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Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions

  • Authors:
    • Li Sun
    • Shubin Xu
    • Lei Liang
    • Liang Zhao
    • Lei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Bethune International Peace Hospital, Shijiazhuang, Hebei 050081, P.R. China, Department of Vascular Surgery, Bethune International Peace Hospital, Shijiazhuang, Hebei 050081, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1769-1772
    |
    Published online on: July 11, 2016
       https://doi.org/10.3892/ol.2016.4844
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Abstract

Cervical carcinoma is a multifactorial malignant tumor and diagnosis is therefore crucial. The aim of the present study was to examine the value of E6 oncoprotein, in human papillomavirus type 16 (HPV16), in the diagnosis of early stage cervical carcinoma and precancerous lesions. Receiver operating characteristic curve was used to analyze accuracy of diagnosis. A total of 124 patients infected with HPV16 were included in the study. The patients had an average age of 46.7±6.9 years and duration of disease of 10.5±3.4 months. To determine the expression level of HPV16 E6 the immunohistochemical Elivision method was performed. Proportion/horizon positive cells were used to count the cells, and pathologic diagnosis was employed for analysis of the results. The average follow-up time was 2.6±0.7 years. Sensitivity and specificity of diagnosing HPV16 E16 at 1 and 2 years, respectively, were calculated. The diagnostic rate of cervical carcinoma increased with time, and the positive expression of HPV16 E6 was also increased with the development of the disease. Differences among groups were statistically significant (P<0.05). Sensitivity, specificity and accuracy (AUC) of HPV16 E6 diagnosis improved with time, and the differences were statistically significant (P<0.05). Thus, HPV16 E6 oncoprotein can be used as an indicator with good sensitivity and specificity to diagnose early cervical carcinoma and precancerous lesions. The results therefore showed that accuracy increased with the development of the disease.
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1 

Mocarska A, Staroslawska E, Zelazowska-Cieślińska I, Łosicki M, Stasiewicz D, Kieszko D and Burdan F: Epidemiology and risk factors of the cervical squamous cell carcinoma. Pol Merkur Lekarski. 33:101–106. 2012.(In Polish). PubMed/NCBI

2 

Yung KW, Yung TT, Chung CY, Tong GT, Liu Y, Henderson J, Welbeck D and Oseni S: Principles of cancer staging. Asian Pac J Surg Oncol. 1:1–16. 2015.

3 

Chiappetta C, Lendaro E, Cacciotti J, Zaralli R, Puggioni C, Migliore G, Petrozza V, Rocca CD and Di Cristofano C: The 16, 18, and 45 HPV infection in high grade squamous cervical lesions in primary hr-HPV test screening program. Eur J Gynaecol Oncol. 36:722–725. 2015.PubMed/NCBI

4 

Smith JS, Lindsay L, Hoots B, Keys J, Franceschi S, Winer R and Clifford GM: Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer. 121:621–632. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Mzarico E, Gómez-Roig MD, Guirado L, Lorente N and Gonzalez-Bosquet E: Relationship between smoking, HPV infection, and risk of Cervical cancer. Eur J Gynaecol Oncol. 36:677–680. 2015.PubMed/NCBI

6 

Zacapala-Gómez AE, Del Moral-Hernández O, Villegas-Sepúlveda N, Hidalgo-Miranda A, Romero-Córdoba SL, Beltrán-Anaya FO, Leyva-Vázquez MA, Alarcón-Romero LC and Illades-Aguiar B: Changes in global gene expression profiles induced by HPV 16 E6 oncoprotein variants in cervical carcinoma C33-A cells. Virology. 488:187–195. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Poljak M, Kocjan BJ, Oštrbenk A and Seme K: Commercially available molecular tests for human papillomaviruses (HPV): 2015 update. J Clin Virol. 76(Suppl 1): S3–S13. 2015.PubMed/NCBI

8 

Zanier K, ould M'hamed ould Sidi A, Boulade-Ladame C, Rybin V, Chappelle A, Atkinson A, Kieffer B and Travé G: Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53. Structure. 20:604–617. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Zhang G, Sun L, Li Z, Si L, Song T, Huang C and Zhang W: HPV-16E6 can induce multiple site phosphorylation of p53. Oncol Rep. 21:371–377. 2009.PubMed/NCBI

10 

Bernard X, Robinson P, Nominé Y, Masson M, Charbonnier S, Ramirez-Ramos JR, Deryckere F, Travé G and Orfanoudakis G: Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain. PLoS One. 6:e259812011. View Article : Google Scholar : PubMed/NCBI

11 

Lee CJ, Suh EJ, Kang HT, Im JS, Um SJ, Park JS and Hwang ES: Induction of senescence-like state and suppression of telomerase activity through inhibition of HPV E6/E7 gene expression in cells immortalized by HPV16 DNA. Exp Cell Res. 277:173–182. 2002. View Article : Google Scholar : PubMed/NCBI

12 

D'Costa ZJ, Jolly C, Androphy EJ, Mercer A, Matthews CM and Hibma MH: Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. PLoS One. 7:e489542012. View Article : Google Scholar : PubMed/NCBI

13 

Dionne KR, Zhuang Y, Leser JS, Tyler KL and Clarke P: Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. J Virol. 87:3447–3460. 2013. View Article : Google Scholar : PubMed/NCBI

14 

White EA, Kramer RE, Tan MJ, Hayes SD, Harper JW and Howley PM: Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol. 86:13174–13186. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Niebler M, Qian X, Höfler D, Kogosov V, Kaewprag J, Kaufmann AM, Ly R, Böhmer G, Zawatzky R, Rösl F, et al: Post-translational control of IL-1β via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53. PLoS Pathog. 9:e10035362013. View Article : Google Scholar : PubMed/NCBI

16 

McCloskey R, Menges C, Friedman A, Patel D and McCance DJ: Human papillomavirus type 16 E6/E7 upregulation of nucleophosmin is important for proliferation and inhibition of differentiation. J Virol. 84:5131–5139. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun L, Xu S, Liang L, Zhao L and Zhang L: Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions. Oncol Lett 12: 1769-1772, 2016.
APA
Sun, L., Xu, S., Liang, L., Zhao, L., & Zhang, L. (2016). Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions. Oncology Letters, 12, 1769-1772. https://doi.org/10.3892/ol.2016.4844
MLA
Sun, L., Xu, S., Liang, L., Zhao, L., Zhang, L."Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions". Oncology Letters 12.3 (2016): 1769-1772.
Chicago
Sun, L., Xu, S., Liang, L., Zhao, L., Zhang, L."Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions". Oncology Letters 12, no. 3 (2016): 1769-1772. https://doi.org/10.3892/ol.2016.4844
Copy and paste a formatted citation
x
Spandidos Publications style
Sun L, Xu S, Liang L, Zhao L and Zhang L: Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions. Oncol Lett 12: 1769-1772, 2016.
APA
Sun, L., Xu, S., Liang, L., Zhao, L., & Zhang, L. (2016). Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions. Oncology Letters, 12, 1769-1772. https://doi.org/10.3892/ol.2016.4844
MLA
Sun, L., Xu, S., Liang, L., Zhao, L., Zhang, L."Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions". Oncology Letters 12.3 (2016): 1769-1772.
Chicago
Sun, L., Xu, S., Liang, L., Zhao, L., Zhang, L."Analysis of ROC: The value of HPV16 E6 protein in the diagnosis of early stage cervical carcinoma and precancerous lesions". Oncology Letters 12, no. 3 (2016): 1769-1772. https://doi.org/10.3892/ol.2016.4844
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