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Article

Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study

  • Authors:
    • Tobias Piegeler
    • Thomas Winder
    • Sabine Kern
    • Bernhard Pestalozzi
    • Paul Magnus Schneider
    • Beatrice Beck‑Schimmer
  • View Affiliations / Copyright

    Affiliations: Institute of Anesthesiology, University Hospital Zurich, 8091 Zurich, Switzerland, Department of Oncology, University Hospital Zurich, 8091 Zurich, Switzerland, Department of Visceral and Transplant Surgery, University Hospital Zurich, 8091 Zurich, Switzerland
  • Pages: 1513-1518
    |
    Published online on: June 30, 2016
       https://doi.org/10.3892/ol.2016.4809
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Abstract

Circulating tumor cells (CTCs) in the blood of cancer patients have been demonstrated to be of prognostic value regarding metastasis and survival. The CellSearch® system has been certified for the detection of CTCs and as a prognostic tool in patients with metastatic breast, colon and prostate cancer. Few studies have evaluated the detection of CTCs originating from esophagogastric or pancreatic cancer with the CellSearch® system. In the present small pilot study, a total of 16 patients with either esophagogastric (n=8) or pancreatic (n=8) adenocarcinomas at various disease stages were randomly screened and included. A total of 7.5 ml of blood was drawn from each patient and analyzed for CTCs using the CellSearch® device. CTCs could be detected in 1 out of 8 patients (12.5%) with esophagogastric and in 7 out of 8 patients (87.5%) with pancreatic cancer. The preliminary data obtained from this observational feasibility study suggested that the CellSearch® system may become a valuable tool for the detection of CTCs in patients with pancreatic adenocarcinoma, whereas the usefulness in patients with early‑stage esophagogastric adenocarcinoma may be limited. This study clearly points towards a requirement for larger studies focusing on patients with pancreatic adenocarcinoma at various disease stages and assessing CTCs, whereas patients with esophagogastric adenocarcinomas should be part of further pilot studies.
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Copy and paste a formatted citation
Spandidos Publications style
Piegeler T, Winder T, Kern S, Pestalozzi B, Schneider PM and Beck‑Schimmer B: Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study. Oncol Lett 12: 1513-1518, 2016.
APA
Piegeler, T., Winder, T., Kern, S., Pestalozzi, B., Schneider, P.M., & Beck‑Schimmer, B. (2016). Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study. Oncology Letters, 12, 1513-1518. https://doi.org/10.3892/ol.2016.4809
MLA
Piegeler, T., Winder, T., Kern, S., Pestalozzi, B., Schneider, P. M., Beck‑Schimmer, B."Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study". Oncology Letters 12.2 (2016): 1513-1518.
Chicago
Piegeler, T., Winder, T., Kern, S., Pestalozzi, B., Schneider, P. M., Beck‑Schimmer, B."Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study". Oncology Letters 12, no. 2 (2016): 1513-1518. https://doi.org/10.3892/ol.2016.4809
Copy and paste a formatted citation
x
Spandidos Publications style
Piegeler T, Winder T, Kern S, Pestalozzi B, Schneider PM and Beck‑Schimmer B: Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study. Oncol Lett 12: 1513-1518, 2016.
APA
Piegeler, T., Winder, T., Kern, S., Pestalozzi, B., Schneider, P.M., & Beck‑Schimmer, B. (2016). Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study. Oncology Letters, 12, 1513-1518. https://doi.org/10.3892/ol.2016.4809
MLA
Piegeler, T., Winder, T., Kern, S., Pestalozzi, B., Schneider, P. M., Beck‑Schimmer, B."Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study". Oncology Letters 12.2 (2016): 1513-1518.
Chicago
Piegeler, T., Winder, T., Kern, S., Pestalozzi, B., Schneider, P. M., Beck‑Schimmer, B."Detection of circulating tumor cells in patients with esophagogastric or pancreatic adenocarcinoma using the CellSearch® system: An observational feasibility study". Oncology Letters 12, no. 2 (2016): 1513-1518. https://doi.org/10.3892/ol.2016.4809
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