|
1
|
Ingham PW and McMahon AP: Hedgehog
signaling in animal development: Paradigms and principles. Genes
Dev. 15:3059–3087. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Day TF and Yang Y: Wnt and hedgehog
signaling pathways in bone development. J Bone Joint Surg Am.
90(Suppl 1): S19–S24. 2008. View Article : Google Scholar
|
|
3
|
Ruel L, Rodriguez R, Gallet A,
Lavenant-Staccini L and Thérond PP: Stability and association of
Smoothened, Costal2 and Fused with Cubitus interruptus are
regulated by Hedgehog. Nat Cell Biol. 5:907–913. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Karlstrom RO, Tyurina OV, Kawakami A,
Nishioka N, Talbot WS, Sasaki H and Schier AF: Genetic analysis of
zebrafish gli1 and gli2 reveals divergent requirements for gli
genes in vertebrate development. Development. 130:1549–1564. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Dunaeva M, Michelson P, Kogerman P and
Toftgard R: Characterization of the physical interaction of Gli
proteins with SUFU proteins. J Biol Chem. 278:5116–5122. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Abidi A: Hedgehog signaling pathway: A
novel target for cancer therapy: Vismodegib, a promising
therapeutic option in treatment of basal cell carcinomas. Indian J
Pharmacol. 46:3–12. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Scott MP: Cancer: A twist in a hedgehog's
tale. Nature. 425:780–782. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
8
|
Johnson RL, Rothman AL, Xie J, Goodrich
LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH Jr
and Scott MP: Human homolog of patched, a candidate gene for the
basal cell nevus syndrome. Science. 272:1668–1671. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Cowan R, Hoban P, Kelsey A, Birch JM,
Gattamaneni R and Evans DG: The gene for the naevoid basal cell
carcinoma syndrome acts as a tumour-suppressor gene in
medulloblastoma. Br J Cancer. 76:141–145. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Taipale J, Chen JK, Cooper MK, Wang B,
Mann RK, Milenkovic L, Scott MP and Beachy PA: Effects of oncogenic
mutations in Smoothened and Patched can be reversed by cyclopamine.
Nature. 406:1005–1009. 2000. View
Article : Google Scholar : PubMed/NCBI
|
|
11
|
Incardona JP, Gaffield W, Kapur RP and
Roelink H: The teratogenic Veratrum alkaloid cyclopamine inhibits
sonic hedgehog signal transduction. Development. 125:3553–3562.
1998.PubMed/NCBI
|
|
12
|
Berman DM, Karhadkar SS, Hallahan AR,
Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale
J, Olson JM and Beachy PA: Medulloblastoma growth inhibition by
hedgehog pathway blockade. Science. 297:1559–1561. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Che J, Zhang FZ, Zhao CQ, Hu XD and Fan
SJ: Cyclopamine is a novel Hedgehog signaling inhibitor with
significant anti-proliferative, anti-invasive and anti-estrogenic
potency in human breast cancer cells. Oncol Lett. 5:1417–1421.
2013.PubMed/NCBI
|
|
14
|
Lewis MT, Ross S, Strickland PA, Sugnet
CW, Jimenez E, Hui C and Daniel CW: The Gli2 transcription factor
is required for normal mouse mammary gland development. Dev Biol.
238:133–144. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lewis MT: Hedgehog signaling in mouse
mammary gland development and neoplasia. J Mammary Gland Biol
Neoplasia. 6:53–66. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Xie J, Johnson RL, Zhang X, Bare JW,
Waldman FM, Cogen PH, Menon AG, Warren RS, Chen LC, Scott MP and
Epstein EH Jr: Mutations of the PATCHED gene in several types of
sporadic extracutaneous tumors. Cancer Res. 57:2369–2372.
1997.PubMed/NCBI
|
|
17
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Kayed H, Kleeff J, Osman T, Keleg S,
Büchler MW and Friess H: Hedgehog signaling in the normal and
diseased pancreas. Pancreas. 32:119–129. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhao L, Yu Y and Deng C: Protein and mRNA
expression of Shh, Smo and Gli1 and inhibition by cyclopamine in
hepatocytes of rats with chronic fluorosis. Toxicol Lett.
225:318–324. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Mistretta CM, Liu HX, Gaffield W and
MacCallum DK: Cyclopamine and jervine in embryonic rat tongue
cultures demonstrate a role for Shh signaling in taste papilla
development and patterning: Fungiform papillae double in number and
form in novel locations in dorsal lingual epithelium. Dev Biol.
254:1–18. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Chowdhury AK, Ghosh S, Rudin CM, Mukherjee
A, Basu A and Dhara S: Hedgehog signaling pathway is active in GBM
with GLI1 mRNA expression showing a single continuous distribution
rather than discrete high/low clusters. PLoS One. 10:e01163902015.
View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Ailles L and Siu LL: Targeting the
Hedgehog pathway in cancer: Can the spines be smoothened? Clin
Cancer Res. 17:2071–2073. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Theys J, Jutten B, Habets R, Paesmans K,
Groot AJ, Lambin P, Wouters BG, Lammering G and Vooijs M:
E-Cadherin loss associated with EMT promotes radioresistance in
human tumor cells. Radiother Oncol. 99:392–397. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Kessenbrock K, Wang CY and Werb Z: Matrix
metalloproteinases in stem cell regulation and cancer. Matrix Biol.
44–46:184–190. 2015. View Article : Google Scholar
|
|
25
|
Nwabo Kamdje AH, Seke Etet PF, Vecchio L,
Muller JM, Krampera M and Lukong KE: Signaling pathways in breast
cancer: therapeutic targeting of the microenvironment. Cell Signal.
26:2843–2856. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Qiao A, Gu F, Guo X, Zhang X and Fu L:
Breast cancer-associated fibroblasts: their roles in tumor
initiation, progression and clinical applications. Front Med.
10:33–40. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Hooper JE and Scott MP: Communicating with
Hedgehogs. Nat Rev Mol Cell Biol. 6:306–317. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Beachy PA, Karhadkar SS and Berman DM:
Tissue repair and stem cell renewal in carcinogenesis. Nature.
432:324–331. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Li Y, Maitah MY, Ahmad A, Kong D, Bao B
and Sarkar FH: Targeting the Hedgehog signaling pathway for cancer
therapy. Expert Opin Ther Targets. 16:49–66. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Di Magno L, Coni S, Di Marcotullio L and
Canettieri G: Digging a hole under Hedgehog: Downstream inhibition
as an emerging anticancer strategy. Biochim Biophys Acta.
1856:62–72. 2015.PubMed/NCBI
|
|
31
|
Jiang J and Hui CC: Hedgehog signaling in
development and cancer. Dev Cell. 15:801–812. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Hui M, Cazet A, Nair R, Watkins DN,
O'Toole SA and Swarbrick A: The Hedgehog signalling pathway in
breast development, carcinogenesis and cancer therapy. Breast
Cancer Res. 15:2032013. View
Article : Google Scholar : PubMed/NCBI
|
|
33
|
Kasper M, Regl G, Frischauf AM and Aberger
F: GLI transcription factors: Mediators of oncogenic Hedgehog
signalling. Eur J Cancer. 42:437–445. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Shahi MH, Afzal M, Sinha S, Eberhart CG,
Rey JA, Fan X and Castresana JS: Regulation of sonic hedgehog-GLI1
downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and
NKX2.2 and their epigenetic status in medulloblastoma and
astrocytoma. BMC Cancer. 10:6142010. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Regl G, Kasper M, Schnidar H, Eichberger
T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C,
Frischauf AM and Aberger F: Activation of the Bcl2 promoter in
response to Hedgehog/GLI signal transduction is predominantly
mediated by GLI2. Cancer Res. 64:7724–7731. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Joannes A, Grelet S, Duca L, Gilles C,
Kileztky C, Dalstein V, Birembaut P, Polette M and Nawrocki-Raby B:
Fhit regulates EMT targets through an EGFR/Src/ERK/Slug Signaling
axis in human bronchial cells. Mol Cancer Res. 12:775–783. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Bailey JM, Mohr AM and Hollingsworth MA:
Sonic hedgehog paracrine signaling regulates metastasis and
lymphangiogenesis in pancreatic cancer. Oncogene. 28:3513–3525.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Qi HW, Xin LY, Xu X, Ji XX and Fan LH:
Epithelial-to-mesenchymal transition markers to predict response of
Berberine in suppressing lung cancer invasion and metastasis. J
Transl Med. 12:222014. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Huang L, Wu RL and Xu AM:
Epithelial-mesenchymal transition in gastric cancer. Am J Transl
Res. 7:2141–2158. 2015.PubMed/NCBI
|
