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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2016 Volume 12 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma

  • Authors:
    • Dimitrios Mantas
    • Ioannis D. Kostakis
    • Nikolaos Machairas
    • Christos Markopoulos
  • View Affiliations / Copyright

    Affiliations: Breast Unit, Second Department of Propaedeutic Surgery, Athens Medical School, University of Athens, 11527 Athens, Greece
  • Pages: 1610-1614
    |
    Published online on: June 22, 2016
       https://doi.org/10.3892/ol.2016.4760
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Abstract

A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platelet counts from 53 patients with early breast cancer, who developed systemic metastases over a mean follow‑up period of 65 months, were analyzed and compared with those of a matching control group formed of 37 patients with the same characteristics, who remained recurrence‑free during the same time period. Patients who developed distant metastasis had a significantly higher mean platelet volume and lower neutrophil count than patients who did not present with distant metastasis. Furthermore, time to distant metastasis development was longer in patients with a lower mean platelet volume, whilst patients with a lower neutrophil count had a shorter systemic disease‑free time interval. However, receiver operating characteristic curve analysis demonstrated that these parameters provided moderate accuracy in predicting which patients may develop distant metastasis. No differences were detected between patient groups regarding additional parameters. Patients who developed systemic disease during a mean follow‑up period of 65 months were observed to have an increased mean platelet volume and decreased neutrophil count preoperatively. These results indicate that such parameters may be of prognostic value in patients with breast cancer. Studies with a larger number of patients are required to further investigate this hypothesis.
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Copy and paste a formatted citation
Spandidos Publications style
Mantas D, Kostakis ID, Machairas N and Markopoulos C: White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma. Oncol Lett 12: 1610-1614, 2016.
APA
Mantas, D., Kostakis, I.D., Machairas, N., & Markopoulos, C. (2016). White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma. Oncology Letters, 12, 1610-1614. https://doi.org/10.3892/ol.2016.4760
MLA
Mantas, D., Kostakis, I. D., Machairas, N., Markopoulos, C."White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma". Oncology Letters 12.2 (2016): 1610-1614.
Chicago
Mantas, D., Kostakis, I. D., Machairas, N., Markopoulos, C."White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma". Oncology Letters 12, no. 2 (2016): 1610-1614. https://doi.org/10.3892/ol.2016.4760
Copy and paste a formatted citation
x
Spandidos Publications style
Mantas D, Kostakis ID, Machairas N and Markopoulos C: White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma. Oncol Lett 12: 1610-1614, 2016.
APA
Mantas, D., Kostakis, I.D., Machairas, N., & Markopoulos, C. (2016). White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma. Oncology Letters, 12, 1610-1614. https://doi.org/10.3892/ol.2016.4760
MLA
Mantas, D., Kostakis, I. D., Machairas, N., Markopoulos, C."White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma". Oncology Letters 12.2 (2016): 1610-1614.
Chicago
Mantas, D., Kostakis, I. D., Machairas, N., Markopoulos, C."White blood cell and platelet indices as prognostic markers in patients with invasive ductal breast carcinoma". Oncology Letters 12, no. 2 (2016): 1610-1614. https://doi.org/10.3892/ol.2016.4760
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