Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
August-2016 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2016 Volume 12 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of key target genes and pathways in laryngeal carcinoma

  • Authors:
    • Feng Liu
    • Jintao Du
    • Jun Liu
    • Bei Wen
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Otorhinolaryngology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1279-1286
    |
    Published online on: June 17, 2016
       https://doi.org/10.3892/ol.2016.4750
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of the present study was to screen the key genes associated with laryngeal carcinoma and to investigate the molecular mechanism of laryngeal carcinoma progression. The gene expression profile of GSE10935 [Gene Expression Omnibus (GEO) accession number], including 12 specimens from laryngeal papillomas and 12 specimens from normal laryngeal epithelia controls, was downloaded from the GEO database. Differentially expressed genes (DEGs) were screened in laryngeal papillomas compared with normal controls using Limma package in R language, followed by Gene Ontology (GO) enrichment analysis and pathway enrichment analysis. Furthermore, the protein‑protein interaction (PPI) network of DEGs was constructed using Cytoscape software and modules were analyzed using MCODE plugin from the PPI network. Furthermore, significant biological pathway regions (sub‑pathway) were identified by using iSubpathwayMiner analysis. A total of 67 DEGs were identified, including 27 up‑regulated genes and 40 down‑regulated genes and they were involved in different GO terms and pathways. PPI network analysis revealed that Ras association (RalGDS/AF‑6) domain family member 1 (RASSF1) was a hub protein. The sub‑pathway analysis identified 9 significantly enriched sub‑pathways, including glycolysis/gluconeogenesis and nitrogen metabolism. Genes such as phosphoglycerate kinase 1 (PGK1), carbonic anhydrase II (CA2), and carbonic anhydrase XII (CA12) whose node degrees were >10 were identified in the disease risk sub‑pathway. Genes in the sub-pathway, such as RASSF1, PGK1, CA2 and CA12 were presumed to serve critical roles in laryngeal carcinoma. The present study identified DEGs and their sub-pathways in the disease, which may serve as potential targets for treatment of laryngeal carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Licitra L, Bernier J, Grandi C, Locati L, Merlano M, Gatta G and Lefebvre JL: Cancer of the larynx. Crit Rev Oncol Hematol. 47:65–80. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Chen H, Zhou L, Dou T, Wan G, Tang H and Tian J: BMI1′S maintenance of the proliferative capacity of laryngeal cancer stem cells. Head Neck. 33:1115–1125. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Ferlito A, Rogers SN, Shaha AR, Bradley PJ and Rinaldo A: Quality of life in head and neck cancer. Acta Otolaryngol. 123:5–7. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Torrente MC, Rodrigo JP, Haigentz M Jr, Dikkers FG, Rinaldo A, Takes RP, Olofsson J and Ferlito A: Human papillomavirus infections in laryngeal cancer. Head Neck. 33:581–586. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Hobbs CG and Birchall MA: Human papillomavirus infection in the etiology of laryngeal carcinoma. Curr Opin Otolaryngol Head Neck Surg. 12:88–92. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Ma LJ, Li W, Zhang X, Huang DH, Zhang H, Xiao JY and Tian YQ: Differential gene expression profiling of laryngeal squamous cell carcinoma by laser capture microdissection and complementary DNA microarrays. Arch Med Res. 40:114–123. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Nakanishi H, Taccioli C, Palatini J, Fernandez-Cymering C, Cui R, Kim T, Volinia S and Croce C: Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway. Oncogene. 33:702–712. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Järvinen A, Autio R, Haapa-Paananen S, Wolf M, Saarela M, Grénman R, Leivo I, Kallioniemi O, Mäkitie AA and Monni O: Identification of target genes in laryngeal squamous cell carcinoma by high-resolution copy number and gene expression microarray analyses. Oncogene. 25:6997–7008. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Fountzilas E, Markou K, Vlachtsis K, Nikolaou A, Arapantoni-Dadioti P, Ntoula E, Tassopoulos G, Bobos M, Konstantinopoulos P, Fountzilas G and Spentzos D: Identification and validation of gene expression models that predict clinical outcome in patients with early-stage laryngeal cancer. Ann Oncol. 23:2146–2153. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Colombo J, Fachel AA, De Freitas Calmon M, Cury PM, Fukuyama EE, Tajara EH, Cordeiro JA, Verjovski-Almeida S, Reis EM and Rahal P: Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma. Oncol Rep. 21:649–663. 2009.PubMed/NCBI

11 

Oblak A and Jerala R: Toll-like receptor 4 activation in cancer progression and therapy. Clin Dev Immunol. 2011:609–579. 2011. View Article : Google Scholar

12 

DeVoti JA, Rosenthal DW, Wu R, Abramson AL, Steinberg BM and Bonagura VR: Immune dysregulation and tumor-associated gene changes in recurrent respiratory papillomatosis: A paired microarray analysis. Mol Med. 14:608–617. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Parker HS, Leek JT, Favorov AV, Considine M, Xia X, Chavan S, Chung CH and Fertig EJ: Preserving biological heterogeneity with a permuted surrogate variable analysis for genomics batch correction. Bioinformatics. 30:2757–2763. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Ihaka R and Gentleman R: R: A language for data analysis and graphics. J Comput Graph Stat. 5:299–314. 1996. View Article : Google Scholar

15 

Yuan K, Liang W and Zhang J: A comprehensive analysis of differentially expressed genes and pathways in abdominal aortic aneurysm. Mol Med Rep. 12:2707–2714. 2015.PubMed/NCBI

16 

Cui X and Churchill GA: Statistical tests for differential expression in cDNA microarray experiments. Genome Biol. 4:2102003. View Article : Google Scholar : PubMed/NCBI

17 

Diboun I, Wernisch L, Orengo CA and Koltzenburg M: Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma. BMC Genomics. 7:2522006. View Article : Google Scholar : PubMed/NCBI

18 

Bland JM and Altman DG: Multiple significance tests: The Bonferroni method. BMJ. 310:1701995. View Article : Google Scholar : PubMed/NCBI

19 

Belda-Ferre P, Alcaraz LD, Cabrera-Rubio R, et al: The oral metagenome in health and disease. ISME J. 6:46–56. 2012. View Article : Google Scholar : PubMed/NCBI

20 

da Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Köhler S, Bauer S, Horn D and Robinson PN: Walking the interactome for prioritization of candidate disease genes. Am J Hum Genet. 82:949–958. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Prasad Keshava TS, Goel R, Kandasamy K, Keerthikumar S, Kumar S, Mathivanan S, Telikicherla D, Raju R, Shafreen B, Venugopal A, et al: Human protein reference database-2009 update. Nucleic Acids Res. 37(Database Issue): D767–D772. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Stark C, Breitkreutz BJ, Chatr-Aryamontri A, Boucher L, Oughtred R, Livstone MS, Nixon J, Van Auken K, Wang X, Shi X, et al: The BioGRID interaction database: 2011 update. Nucleic Acids Res. 39(Database Issue): D698–D704. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Bandettini WP, Kellman P, Mancini C, Booker OJ, Vasu S, Leung SW, Wilson JR, Shanbhag SM, Chen MY and Arai AE: MultiContrast delayed enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: A clinical validation study. J Cardiovasc Magn Reson. 14:832012. View Article : Google Scholar : PubMed/NCBI

27 

Li C and Li MC: Package ‘iSubpathwayMiner’. 2013.

28 

Chen X, Xu J, Huang B, Li J, Wu X, Ma L, Jia X, Bian X, Tan F, Liu L, et al: A sub-pathway-based approach for identifying drug response principal network. Bioinformatics. 27:649–654. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Ayaz L, Görür A, Yaroğlu HY, Özcan C and Tamer L: Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: Potential early-detection markers for laryngeal squamous cell carcinoma. J Cancer Res Clin Oncol. 139:1499–1506. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J and Pfeifer GP: RASSF3 and NORE1: Identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene. 21:2713–2720. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Agathanggelou A, Cooper WN and Latif F: Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res. 65:3497–3508. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK and Califano JA: TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res. 16:857–866. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Sakurai D, Yamaguchi A, Tsuchiya N, Yamamoto K and Tokunaga K: Expression of ID family genes in the synovia from patients with rheumatoid arthritis. Biochem Biophys Res Commun. 284:436–442. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Coskunpinar E, Oltulu YM, Orhan KS, Tiryakioglu NO, Kanliada D and Akbas F: Identification of a differential expression signature associated with tumorigenesis and metastasis of laryngeal carcinoma. Gene. 534:183–188. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Wang X, Di K, Zhang X, Han HY, Wong YC, Leung SC and Ling MT: Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption. Oncogene. 27:4456–4466. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Bi X, Lin Q, Foo TW, Joshi S, You T, Shen HM, Ong CN, Cheah PY, Eu KW and Hew CL: Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: Mechanism of tumorigenesis. Mol Cell Proteomics. 5:1119–1130. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Gatenby RA and Gillies RJ: Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 4:891–899. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Valentini G, Maggi M and Pey AL: Protein stability, folding and misfolding in human PGK1 deficiency. Biomolecules. 3:1030–1052. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Ning QY, Wu JZ, Zang N, Liang J, Hu YL and Mo ZN: Key pathways involved in prostate cancer based on gene set enrichment analysis and meta analysis. Genet Mol Res. 10:3856–3887. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Vander Heiden MG: Targeting cancer metabolism: A therapeutic window opens. Nat Rev Drug Discov. 10:671–684. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Tennant DA, Durán RV and Gottlieb E: Targeting metabolic transformation for cancer therapy. Nat Rev Cancer. 10:267–277. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Lindskog S: Structure and mechanism of carbonic anhydrase. Pharmacol Ther. 74:1–20. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Dasgupta S, Tripathi PK, Qin H, Bhattacharya-Chatterjee M, Valentino J and Chatterjee SK: Identification of molecular targets for immunotherapy of patients with head and neck squamous cell carcinoma. Oral Oncol. 42:306–316. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Parkkila S, Rajaniemi H, Parkkila AK, Kivela J, Waheed A, Pastorekova S, Pastorek J and Sly WS: Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro. Proc Natl Acad Sci USA. 97:2220–2224. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Lascorz J, Hemminki K and Försti A: Systematic enrichment analysis of gene expression profiling studies identifies consensus pathways implicated in colorectal cancer development. J Carcinog. 10:72011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu F, Du J, Liu J and Wen B: Identification of key target genes and pathways in laryngeal carcinoma. Oncol Lett 12: 1279-1286, 2016.
APA
Liu, F., Du, J., Liu, J., & Wen, B. (2016). Identification of key target genes and pathways in laryngeal carcinoma. Oncology Letters, 12, 1279-1286. https://doi.org/10.3892/ol.2016.4750
MLA
Liu, F., Du, J., Liu, J., Wen, B."Identification of key target genes and pathways in laryngeal carcinoma". Oncology Letters 12.2 (2016): 1279-1286.
Chicago
Liu, F., Du, J., Liu, J., Wen, B."Identification of key target genes and pathways in laryngeal carcinoma". Oncology Letters 12, no. 2 (2016): 1279-1286. https://doi.org/10.3892/ol.2016.4750
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Du J, Liu J and Wen B: Identification of key target genes and pathways in laryngeal carcinoma. Oncol Lett 12: 1279-1286, 2016.
APA
Liu, F., Du, J., Liu, J., & Wen, B. (2016). Identification of key target genes and pathways in laryngeal carcinoma. Oncology Letters, 12, 1279-1286. https://doi.org/10.3892/ol.2016.4750
MLA
Liu, F., Du, J., Liu, J., Wen, B."Identification of key target genes and pathways in laryngeal carcinoma". Oncology Letters 12.2 (2016): 1279-1286.
Chicago
Liu, F., Du, J., Liu, J., Wen, B."Identification of key target genes and pathways in laryngeal carcinoma". Oncology Letters 12, no. 2 (2016): 1279-1286. https://doi.org/10.3892/ol.2016.4750
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team