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Article Open Access

SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer

  • Authors:
    • Shu‑Hua Sun
    • Dan Liu
    • Yun‑Te Deng
    • Xiao‑Xue Zhang
    • Dong‑Yi Wan
    • Bi‑Xin Xi
    • Wei Huang
    • Qian Chen
    • Meng‑Chen Li
    • Ming‑Wei Wang
    • Fei Yang
    • Ping Shu
    • Ke‑Zhi Wu
    • Qing‑Lei Gao
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Hubei Cancer Hospital, Wuhan, Hubei 430023, P.R. China, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, P.R. China, Department of Pathology, Hubei Cancer Hospital, Wuhan, Hubei 430023, P.R. China, Department of Medical Records Room, Hubei Cancer Hospital, Wuhan, Hubei 430023, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1271-1278
    |
    Published online on: June 28, 2016
       https://doi.org/10.3892/ol.2016.4797
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Abstract

Epithelial-mesenchymal transition (EMT) plays a critical role in promoting tumor invasion and metastasis. However, the key cofactors that modulate the signal transduction to induce EMT have note been fully explored to date. The present study reports that sine oculis homeobox homolog 1 (SIX1) is able to promote EMT of cervical cancer by coordinating with transforming growth factor (TGF)β-SMAD signals. The expression of SIX1 was negatively correlated with the expression of the epithelial marker E-cadherin in two independent groups of cervical cancer specimens. SIX1 could promote the transition of mesenchymal phenotype in the presence of active TGFβ signals in vitro and in vivo. TGFβ-SMAD signals were required for the SIX1‑mediated promotion of EMT and metastatic capacity of cervical cancer cells. Together, SIX1 and TGFβ cooperated to induce more remarkable changes in the transition of phenotype than each of them alone, and coordinated to promote cell motility and tumor metastasis in cervical cancer. These results suggest that the coordination of SIX1 and TGFβ signals may be crucial in the EMT program, and that SIX1/TGFβ may be considered a valuable marker for evaluating the metastatic potential of cervical cancer cells, or a therapeutic target in the treatment of cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Sun SH, Liu D, Deng YT, Zhang XX, Wan DY, Xi BX, Huang W, Chen Q, Li MC, Wang MW, Wang MW, et al: SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer. Oncol Lett 12: 1271-1278, 2016.
APA
Sun, S., Liu, D., Deng, Y., Zhang, X., Wan, D., Xi, B. ... Gao, Q. (2016). SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer. Oncology Letters, 12, 1271-1278. https://doi.org/10.3892/ol.2016.4797
MLA
Sun, S., Liu, D., Deng, Y., Zhang, X., Wan, D., Xi, B., Huang, W., Chen, Q., Li, M., Wang, M., Yang, F., Shu, P., Wu, K., Gao, Q."SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer". Oncology Letters 12.2 (2016): 1271-1278.
Chicago
Sun, S., Liu, D., Deng, Y., Zhang, X., Wan, D., Xi, B., Huang, W., Chen, Q., Li, M., Wang, M., Yang, F., Shu, P., Wu, K., Gao, Q."SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer". Oncology Letters 12, no. 2 (2016): 1271-1278. https://doi.org/10.3892/ol.2016.4797
Copy and paste a formatted citation
x
Spandidos Publications style
Sun SH, Liu D, Deng YT, Zhang XX, Wan DY, Xi BX, Huang W, Chen Q, Li MC, Wang MW, Wang MW, et al: SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer. Oncol Lett 12: 1271-1278, 2016.
APA
Sun, S., Liu, D., Deng, Y., Zhang, X., Wan, D., Xi, B. ... Gao, Q. (2016). SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer. Oncology Letters, 12, 1271-1278. https://doi.org/10.3892/ol.2016.4797
MLA
Sun, S., Liu, D., Deng, Y., Zhang, X., Wan, D., Xi, B., Huang, W., Chen, Q., Li, M., Wang, M., Yang, F., Shu, P., Wu, K., Gao, Q."SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer". Oncology Letters 12.2 (2016): 1271-1278.
Chicago
Sun, S., Liu, D., Deng, Y., Zhang, X., Wan, D., Xi, B., Huang, W., Chen, Q., Li, M., Wang, M., Yang, F., Shu, P., Wu, K., Gao, Q."SIX1 coordinates with TGFβ signals to induce epithelial-mesenchymal transition in cervical cancer". Oncology Letters 12, no. 2 (2016): 1271-1278. https://doi.org/10.3892/ol.2016.4797
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