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SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway

  • Authors:
    • Yanan Wang
    • Juanxiu Qin
    • Qian Liu
    • Xufen Hong
    • Tianming Li
    • Yuanjun Zhu
    • Lei He
    • Bing Zheng
    • Min Li
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200240, P.R. China, Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1329-1336
    |
    Published online on: June 7, 2016
       https://doi.org/10.3892/ol.2016.4681
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and has an extremely poor prognosis. Surgical resection is always inapplicable to HCC patients diagnosed at an advanced tumor stage. The mechanisms underlying HCC cell proliferation remain obscure. In the present study, SWItch/sucrose nonfermentable catalytic subunit SNF2 (SNF2H) expression was tested in HCC tissues and Wnt/β-catenin pathway activation upon overexpression of SNF2H or knockdown of SNF2H expression was investigated in cultured HCC cells. It was demonstrated that SNF2H is a vital factor for HCC growth. The SNF2H expression level is increased in HCC tissues compared with paratumoral liver tissues. SNF2H promotes HCC cell proliferation and colony formation ability in vitro. SNF2H may increase the protein level of β‑catenin and enhance its nuclear accumulation in HCC cells, thereby leading to the activation of the Wnt/β‑catenin signaling pathway. In conclusion, the present results indicate that SNF2H plays a vital role in HCC cell growth, suggesting that SNF2H may be a promising therapeutic target for HCC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Qin J, Liu Q, Hong X, Li T, Zhu Y, He L, Zheng B and Li M: SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway. Oncol Lett 12: 1329-1336, 2016.
APA
Wang, Y., Qin, J., Liu, Q., Hong, X., Li, T., Zhu, Y. ... Li, M. (2016). SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway. Oncology Letters, 12, 1329-1336. https://doi.org/10.3892/ol.2016.4681
MLA
Wang, Y., Qin, J., Liu, Q., Hong, X., Li, T., Zhu, Y., He, L., Zheng, B., Li, M."SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway". Oncology Letters 12.2 (2016): 1329-1336.
Chicago
Wang, Y., Qin, J., Liu, Q., Hong, X., Li, T., Zhu, Y., He, L., Zheng, B., Li, M."SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway". Oncology Letters 12, no. 2 (2016): 1329-1336. https://doi.org/10.3892/ol.2016.4681
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Qin J, Liu Q, Hong X, Li T, Zhu Y, He L, Zheng B and Li M: SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway. Oncol Lett 12: 1329-1336, 2016.
APA
Wang, Y., Qin, J., Liu, Q., Hong, X., Li, T., Zhu, Y. ... Li, M. (2016). SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway. Oncology Letters, 12, 1329-1336. https://doi.org/10.3892/ol.2016.4681
MLA
Wang, Y., Qin, J., Liu, Q., Hong, X., Li, T., Zhu, Y., He, L., Zheng, B., Li, M."SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway". Oncology Letters 12.2 (2016): 1329-1336.
Chicago
Wang, Y., Qin, J., Liu, Q., Hong, X., Li, T., Zhu, Y., He, L., Zheng, B., Li, M."SNF2H promotes hepatocellular carcinoma proliferation by activating the Wnt/β-catenin signaling pathway". Oncology Letters 12, no. 2 (2016): 1329-1336. https://doi.org/10.3892/ol.2016.4681
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