|
1
|
Holland EC: Glioblastoma multiforme: The
terminator. Proc Natl Acad Sci USA. 97:6242–6244. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Adamson C, Kanu OO, Mehta AI, Di C, Lin N,
Mattox AK and Bigner DD: Glioblastoma multiforme: A review of where
we have been and where we are going. Expert Opin Investig Drugs.
18:1061–1083. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wang Y and Jiang T: Understanding high
grade glioma: Molecular mechanism, therapy and comprehensive
management. Cancer Lett. 331:139–146. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Westphal M and Lamszus K: The neurobiology
of gliomas: From cell biology tothe development of therapeutic
approaches. Nat Rev Neurosci. 12:495–508. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Rich JN: The role of transforming growth
factor-beta in primary brain tumors. Front Biosci. 8:e245–e260.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Platten M, Wick W and Weller M: Malignant
glioma biology: Role for TGF-beta in growth, motility,
angiogenesis, and immune escape. Microsc Res Tech. 52:401–410.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Ikushima H, Todo T, Ino Y, Takahashi M,
Miyazawa K and Miyazono K: Autocrine TGF-beta signaling maintains
tumorigenicity of glioma-initiating cells through Sry-related
HMG-box factors. Cell Stem Cell. 5:504–514. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Gregory PA, Bracken CP, Smith E, Bert AG,
Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, et al:
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates
establishment and maintenance of epithelial-mesenchymal transition.
Mol Biol Cell. 22:1686–1698. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Seoane J: Escaping from the TGFbeta
anti-proliferative control. Carcinogenesis. 27:2148–2156. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Massagué J: TGFbeta in cancer. Cell.
134:215–230. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Derynck R, Akhurst RJ and Balmain A:
TGF-beta signaling in tumor suppression and cancer progression. Nat
Genet. 29:117–129. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Siegel PM and Massagué J: Cytostatic and
apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev
Cancer. 3:807–821. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
13
|
Rahimi RA and Leof EB: TGF-beta signaling:
A tale of two responses. J Cell Biochem. 102:593–608. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Massagué J and Gomis RR: The logic of
TGFbeta signaling. FEBS Lett. 580:2811–2820. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kalluri R and Weinberg RA: The basics of
epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428.
2009. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Morel AP, Lièvre M, Thomas C, Hinkal G,
Ansieau S and Puisieux A: Generation of breast cancer stem cells
through epithelial-mesenchymal transition. PLoS One. 3:e28882008.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Taube JH, Herschkowitz JI, Komurov K, Zhou
AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, et
al: Core epithelial-to-mesenchymal transition interactome
gene-expression signature is associated with claudin-low and
metaplastic breast cancer subtypes. Proc Natl Acad Sci USA.
107:15449–15454. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Bryukhovetskiy A, Shevchenko V, Kovalev S,
Chekhonin V, Baklaushev V, Bryukhovetskiy I and Zhukova M: To the
novel paradigm of proteome-based cell therapy of tumors: Through
comparative proteome mapping of tumor stem cells and
tissue-specific stem cells of humans. Cell Transplant. 23(Suppl 1):
S151–S170. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Cox J and Mann M: MaxQuant enables high
peptide identification rates, individualized p.p.b.-range mass
accuracies and proteome-wide protein quantification. Nat
Biotechnol. 26:1367–1372. 2008. View
Article : Google Scholar : PubMed/NCBI
|
|
20
|
Louis DN: Molecular pathology of malignant
gliomas. Annu Rev Pathol. 1:97–117. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Louis DN, Ohgaki H, Wiestler OD, Cavenee
WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007
WHO classification of tumours of the central nervous system. Acta
Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Cancer Genome Atlas Research Network:
Comprehensive genomic characterization defines human glioblastoma
genes and core pathways. Nature. 455:1061–1068. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Platten M, Wick W and Weller M: Malignant
glioma biology: Role for TGF-beta in growth, motility,
angiogenesis, and immune escape. Microsc Res Tech. 52:401–410.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Sasaki A, Naganuma H, Satoh E, Nagasaka M,
Isoe S, Nakano S and Nukui H: Secretion of transforming growth
factor-beta 1 and -beta 2 by malignant glioma cells. Neurol Med
Chir (Tokyo). 35:423–430. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Wesolowska A, Kwiatkowska A, Slomnicki L,
Dembinski M, Master A, Sliwa M, Franciszkiewicz K, Chouaib S and
Kaminska B: Microglia-derived TGF-beta as an important regulator of
glioblastoma invasion - an inhibition of TGF-beta-dependent effects
by shRNA against human TGF-beta type II receptor. Oncogene.
27:918–930. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Hannon GJ and Beach D: P15INK4B is a
potential effector of TGF-beta-induced cell-cycle arrest. Nature.
371:257–261. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y
and Wang XF: Transforming growth factor beta induces the
cyclin-dependent kinase inhibitor p21 through a p53-independent
mechanism. Proc Natl Acad Sci USA. 92:5545–5549. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Eblen ST, Fautsch MP, Burnette RJ, Joshi P
and Leof EB: Cell cycle-dependent inhibition of p34cdc2 synthesis
by transforming growth factor beta 1 in cycling epithelial cells.
Cell Growth Differ. 5:109–116. 1994.PubMed/NCBI
|
|
29
|
Ignotz RA, Endo T and Massagué J:
Regulation of fibronectin and type I collagen mRNA levels by
transforming growth factor-beta. J Biol Chem. 262:6443–6446.
1987.PubMed/NCBI
|
|
30
|
Margadant C and Sonnenberg A:
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing.
EMBO Rep. 11:97–105. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Nakada M, Nakada S, Demuth T, Tran NL,
Hoelzinger DB and Berens ME: Molecular targets of glioma invasion.
Cell Mol Life Sci. 64:458–478. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Nakada M, Nambu E, Furuyama N, Yoshida Y,
Takino T, Hayashi Y, Sato H, Sai Y, Tsuji T, Miyamoto KI, et al:
Integrin α3 is overexpressed in glioma stem-like cells and promotes
invasion. Br J Cancer. 108:2516–2524. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Galanis E, Jaeckle KA, Maurer MJ, Reid JM,
Ames MM, Hardwick JS, Reilly JF, Loboda A, Nebozhyn M, Fantin VR,
et al: Phase II trial of vorinostat in recurrent glioblastoma
multiforme: A north central cancer treatment group study. J Clin
Oncol. 27:2052–2058. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Alvarez AA, Field M, Bushnev S, Longo MS
and Sugaya K: The effect of histone deacetylase inhibitors on
glioblastoma-derived stem cells. J Mol Neurosci. 55:7–20. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Pines G, Huang PH, Zwang Y, White FM and
Yarden Y: EGFRvIV: A previously uncharacterized oncogenic mutant
reveals a kinase autoinhibitory mechanism. Oncogene. 29:5850–5860.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Liang S, Shen G, Liu Q, Xu Y, Zhou L, Xiao
S, Xu Z, Gong F, You C and Wei Y: Isoform-specific expression and
characterization of 14-3-3 proteins in human glioma tissues
discovered by stable isotope labeling with amino acids in cell
culture-based proteomic analysis. Proteomics Clin Appl. 3:743–753.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Cao L, Cao W, Zhang W, Lin H, Yang X, Zhen
H, Cheng J, Dong W, Huo J and Zhang X: Identification of 14-3-3
protein isoforms in human astrocytoma by immunohistochemistry.
Neurosci Lett. 432:94–99. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Yang X, Cao W, Lin H, Zhang W, Lin W, Cao
L, Zhen H, Huo J and Zhang X: Isoform-specific expression of 14-3-3
proteins in human astrocytoma. J Neurol Sci. 276:54–59. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Lamouille S, Xu J and Derynck R: Molecular
mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell
Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Huang RY, Guilford P and Thiery JP: Early
events in cell adhesion and polarity during epithelial-mesenchymal
transition. J Cell Sci. 125:4417–4422. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Yilmaz M and Christofori G: EMT, the
cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev.
28:15–33. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Lehembre F, Yilmaz M, Wicki A, Schomber T,
Strittmatter K, Ziegler D, Kren A, Went P, Derksen PW, Berns A, et
al: NCAM-induced focal adhesion assembly: A functional switch upon
loss of E-cadherin. EMBO J. 27:2603–2615. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Hansen SM, Berezin V and Bock E: Signaling
mechanisms of neurite outgrowth induced by the cell adhesion
molecules NCAM and N-cadherin. Cell Mol Life Sci. 65:3809–3821.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Nisticò P, Bissell MJ and Radisky DC:
Epithelial-mesenchymal transition: General principles and
pathological relevance with special emphasis on the role of matrix
metalloproteinases. Cold Spring Harb Perspect Biol. 4:pii: a011908.
2012. View Article : Google Scholar
|
|
45
|
Derynck R and Zhang YE: Smad-dependent and
Smad-independent pathways in TGF-beta family signalling. Nature.
425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Moustakas A and Heldin CH: Non-Smad
TGF-beta signals. J Cell Sci. 118:3573–3584. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Xu J, Lamouille S and Derynck R:
TGF-beta-induced epithelial to mesenchymal transition. Cell Res.
19:156–172. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zavadil J and Böttinger EP: TGF-beta and
epithelial-to-mesenchymal transitions. Oncogene. 24:5764–5774.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Lamouille S and Derynck R: Emergence of
the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin
axis in transforming growth factor-β-induced epithelial-mesenchymal
transition. Cells Tissues Organs. 193:8–22. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Ridley AJ: Life at the leading edge. Cell.
145:1012–1022. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Ozdamar B, Bose R, Barrios-Rodiles M, Wang
HR, Zhang Y and Wrana JL: Regulation of the polarity protein Par6
by TGFbeta receptors controls epithelial cell plasticity. Science.
307:1603–1609. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Bhowmick NA, Ghiassi M, Bakin A, Aakre M,
Lundquist CA, Engel ME, Arteaga CL and Moses HL: Transforming
growth factor-beta1 mediates epithelial to mesenchymal
transdifferentiation through a RhoA-dependent mechanism. Mol Biol
Cell. 12:27–36. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Vardouli L, Moustakas A and Stournaras C:
LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton
reorganization induced by transforming growth factor-β. J Biol
Chem. 280:11448–11457. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Tavares AL, Mercado-Pimentel ME, Runyan RB
and Kitten GT: TGF beta-mediated RhoA expression is necessary for
epithelial-mesenchymal transition in the embryonic chick heart. Dev
Dyn. 235:1589–1598. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Sun X, Meyers EN, Lewandoski M and Martin
GR: Targeted disruption of Fgf8 causes failure of cell migration in
the gastrulating mouse embryo. Genes Dev. 13:1834–1846. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Lu Z, Ghosh S, Wang Z and Hunter T:
Downregulation of caveolin-1 function by EGF leads to the loss of
E-cadherin, increased transcriptional activity of beta-catenin, and
enhanced tumor cell invasion. Cancer Cell. 4:499–515. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei
Y, Abbruzzese JL, Hortobagyi GN and Hung MC: Epidermal growth
factor receptor cooperates with signal transducer and activator of
transcription 3 to induce epithelial-mesenchymal transition in
cancer cells via up-regulation of TWIST gene expression. Cancer
Res. 67:9066–9076. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Ahmed N, Maines-Bandiera S, Quinn MA,
Unger WG, Dedhar S and Auersperg N: Molecular pathways regulating
EGF-induced epithelio-mesenchymal transition in human ovarian
surface epithelium. Am J Physiol Cell Physiol. 290:C1532–C1542.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Moody SE, Perez D, Pan TC, Sarkisian CJ,
Portocarrero CP, Sterner CJ, Notorfrancesco KL, Cardiff RD and
Chodosh LA: The transcriptional repressor Snail promotes mammary
tumor recurrence. Cancer Cell. 8:197–209. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Knutson KL, Lu H, Stone B, Reiman JM,
Behrens MD, Prosperi CM, Gad EA, Smorlesi A and Disis ML:
Immunoediting of cancers may lead to epithelial to mesenchymal
transition. J Immunol. 177:1526–1533. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Yang L, Lin C and Liu ZR: P68 RNA helicase
mediates PDGF-induced epithelial mesenchymal transition by
displacing Axin from beta-catenin. Cell. 127:139–155. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Robbins JR, McGuire PG, Wehrle-Haller B
and Rogers SL: Diminished matrix metalloproteinase 2 (MMP-2) in
ectomesenchyme-derived tissues of the Patch mutant mouse:
Regulation of MMP-2 by PDGF and effects on mesenchymal cell
migration. Dev Biol. 212:255–263. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Wanami LS, Chen HY, Peiró S, de García
Herreros A and Bachelder RE: Vascular endothelial growth factor-A
stimulates Snail expression in breast tumor cells: Implications for
tumor progression. Exp Cell Res. 314:2448–2453. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Bruna A, Darken RS, Rojo F, Ocaña A,
Peñuelas S, Arias A, Paris R, Tortosa A, Mora J, Baselga J and
Seoane J: High TGFbeta-Smad activity confers poor prognosis in
glioma patients and promotes cell proliferation depending on the
methylation of the PDGF-B gene. Cancer Cell. 11:147–160. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Guo P, Hu B, Gu W, Xu L, Wang D, Huang HJ,
Cavenee WK and Cheng SY: Platelet-derived growth factor-B enhances
glioma angiogenesis by stimulating vascular endothelial growth
factor expression in tumor endothelia and by promoting pericyte
recruitment. Am J Pathol. 162:1083–1093. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Lamouille S, Connolly E, Smyth JW, Akhurst
RJ and Derynck R: TGF-β-induced activation of mTOR complex 2 drives
epithelial-mesenchymal transition and cell invasion. J Cell Sci.
125:1259–1273. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Kardassis D, Murphy C, Fotsis T, Moustakas
A and Stournaras C: Control of transforming growth factor beta
signal transduction by small GTPases. FEBS J. 276:2947–2965. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Katsuno Y, Lamouille S and Derynck R:
TGF-β signaling and epithelial-mesenchymal transition in cancer
progression. Curr Opin Oncol. 25:76–84. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Goldbrunner RH, Bernstein JJ and Tonn JC:
ECM-mediated glioma cell invasion. Microsc Res Tech. 43:250–257.
1998. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Verrecchia F and Mauviel A: Transforming
growth factor-beta signaling through the Smad pathway: Role in
extracellular matrix gene expression and regulation. J Invest
Dermatol. 118:211–215. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Schmid P, Itin P, Cherry G, Bi C and Cox
DA: Enhanced expression oftransforming growth factor-beta type I
and type II receptors in wound granulation tissue and hypertrophic
scar. Am J Pathol. 152:485–493. 1998.PubMed/NCBI
|
|
72
|
Akiyama Y, Jung S, Salhia B, Lee S,
Hubbard S, Taylor M, Mainprize T, Akaishi K, van Furth W and Rutka
JT: Hyaluronate receptors mediating glioma cell migration and
proliferation. J Neurooncol. 53:115–127. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Noël A, Gilles C, Bajou K, Devy L, Kebers
F, Lewalle JM, Maquoi E, Munaut C, Remacle A and Foidart JM:
Emerging roles for proteinasesin cancer. Invasion Metastasis.
17:221–239. 1997.PubMed/NCBI
|
|
74
|
Kleinman HK, Koblinski J, Lee S and
Engbring J: Role of basement membrane in tumor growth and
metastasis. Surg Oncol Clin N Am. 10:329–338. 2001.PubMed/NCBI
|
|
75
|
Bair EL, Chen ML, McDaniel K, Sekiguchi K,
Cress AE, Nagle RB and Bowden GT: Membrane type 1 matrix
metalloprotease cleaves laminin-10 and promotes prostate cancer
cell migration. Neoplasia. 7:380–389. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Ren B, Yee KO, Lawler J and Khosravi-Far
R: Regulation of tumor angiogenesis by thrombospondin-1. Biochim
Biophys Acta. 1765:178–188. 2006.PubMed/NCBI
|
|
77
|
Singh SK, Hawkins C, Clarke ID, Squire JA,
Bayani J, Hide T, Henkelman RM, Cusimano MD and Dirks PB:
Identification of human brain tumour initiating cells. Nature.
432:396–401. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Bao S, Wu Q, McLendon RE, Hao Y, Shi Q,
Hjelmeland AB, Dewhirst MW, Bigner DD and Rich JN: Glioma stem
cells promote radioresistance by preferential activation of the DNA
damage response. Nature. 444:756–760. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Schier AF and Talbot WS: Nodal signaling
and the zebrafish organizer. Int J Dev Biol. 45:289–297.
2001.PubMed/NCBI
|
|
80
|
Muñoz-Sanjuán I and Brivanlou AH: Neural
induction, the default model and embryonic stem cells. Nat Rev
Neurosci. 3:271–280. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
81
|
Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan
A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al: The
epithelial-mesenchymal transition generates cells with properties
of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Peñuelas S, Anido J, Prieto-Sánchez RM,
Folch G, Barba I, Cuartas I, García-Dorado D, Poca MA, Sahuquillo
J, Baselga J and Seoane J: TGF-beta increases glioma-initiating
cell self-renewal through the induction of LIF in human
glioblastoma. Cancer Cell. 15:315–327. 2009. View Article : Google Scholar : PubMed/NCBI
|
