Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 12 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer

  • Authors:
    • Mai Kasahara
    • Makoto Nagahara
    • Tsuyoshi Nakagawa
    • Toshiaki Ishikawa
    • Takanobu Sato
    • Hiroyuki Uetake
    • Kenichi Sugihara
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113‑8510, Japan, Department of Translational Oncology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113‑8510, Japan
  • Pages: 1909-1914
    |
    Published online on: July 7, 2016
       https://doi.org/10.3892/ol.2016.4823
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Recently, kinesin motor proteins have been focused on as targets for cancer therapy. Kinesins are microtubule‑based motor proteins that mediate diverse functions within the cell, including the transport of vesicles, organelles, chromosomes and protein complexes, as well as the movement of microtubules. In the current study, the expression of kinesin family member 18A (KIF18A), a member of kinesin superfamily, was investigated in breast cancer using immunohistochemistry, and its effect on breast cancer prognosis was examined. KIF18A expression level was significantly associated with lymph node metastasis (P=0.047). In patients with high levels of KIF18A expression, survival was significantly poorer compared to patients with low levels of KIF18A expression (disease‑free survival, P=0.030). Multivariate analysis revealed that venous invasion (hazard ratio, 9.22; 95% confidence interval, 3.90‑23.66; P<0.001) and KIF18A expression (hazard ratio, 3.20; 95% confidence interval, 1.34‑6.09; P=0.010) were independent predictive factors for lymph node metastasis. KIF18A may be a useful predictive marker for lymph node metastasis in breast cancer, which could facilitate curative adjuvant treatment.
View Figures

Figure 1

Figure 2

View References

1 

Matsuda A, Matsuda T, Shibata A, Katanoda K, Sobue T and Nishimoto H: Japan Cancer Surveillance Research Group: Cancer incidence and incidence rates in Japan in 2008: A study of 25 population-based cancer registries for the monitoring of cancer incidence in Japan (MCIJ) project. Jpn J Clin Oncol. 44:388–396. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Katanoda K, Hori M, Matsuda T, Shibata A, Nishino Y, Hattori M, Soda M, Ioka A, Sobue T and Nishimoto H: An updated report on the trends in cancer incidence and mortality in Japan. Jpn J Clin Oncol. 45:390–401. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Peto R, Boreham J, Clarke M, Davies C and Beral V: UK and USA breast cancer deaths down 25% in year 2000 at ages 20–69 years. Lancet. 355:18222000. View Article : Google Scholar : PubMed/NCBI

4 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Harbeck N, Thomssen C and Gnant M: St. Gallen 2013: Brief preliminary summary of the consensus discussion. Breast Care (Basel). 8:102–109. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B and Senn HJ: Panel members: Strategies for subtypes-dealing with the diversity of breast cancer: Highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol. 22:1736–1747. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Falck AK, Bendahl PO, Chebil G, Olsson H, Fernö M and Rydén L: Biomarker expression and St Gallen molecular subtype classification in primary tumours, synchronous lymph node metastases and asynchronous relapses in primary breast cancer patients with 10 years' follow-up. Breast Cancer Res Treat. 140:93–104. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Marcus AI, Peters U, Thomas SL, Garrett S, Zelnak A, Kapoor TM and Giannakakou P: Mitotic kinesin inhibitors induce mitotic arrest and cell death in taxol-resistant and -sensitive cancer cells. J Biol Chem. 280:11569–11577. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Miglarese MR and Carlson RO: Development of new cancer therapeutic agents targeting mitosis. Expert Opin Investig Drugs. 15:1411–1425. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Huszar D, Theoclitou ME, Skolnik J and Herbst R: Kinesin motor proteins as targets for cancer therapy. Cancer Metastasis Rev. 28:197–208. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Kaestner P and Bastians H: Mitotic drug targets. J Cell Biochem. 111:258–265. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Sharp DJ, Rogers GC and Scholey JM: Microtubule motors in mitosis. Nature. 407:41–47. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Miki H, Setou M, Kaneshiro K and Hirokawa N: All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci USA. 98:7004–7011. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Kamal A and Goldstein LS: Principles of cargo attachment to cytoplasmic motor proteins. Curr Opin Cell Biol. 14:63–68. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Karcher RL, Deacon SW and Gelfand VI: Motor-cargo interactions: The key to transport specificity. Trends in Cell Biol. 12:21–27. 2002. View Article : Google Scholar

16 

Vale RD: The molecular motor toolbox for intracellular transport. Cell. 112:467–480. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Kline-Smith SL and Walczak CE: Mitotic spindle assembly and chromosome segregation: Refocusing on microtubule dynamics. Mol Cell. 15:317–327. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Mayr MI, Hümmer S, Bormann J, Grüner T, Adio S, Woehlke G and Mayer TU: The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr Biol. 17:488–498. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Stumpff J, von Dassow G, Wagenbach M, Asbury C and Wordeman L: The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev Cell. 14:252–262. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Gardner MK, Odde DJ and Bloom K: Kinesin-8 molecular motors: Putting the brakes on chromosome oscillations. Trends Cell Biol. 18:307–310. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Zhang C, Zhu C, Chen H, Li L, Guo L, Jiang W and Lu SH: Kif18A is involved in human breast carcinogenesis. Carcinogenesis. 31:1676–1684. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Nagahara M, Nishida N, Iwatsuki M, Ishimaru S, Mimori K, Tanaka F, Nakagawa T, Sato T, Sugihara K, Hoon DS and Mori M: Kinesin 18A expression: Clinical relevance to colorectal cancer progression. Int J Cancer. 129:2543–2552. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Rucksaken R, Khoontawad J, Roytrakul S, Pinlaor P, Hiraku Y, Wongkham C, Pairojkul C, Boonmars T and Pinlaor S: Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma. Cancer Biomark. 12:81–95. 2012.PubMed/NCBI

24 

Liao W, Huang G, Liao Y, Yang J, Chen Q, Xiao S, Jin J, He S and Wang C: High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma. Oncotarget. 5:10271–10279. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Mukai H, Aihara T, Yamamoto Y, Takahashi M, Toyama T, Sagara Y, Yamaguchi H, Akabane H, Tsurutani J, Hara F, et al: The Japanese Breast Cancer Society Clinical Practice Guideline for systemic treatment of breast cancer. Breast Cancer. 22:5–15. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, Dowsett M, Fitzgibbons PL, Hanna WM, Langer A, et al: American Society of Clinical Oncology; College of American Pathologists: American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol. 25:118–145. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Komoike Y, Inokuchi M, Itoh T, Kitamura K, Kutomi G, Sakai T, Jinno H, Wada N, Ohsumi S and Mukai H: Japanese Breast Cancer Society: Japan Breast Cancer Society clinical practice guideline for surgical treatment of breast cancer. Breast Cancer. 22:37–48. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Gradishar WJ, Anderson BO, Blair SL, Burstein HJ, Cyr A, Elias AD, Farrar WB, Forero A, Giordano SH, Goldstein LJ, et al: National Comprehensive Cancer Network Breast Cancer Panel: Breast cancer version 3.2014. J Natl Compr Canc Netw. 12:542–590. 2014.PubMed/NCBI

29 

Atalay C: New concepts in axillary management of breast cancer. World J Clin Oncol. 5:895–900. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Giuliano AE, Dale PS, Turner RR, Morton DL, Evans SW and Krasne DL: Improved axillary staging of breast cancer with sentinel lymphadenectomy. Ann Surg. 222:394–399; discussion 399–401. 1995. View Article : Google Scholar : PubMed/NCBI

31 

Ollila DW, Brennan MB and Giuliano AE: The role of intraoperative lymphatic mapping and sentinel lymphadenectomy in the management of patients with breast cancer. Adv Surg. 32:349–364. 1999.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kasahara M, Nagahara M, Nakagawa T, Ishikawa T, Sato T, Uetake H and Sugihara K: Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer. Oncol Lett 12: 1909-1914, 2016.
APA
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., & Sugihara, K. (2016). Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer. Oncology Letters, 12, 1909-1914. https://doi.org/10.3892/ol.2016.4823
MLA
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., Sugihara, K."Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer". Oncology Letters 12.3 (2016): 1909-1914.
Chicago
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., Sugihara, K."Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer". Oncology Letters 12, no. 3 (2016): 1909-1914. https://doi.org/10.3892/ol.2016.4823
Copy and paste a formatted citation
x
Spandidos Publications style
Kasahara M, Nagahara M, Nakagawa T, Ishikawa T, Sato T, Uetake H and Sugihara K: Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer. Oncol Lett 12: 1909-1914, 2016.
APA
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., & Sugihara, K. (2016). Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer. Oncology Letters, 12, 1909-1914. https://doi.org/10.3892/ol.2016.4823
MLA
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., Sugihara, K."Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer". Oncology Letters 12.3 (2016): 1909-1914.
Chicago
Kasahara, M., Nagahara, M., Nakagawa, T., Ishikawa, T., Sato, T., Uetake, H., Sugihara, K."Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer". Oncology Letters 12, no. 3 (2016): 1909-1914. https://doi.org/10.3892/ol.2016.4823
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team