Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2016 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2016 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma

  • Authors:
    • Wei Lian
    • Ren Zhi Wang
    • Bing Xing
    • Yong Yao
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
    Copyright: © Lian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 893-896
    |
    Published online on: June 14, 2016
       https://doi.org/10.3892/ol.2016.4712
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the study was to examine the curative effects and proper radiotherapy plan of head γ-stereotactic radiotherapy (γ-SRT) for the treatment of functional pituitary macroadenoma. Clinical samples of 30 patients that underwent γ-SRT (radiotherapy group) and 26 patients that underwent pituitary adenoma resection via single nasal-sphenoidal approach (surgery group) were analyzed retrospectively and their curative effects were compared. The results showed that in the radiotherapy group, 12 cases accepted single fraction irradiation, with an average maximum diameter of tumor body of 1.8±0.6 cm, average volume of 0.6±0.4 cm3, average dose of the central point of 52.6±18.7 Gy, average dose of the peripheral point of 24.7±10.2 mGy, and isodose curve of 50-70%. The remaining 18 cases accepted multiple fraction irradiation, with an average irradiation of 3.7±1.6 times, maximum average diameter of tumor body of 4.3±1.8 cm, average volume of 4.8±2.7 cm3, average dose of the central point of 24.6±12.5 Gy, average dose of the peripheral point of 13.6±7.4 mGy, and isodose curve of 50-70%. Following treatment, the tumor volumes of patients in the radiotherapy group that received single and multiple irradiation were significantly reduced and the visual acuity and visual field were improved (p<0.05). The two groups were followed up for an average of 3.8 years, and the follow-up results showed that differences of the two groups on the tumor control, mortality and hypopituitarism rates were not statistically significant (p>0.05). In addition, the incidence of complications of the radiotherapy group was significantly decreased as compared to that of the surgery group (p<0.05). In conclusion, γ-SRT was safe and effective for the treatment of functional pituitary adenomas. Its curative effects were equivalent to that of the microscopic single nasal‑sphenoidal approach with fewer complications.
View Figures
View References

1 

Laws ER, Sheehan JP, Sheehan JM, Jagnathan J, Jane JA Jr and Oskouian R: Stereotactic radiosurgery for pituitary adenomas: a review of the literature. J Neurooncol. 69:257–272. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Huang BT, Lu JY, Lin PX, Chen JZ, Li DR and Chen CZ: Radiobiological modeling analysis of the optimal fraction scheme in patients with peripheral non-small cell lung cancer undergoing stereotactic body radiotherapy. Sci Rep. 5:180102015. View Article : Google Scholar : PubMed/NCBI

3 

Gopalan R, Schlesinger D, Vance ML, Laws E and Sheehan J: Long-term outcomes after Gamma Knife radiosurgery for patients with a nonfunctioning pituitary adenoma. Neurosurgery. 69:284–293. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Stafford SL, Pollock BE, Leavitt JA, Foote RL, Brown PD, Link MJ, Gorman DA and Schomberg PJ: A study on the radiation tolerance of the optic nerves and chiasm after stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 55:1177–1181. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Kopp C, Theodorou M, Poullos N, Astner ST, Geinitz H, Stalla GK, Meyer B, Molls M, Nieder C and Grosu AL: Fractionated stereotactic radiotherapy in the treatment of pituitary adenomas. Strahlenther Onkol. 189:932–937. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Senior BA, Ebert CS, Bednarski KK, Bassim MK, Younes M, Sigounas D and Ewend MG: Minimally invasive pituitary surgery. Laryngoscope. 118:1842–1855. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Leksell L: The stereotaxic method and radiosurgery of the brain. Acta Chir Scand. 102:316–319. 1951.PubMed/NCBI

8 

Barber SM, Teh BS and Baskin DS: Fractionated stereotactic radiotherapy for pituitary adenomas: single-center experience in 75 consecutive patients. Neurosurgery. 9:1–3. 2015. View Article : Google Scholar

9 

Weber DC, Momjian S, Pralong FP, Meyer P, Villemure JG and Pica A: Adjuvant or radical fractionated stereotactic radiotherapy for patients with pituitary functional and nonfunctional macroadenoma. Radiat Oncol. 6:1692011. View Article : Google Scholar : PubMed/NCBI

10 

Kajiwara K, Saito K, Yoshikawa K, Ideguchi M, Nomura S, Fujii M and Suzuki M: Stereotactic radiosurgery/radiotherapy for pituitary adenomas: A review of recent literature. Neurol Med Chir (Tokyo). 50:749–755. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Wilson PJ, Williams JR and Smee RI: Cushing's disease: a single centre's experience using the linear accelerator (LINAC) for stereotactic radiosurgery and fractionated stereotactic radiotherapy. J Clin Neurosci. 21:100–106. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Sheehan JM, Sheehan JP, Douds GL and Page RB: DDAVP use in patients undergoing transsphenoidal surgery for pituitary adenomas. Acta Neurochir (Wien). 148:287–291; discussion 291. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Shigematsu N, Kunieda E, Kawaguchi O, Takeda A, Ihara N, Yamashita S, Kubo A and Ito H: Naoyuki Shigematsu, Etsuo Kunieda: Indications of stereotactic irradiation for brain lesions. Acta Oncol. 39:597–603. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Hoban PW, Jones LC and Clark BG: Modeling late effects in hypofractionated stereotactic radiotherapy. Int J Radiat Oncol Biol Phys. 43:199–210. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Loeffler JS and Shih HA: Radiation therapy in the management of pituitary adenomas. J Clin Endocrinol Metab. 96:1992–2003. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Minniti G, Scaringi C, Poggi M, Jaffrain Rea ML, Trillò G, Esposito V, Bozzao A, Enrici MM, Toscano V and Enrici RM: Fractionated stereotactic radiotherapy for large and invasive non-functioning pituitary adenomas: long-term clinical outcomes and volumetric MRI assessment of tumor response. Eur J Endocrinol. 172:433–441. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Fernandez A, Brada M, Zabuliene L, Karavitaki N and Wass JA: Radiation-induced hypopituitarism. Endocr Relat Cancer. 16:733–772. 2009.doi: 10.1677/ERC-08-0231. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lian W, Wang RZ, Xing B and Yao Y: Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma. Oncol Lett 12: 893-896, 2016.
APA
Lian, W., Wang, R.Z., Xing, B., & Yao, Y. (2016). Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma. Oncology Letters, 12, 893-896. https://doi.org/10.3892/ol.2016.4712
MLA
Lian, W., Wang, R. Z., Xing, B., Yao, Y."Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma". Oncology Letters 12.2 (2016): 893-896.
Chicago
Lian, W., Wang, R. Z., Xing, B., Yao, Y."Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma". Oncology Letters 12, no. 2 (2016): 893-896. https://doi.org/10.3892/ol.2016.4712
Copy and paste a formatted citation
x
Spandidos Publications style
Lian W, Wang RZ, Xing B and Yao Y: Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma. Oncol Lett 12: 893-896, 2016.
APA
Lian, W., Wang, R.Z., Xing, B., & Yao, Y. (2016). Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma. Oncology Letters, 12, 893-896. https://doi.org/10.3892/ol.2016.4712
MLA
Lian, W., Wang, R. Z., Xing, B., Yao, Y."Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma". Oncology Letters 12.2 (2016): 893-896.
Chicago
Lian, W., Wang, R. Z., Xing, B., Yao, Y."Curative effects of head γ-SRT for the treatment of functional pituitary macroadenoma". Oncology Letters 12, no. 2 (2016): 893-896. https://doi.org/10.3892/ol.2016.4712
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team