case Report

Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature

  • Authors:
    • Jiujun Pu
    • Zhiming Wang
    • Hui Zhou
    • Ailing Zhong
    • Kai Jin
    • Lunliang Ruan
    • Gang Yang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 410000, P.R. China
  • Pages: 585-590
    |
    Published online on: June 1, 2016
       https://doi.org/10.3892/ol.2016.4673
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Abstract

Only a few cases of double or multiple pituitary adenomas have previously been reported in the literature; however, isolated double adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas are even more rare. The present study reports a rare case of a 50‑year‑old female patient who presented with typical clinical features of Cushing's disease and was diagnosed with isolated double ACTH‑secreting pituitary adenomas. Endocrinological examination revealed an ACTH‑producing pituitary adenoma, and preoperative magnetic resonance imaging (MRI) demonstrated a microadenoma with a lower intensity on the right side of the pituitary gland. The patient underwent endoscopic endonasal transsphenoidal surgery, which revealed another pituitary tumor in the left side of the pituitary gland. The two, clearly separated, pituitary adenomas identified in the same gland were completely resected. Immunohistochemistry and pathology revealed that the clearly separated double pituitary adenomas were positive for ACTH, thyroid‑stimulating, growth and prolactin hormones. Postoperatively, the levels of ACTH and cortisol hormone decreased rapidly. The case reported in the present study is considerably rare, due to the presence of a second pituitary adenoma in the same gland, which was not detected by preoperative MRI scan, but was noticed during surgery. Intraoperative evaluation may be important in the identification of double or multiple pituitary adenomas.
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Copy and paste a formatted citation
Spandidos Publications style
Pu J, Wang Z, Zhou H, Zhong A, Jin K, Ruan L and Yang G: Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature. Oncol Lett 12: 585-590, 2016.
APA
Pu, J., Wang, Z., Zhou, H., Zhong, A., Jin, K., Ruan, L., & Yang, G. (2016). Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature. Oncology Letters, 12, 585-590. https://doi.org/10.3892/ol.2016.4673
MLA
Pu, J., Wang, Z., Zhou, H., Zhong, A., Jin, K., Ruan, L., Yang, G."Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature". Oncology Letters 12.1 (2016): 585-590.
Chicago
Pu, J., Wang, Z., Zhou, H., Zhong, A., Jin, K., Ruan, L., Yang, G."Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature". Oncology Letters 12, no. 1 (2016): 585-590. https://doi.org/10.3892/ol.2016.4673
Copy and paste a formatted citation
x
Spandidos Publications style
Pu J, Wang Z, Zhou H, Zhong A, Jin K, Ruan L and Yang G: Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature. Oncol Lett 12: 585-590, 2016.
APA
Pu, J., Wang, Z., Zhou, H., Zhong, A., Jin, K., Ruan, L., & Yang, G. (2016). Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature. Oncology Letters, 12, 585-590. https://doi.org/10.3892/ol.2016.4673
MLA
Pu, J., Wang, Z., Zhou, H., Zhong, A., Jin, K., Ruan, L., Yang, G."Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature". Oncology Letters 12.1 (2016): 585-590.
Chicago
Pu, J., Wang, Z., Zhou, H., Zhong, A., Jin, K., Ruan, L., Yang, G."Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature". Oncology Letters 12, no. 1 (2016): 585-590. https://doi.org/10.3892/ol.2016.4673
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