Open Access

Correlation between histological grade and positron emission tomography parameters in cervical carcinoma

  • Authors:
    • Vanessa Mocciaro
    • Paolo Scollo
    • Alessandro Stefano
    • Stefania Gieri
    • Giorgio Russo
    • Giuseppe Scibilia
    • Sebastiano Cosentino
    • Gabriella Murè
    • Sara Baldari
    • Maria Gabriella Sabini
    • Filippo Fraggetta
    • Maria Carla Gilardi
    • Massimo Ippolito
  • View Affiliations

  • Published online on: June 23, 2016     https://doi.org/10.3892/ol.2016.4771
  • Pages: 1408-1414
  • Copyright: © Mocciaro et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to evaluate the changes in cervical cancer glucose metabolism for different levels of cellular differentiation. The metabolic activity was measured by standardized uptake value (SUV), SUV normalized to lean body mass, metabolic tumor volume and total lesion glycolysis using fluorine-18 fluorodeoxyglucose positron emission tomography (PET). A correlation study of these values could be used to facilitate therapeutic choice and to improve clinical practice and outcome. This study considered 32 patients with diagnosed cervical cancers, at different International Federation of Gynecology and Obstetrics stages. Glucose metabolism was assessed by PET examination, and histological specimens were examined to determine their initial grade of differentiation. A correlation study of these values was evaluated. Histological examination showed that all cases were of squamous cell carcinoma. Regarding the differentiation of the tumor, 19 well- to moderately-differentiated tumors and 13 poorly‑differentiated tumors were determined. Negative findings for correlations between metabolic parameters and initial grade of histological differentiation were found, and considering that histological grade has been shown to have no consistent prognostic value in cervical cancer treatment, PET imaging could play a significant role in cervical cancer prognosis.
View Figures
View References

Related Articles

Journal Cover

August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Mocciaro V, Scollo P, Stefano A, Gieri S, Russo G, Scibilia G, Cosentino S, Murè G, Baldari S, Sabini MG, Sabini MG, et al: Correlation between histological grade and positron emission tomography parameters in cervical carcinoma. Oncol Lett 12: 1408-1414, 2016
APA
Mocciaro, V., Scollo, P., Stefano, A., Gieri, S., Russo, G., Scibilia, G. ... Ippolito, M. (2016). Correlation between histological grade and positron emission tomography parameters in cervical carcinoma. Oncology Letters, 12, 1408-1414. https://doi.org/10.3892/ol.2016.4771
MLA
Mocciaro, V., Scollo, P., Stefano, A., Gieri, S., Russo, G., Scibilia, G., Cosentino, S., Murè, G., Baldari, S., Sabini, M. G., Fraggetta, F., Gilardi, M. C., Ippolito, M."Correlation between histological grade and positron emission tomography parameters in cervical carcinoma". Oncology Letters 12.2 (2016): 1408-1414.
Chicago
Mocciaro, V., Scollo, P., Stefano, A., Gieri, S., Russo, G., Scibilia, G., Cosentino, S., Murè, G., Baldari, S., Sabini, M. G., Fraggetta, F., Gilardi, M. C., Ippolito, M."Correlation between histological grade and positron emission tomography parameters in cervical carcinoma". Oncology Letters 12, no. 2 (2016): 1408-1414. https://doi.org/10.3892/ol.2016.4771