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Article

Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial

  • Authors:
    • Janina Brucker
    • Christine Mayer
    • Gerhard Gebauer
    • Peter Mallmann
    • Antje Kristina Belau
    • Andreas Schneeweiss
    • Christof Sohn
    • Michael Eichbaum
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, University of Heidelberg Medical School, D‑69120 Heidelberg, Germany, Department of Gynecology and Gynecological Oncology, Marien Hospital Hamburg, D‑22087 Hamburg, Germany, Department of Gynecology and Obstetrics, University of Cologne Medical School, D‑50931 Köln, Germany, Department of Gynecology and Obstetrics, University of Greifswald Medical School, D‑17475 Greifswald, Germany, National Center for Tumor Diseases, University Hospital Heidelberg, D‑69120 Heidelberg, Germany, Department of Gynecology, St. Marien Hospital Frankfurt, D‑60318 Frankfurt, Germany
  • Pages: 1211-1215
    |
    Published online on: June 16, 2016
       https://doi.org/10.3892/ol.2016.4740
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Abstract

Patients with non-platinum-sensitive recurrent ovarian cancer have a poor prognosis. Non-pegylated liposomal doxorubicin (Myocet®) is a promising drug that may be able to improve treatment for such patients. In the current study, patients with recurrent ovarian cancer relapsing within 12 months after primary treatment received non‑pegylated liposomal doxorubicin at 75 mg/m2 d1q22 and 60 mg/m2 d1q22 after study dose modification, respectively. There were 29 patients enrolled in the trial, and 124 cycles of non‑pegylated liposomal doxorubicin were administered in total. All 29 patients were evaluable for toxicity. The clinical benefit rate (defined as the proportion of patients with either complete remission or partial remission, or with stable disease for >6 months) was 50%. The predominant non‑hematological toxicity was nausea and vomiting (18 patients, grade I/II), whilst no palmar plantar erythrodysesthesia was observed. In 3 patients, a grade III hematological toxicity occurred, and the treatment schedule was consequently modified to 60 mg/m2 d1q22. The findings suggest that non‑pegylated liposomal doxorubicin administered in a schedule of 60 mg/m2 d1q22 is well‑manageable and is associated with tolerable non‑hematological toxicities (predominantly nausea).
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Hennessy BT, Colemann RL and Markmann M: Ovarian Cancer. Lancet. 374:1371–1382. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Armstrong DK: Relapsed ovarian cancer: Challenges and management strategies for a chronic disease. Oncologist. 7(Suppl 5): 20–28. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Piccart MJ, Du Bois A, Gore ME, Neijt JP, Pecorelli S and Pujade-Lauraine E: A new standard of care for treatment of ovarian cancer. Eur J Cancer. 36:10–12. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Bookman MA: Standard treatment in advanced ovarian cancer in 2015 The state of the art. Int J Gynecol Cancer. 15:(Suppl 3). S212–S220. 2005. View Article : Google Scholar

6 

du Bois A, Herrstedt J, Hardy-Bessard AC, Müller HH, Harter P, Kristensen G, Joly F, Huober J, Avall-Lundqvist E, Weber B, et al: Phase III trial of carboplatin plus paclitaxel with or without gemcitabine in first-line treatment of epithelial ovarian cancer. J Clin Oncol. 28:4162–4169. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Naumann RW and Coleman RL: Management strategies for recurrent platinum-resistant ovarian cancer. Drugs. 71:1397–1412. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Pfisterer J and Ledermann JA: Management of platinum-sensitive recurrent ovarian cancer. Semin Oncol. 33(2 Suppl 6): S12–S16. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Cormio G, Loizzi V, Gissi F, Camporeale A, De Mitri P, Leone L, Putignano G and Selvaggi L: Long-term topotecan therapy in recurrent or persistent ovarian cancer. Eur J Gynaecol Oncol. 32:153–155. 2011.PubMed/NCBI

10 

Markman M: Pegylated liposomal doxorubicin: Appraisal of its current role in the management of epithelial ovarian cancer. Cancer Manag Res. 3:219–225. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Gordon AN, Granai CO, Rose PG, Hainsworth J, Lopez A, Weissman C, Rosales R and Sharpington T: Phase II study of liposomal doxorubicin in platinum-and paclitaxel-refractory epithelial ovarian cancer. J Clin Oncol. 18:3093–3100. 2000.PubMed/NCBI

12 

Muggia FM, Hainsworth JD, Jeffers S, Miller P, Groshen S, Tan M, Roman L, Uziely B, Muderspach L, Garcia A, et al: Phase II study of liposomal doxorubicin in refractory ovarian cancer: Antitumor activity ad toxicity modification by liposomal encapsulation. J Clin Oncol. 15:987–993. 1997.PubMed/NCBI

13 

Israel VP, Garcia AA, Roman L, Muderspach L, Burnett A, Jeffers S and Muggia FM: Phase II study of liposomal doxorubicin in advanced gynecological cancers. Gynecol Oncol. 78:143–147. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Campos SM, Penson RT, Mays AR, Berkowitz RS, Fuller AF, Goodman A, Matulonis UA, Muzikansky A and Seiden MV: The clinical utility of liposomal doxorubicin in recurrent ovarian cancer. Gynecol Oncol. 81:206–212. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Markman M, Kennedy A, Webster K, Peterson G, Kulp B and Belinson J: Phase 2 trial of liposomal doxorubicin (40 mg/m(2)) in platinum/paclitaxel-refractory ovarian and fallopian tube cancers and primary carcinoma of the peritoneum. Gynecol Oncol. 78:369–372. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Bernardi D, Errante D, Stefani M and Salvagno L: Non-pegylated liposomal doxorubicin in metastatic breast cancer patients: A valuable therapeutic option requiring caution. Breast. 19:549–550. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Lorusso D, Di Stefano A, Carone V, Fagotti A, Pisconti S and Scambia G: Pegylated liposomal doxorubicin-related palmar-plantar erythrodysesthesia (‘hand-foot’ syndrome). Ann Oncol. 18:1159–1164. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Miolo G, Baldo P, Bidoli E, Lombardi D, Scalone S, Sorio R and Veronesi A: Incidence of palmar-plantar erythrodysesthesia in pretreated and unpretreated patients receiving pegylated liposomal doxorubicin. Tumori. 95:687–690. 2009.PubMed/NCBI

19 

Meier W, Römisch M and Hepp H: The value of reoperation in the treatment of ovarian cancer. Geburtshilfe Frauenheilkd. 53:30–34. 1993. View Article : Google Scholar : PubMed/NCBI

20 

World Health Organization: WHO handbook for reporting results of cancer treatment. WHO offset publication. No. 48. World Health Organization; Geneva, Switzerland: 1979

21 

Cancer Therapy Evaluation Program. Common toxicity criteria for adverse events. Version 3.0. National Cancer Institute, National Institutes of Health; Bethseda, MD: 2006

22 

Food and Drug Administration: International Conference on Harmonisation. Good Clinical Practice Consolidated Guideline. 1997.https://www.gpo.gov/fdsys/pkg/FR-1997-05-09/pdf/97-12138.pdfAccessed. May 25–2016

23 

Heintz AP, Odicino F, Maisonneuve P, Beller U, Benedet JL, Creasman WT, Ngan HY, Sideri M and Pecorelli S: Carcinoma of the ovary. J Epidemiol Biostat. 6:107–138. 2001.PubMed/NCBI

24 

Bokemeyer C and Lipp HP: Allergic reaction. Compendium of Oncology Standards in Diagnosis and Therapy. Schmoll HJ, Höffken K and Possinger K: 4th. Springer-Verlag GmbH; Heidelberg: pp. pp1947–1952. 2006, (In German).

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Copy and paste a formatted citation
Spandidos Publications style
Brucker J, Mayer C, Gebauer G, Mallmann P, Belau AK, Schneeweiss A, Sohn C and Eichbaum M: Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial. Oncol Lett 12: 1211-1215, 2016.
APA
Brucker, J., Mayer, C., Gebauer, G., Mallmann, P., Belau, A.K., Schneeweiss, A. ... Eichbaum, M. (2016). Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial. Oncology Letters, 12, 1211-1215. https://doi.org/10.3892/ol.2016.4740
MLA
Brucker, J., Mayer, C., Gebauer, G., Mallmann, P., Belau, A. K., Schneeweiss, A., Sohn, C., Eichbaum, M."Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial". Oncology Letters 12.2 (2016): 1211-1215.
Chicago
Brucker, J., Mayer, C., Gebauer, G., Mallmann, P., Belau, A. K., Schneeweiss, A., Sohn, C., Eichbaum, M."Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial". Oncology Letters 12, no. 2 (2016): 1211-1215. https://doi.org/10.3892/ol.2016.4740
Copy and paste a formatted citation
x
Spandidos Publications style
Brucker J, Mayer C, Gebauer G, Mallmann P, Belau AK, Schneeweiss A, Sohn C and Eichbaum M: Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial. Oncol Lett 12: 1211-1215, 2016.
APA
Brucker, J., Mayer, C., Gebauer, G., Mallmann, P., Belau, A.K., Schneeweiss, A. ... Eichbaum, M. (2016). Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial. Oncology Letters, 12, 1211-1215. https://doi.org/10.3892/ol.2016.4740
MLA
Brucker, J., Mayer, C., Gebauer, G., Mallmann, P., Belau, A. K., Schneeweiss, A., Sohn, C., Eichbaum, M."Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial". Oncology Letters 12.2 (2016): 1211-1215.
Chicago
Brucker, J., Mayer, C., Gebauer, G., Mallmann, P., Belau, A. K., Schneeweiss, A., Sohn, C., Eichbaum, M."Non‑pegylated liposomal doxorubicin for patients with recurrent ovarian cancer: A multicentric phase II trial". Oncology Letters 12, no. 2 (2016): 1211-1215. https://doi.org/10.3892/ol.2016.4740
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