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Article

Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection

  • Authors:
    • Tomonori Kato
    • Akira Komiya
    • Akihiro Morii
    • Hiroaki Iida
    • Takatoshi Ito
    • Hideki Fuse
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama 930‑0194, Japan
  • Pages: 1132-1138
    |
    Published online on: June 9, 2016
       https://doi.org/10.3892/ol.2016.4693
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Abstract

Saturation prostate biopsy protocols have been developed to improve the prostate cancer (PCa) detection rate, particularly in the setting of repeat biopsies. The present study attempted to clarify the association between PCa detection and various risk factors in repeat saturation biopsies. A retrospective analysis was conducted on 78 Japanese patients for whom findings had caused suspicion of PCa despite previous negative prostate biopsies, and who consecutively underwent a 24‑core transperineal repeat biopsy at Toyama University Hospital (Toyama, Japan). PCa was confirmed histologically in 16 of the 78 patients (20.5%). A univariate analysis revealed that the prostate‑specific antigen (PSA) level at repeat biopsy was higher (P<0.01), the fPSA/tPSA ratio was lower (P=0.04), the total prostate volume was smaller (P=0.01) and the PSA density was higher (P<0.01) in PCa patients than in patients with benign prostatic disease (BPD). Histological inflammation was more frequently observed in BPD patients than in PCa patients (P<0.01). A multivariate analysis revealed that histological inflammation was the only independent predictor of the presence of a malignant lesion on repeat biopsy (odds ratio, 0.027; P=0.01). It must be considered that inflammation may cause a PSA increase in some patients with a negative initial biopsy, leading to unnecessary repeat biopsy.
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1 

Ouyang RC, Kenwright DN, Nacey JN and Delahunt B: The presence of atypical small acinar proliferation in prostate needle biopsy is predictive of carcinoma on subsequent biopsy. BJU Int. 87:70–74. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Hodge KK, McNeal JE, Terris MK and Stamey TA: Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate. J Urol. 142:71–75. 1989.PubMed/NCBI

3 

Rabbani F, Stroumbakis N, Kava BR, Cookson MS and Fair WR: Incidence and clinical significance of false-negative sextant prostate biopsies. J Urol. 159:1247–1250. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Norberg M, Egevad L, Holmberg L, Sparèn P, Norlèn BJ and Busch C: The sextant protocol for ultrasound-guided core biopsies of the prostate underestimates the presence of cancer. Urology. 50:562–566. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Pepe P and Aragona F: Prostate needle biopsy: 12 vs. 18 cores - is it necessary? Urol Int. 74:19–22. 2005.PubMed/NCBI

6 

Ficarra V, Novella G, Novara G, Galfano A, Pea M, Martignoni G and Artibani W: The potential impact of prostate volume in the planning of optimal number of cores in the systematic transperineal prostate biopsy. Eur Urol. 48:932–937. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, et al: Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 360:1320–1328. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Andriole GL, Crawford ED, Grubb RL III, Buys SS, Chia D, Church TR, Fouad MN, Gelmann EP, Kvale PA, Reding DJ, et al: Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 360:1310–1319. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Abdollah F, Novara G, Briganti A, Scattoni V, Raber M, Roscigno M, Suardi N, Gallina A, Artibani W, Ficarra V, et al: Transrectal versus transperineal saturation rebiopsy of the prostate: Is there a difference in cancer detection rate? Urology. 77:921–925. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Merrick GS, Gutman S, Andreini H, Taubenslag W, Lindert DL, Curtis R, Adamovich E, Anderson R, Allen Z, Butler W and Wallner K: Prostate cancer distribution in patients diagnosed by transperineal template-guided saturation biopsy. Eur Urol. 52:715–723. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Borboroglu PG, Corner SW, Riffenburgh RH and Amling CL: Extensive repeat transrectal ultrasound-guided prostate biopsy in patient with previous benign sextant biopsies. J Urol. 163:158–162. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Stewart CS, Leibovich BC, Weaver AL and Lieber MM: Prostate cancer diagnosis using a saturation needle biopsy technique after previous negative sextant biopsies. J Urol. 166:86–92. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Morote J, Lopez M, Encabo G and de Torres IM: Effect of inflammation and benign prostatic enlargement on total and percent free serum prostatic specific antigen. Eur Urol. 37:537–540. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Kato T, Suzuki H, Komiya A, Imamoto T, Naya Y, Tobe T and Ichikawa T: Clinical significance of urinary white blood cell count and serum C-reactive protein level for detection of non-palpable prostate cancer. Int J Urol. 13:915–919. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Hellmann F, Verdi M, Schlemper BR Jr and Caponi S: 50th anniversary of the Declaration of Helsinki: The double standard was introduced. Arch Med Res. 45:600–601. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Epstein JI, Allsbrook WC Jr, Amin MB and Egevad LL: ISUP Grading Committee: The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of prostatic carcinoma. Am J Surg Pathol. 29:1228–1242. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Krieger JN, Nyberg L Jr and Nickel JC: NIH consensus definition and classification of prostatitis. JAMA. 282:236–237. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Tosoian JJ, Trock BJ, Landis P, Feng Z, Epstein JI, Partin AW, Walsh PC and Carter HB: Active surveillance program for prostate cancer: An update of the Johns Hopkins experience. J Clin Oncol. 29:2185–2190. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Oesterling JE: Prostate specific antigen: A critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J Urol. 145:907–923. 1991.PubMed/NCBI

20 

Kawakami S, Kihara K, Fujii Y, Masuda H, Kobayashi T and Kageyama Y: Transrectal ultrasound-guided transperineal 14-core systematic biopsy detects apico-anterior cancer foci of T1c prostate cancer. Int J Urol. 11:613–618. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Shannon BA, McNeal JE and Cohen RJ: Transition zone carcinoma of the prostate gland: A common indolent tumor type that occasionally manifests aggressive behaviour. Pathology. 35:467–471. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Zaytoun OM, Moussa AS, Gao T, Fareed K and Jones JS: Office-based transrectal saturation biopsy improves prostate cancer detection compared to extended biopsy in the repeat biopsy population. J Urol. 186:850–854. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Bastian PJ, Mangold LA, Epstein JI and Partin AW: Characteristics of insignificant clinical T1c prostate tumors. A contemporary analysis. Cancer. 101:2001–2005. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Epstein JI, Sanderson H, Carter HB and Scharfstein DO: Utility of saturation biopsy to predict insignificant cancer at radical prostatectomy. Urology. 66:356–360. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Gann PH, Fought A, Deaton R, Catalona WJ and Vonesh E: Risk factors for prostate cancer detection after a negative biopsy: A novel multivariable longitudinal approach. J Clin Oncol. 28:1714–1720. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Djavan B, Fong YK, Ravery V, Remzi M, Horninger W, Susani M, Kreuzer S, Boccon-Gibod L, Bartsch G and Marberger M: Are repeat biopsies required in men with PSA levels < or =4 ng/ml? A multi-institutional prospective European study. Eur Urol. 47:38–44. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Brawer MK: The influence of prostate volume on prostate cancer detection. Eur Urol Suppl. 1:35–39. 2002. View Article : Google Scholar

28 

Campos-Fernandes JL, Bastien L, Nicolaiew N, Robert G, Terry S, Vacherot F, Salomon L, Allory Y, Vordos D, Hoznek A, et al: Prostate cancer detection rate in patients with repeated extended 21-sample needle biopsy. Eur Urol. 55:600–606. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Sajadi KP, Kim T, Terris MK, Brown JA and Lewis RW: High yield of saturation prostate biopsy for patients with previous negative biopsies and small prostates. Urology. 70:691–695. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Oderda M and Gontero P: High-grade prostatic intraepithelial neoplasia and atypical small acinar proliferation: Is repeat biopsy still necessary? BJU Int. 104:1554–1556. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Inahara M, Suzuki H, Nakamachi H, Kamiya N, Shimbo M, Komiya A, Ueda T, Ichikawa T, Akakura K and Ito H: Clinical evaluation of transrectal power doppler imaging in the detection of prostate cancer. Int Urol Nephrol. 36:175–180. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Chan TY and Epstein JI: Follow-up of atypical prostate needle biopsies suspicious for cancer. Urology. 53:351–355. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Heidenreich A, Aus G, Bolla M, Joniau S, Matveev VB, Schmid HP and Zattoni F: European Association of Urology: EAU guidelines on prostate cancer. Eur Urol. 53:68–80. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS and Redwine E: Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med. 317:909–916. 1987. View Article : Google Scholar : PubMed/NCBI

35 

Yaman O, Göğüş C, Tulunay O, Tokatli Z and Ozden E: Increased prostate-specific antigen in subclinical prostatitis: The role of aggressiveness and extension of inflammation. Urol Int. 71:160–164. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Schatteman PH, Hoekx L, Wyndaele JJ, Jeuris W and Van Marck E: Inflammation in prostate biopsies of men without prostatic malignancy or clinical prostatitis: Correlation with total serum PSA and PSA density. Eur Urol. 37:404–412. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Kandirali E, Boran C, Serin E, Semercioz A and Metin A: Association of extent and aggressiveness of inflammation with serum PSA levels and PSA density in asymptomatic patients. Urology. 70:743–747. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Terakawa T, Miyake H, Kanomata N, Kumano M, Takenaka A and Fujisawao M: Inverse association between histologic inflammation in needle biopsy specimens and prostate cancer in men with serum PSA of 10–50 ng/ml. Urology. 72:1194–1197. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kato T, Komiya A, Morii A, Iida H, Ito T and Fuse H: Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection. Oncol Lett 12: 1132-1138, 2016.
APA
Kato, T., Komiya, A., Morii, A., Iida, H., Ito, T., & Fuse, H. (2016). Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection. Oncology Letters, 12, 1132-1138. https://doi.org/10.3892/ol.2016.4693
MLA
Kato, T., Komiya, A., Morii, A., Iida, H., Ito, T., Fuse, H."Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection". Oncology Letters 12.2 (2016): 1132-1138.
Chicago
Kato, T., Komiya, A., Morii, A., Iida, H., Ito, T., Fuse, H."Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection". Oncology Letters 12, no. 2 (2016): 1132-1138. https://doi.org/10.3892/ol.2016.4693
Copy and paste a formatted citation
x
Spandidos Publications style
Kato T, Komiya A, Morii A, Iida H, Ito T and Fuse H: Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection. Oncol Lett 12: 1132-1138, 2016.
APA
Kato, T., Komiya, A., Morii, A., Iida, H., Ito, T., & Fuse, H. (2016). Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection. Oncology Letters, 12, 1132-1138. https://doi.org/10.3892/ol.2016.4693
MLA
Kato, T., Komiya, A., Morii, A., Iida, H., Ito, T., Fuse, H."Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection". Oncology Letters 12.2 (2016): 1132-1138.
Chicago
Kato, T., Komiya, A., Morii, A., Iida, H., Ito, T., Fuse, H."Analysis of repeated 24-core saturation prostate biopsy: Inverse association between asymptomatic histological inflammation and prostate cancer detection". Oncology Letters 12, no. 2 (2016): 1132-1138. https://doi.org/10.3892/ol.2016.4693
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