Open Access

Follow-up of IgD-κ multiple myeloma by monitoring free light chains and total heavy chain IgD: A case report

  • Authors:
    • Elena De Santis
    • Serena Masi
    • Iole Cordone
    • Francesco Pisani
    • Cecilia Zuppi
    • Fabrizio Mattei
    • Laura Conti
    • Giovanni Cigliana
  • View Affiliations

  • Published online on: July 15, 2016     https://doi.org/10.3892/ol.2016.4869
  • Pages: 1884-1888
  • Copyright: © De Santis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immunoglobulin (Ig)D‑κ multiple myeloma (MM) is a rare neoplastic disease characterized by an aggressive and rapidly progressing course, which constitutes only a very small proportion of all MM cases. In the present report, the clinical case of a 51‑year‑old Caucasian woman diagnosed with IgD‑κ MM is described. The patient underwent different chemotherapeutic treatments subsequently to a single autologous stem cell transplantation. Despite the inherent difficulty of monitoring IgD levels and performing serum immunofixation electrophoresis, the clinical outcome of the patient was almost uniquely monitored by measuring the levels of κ and λ free light chains (FLCs) and total heavy chain IgD. The data suggest the non‑invasive potential and usefulness of FLCs evaluation for early detection of stringent complete remission, follow‑up and early detection of disease relapse. In addition, this diagnostic procedure has successfully been employed for the therapeutic monitoring of the present patient, and may represent a very helpful, non‑invasive tool for the follow‑up of IgD myeloma patients without the requirement of serial bone marrow aspirate.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
De Santis E, Masi S, Cordone I, Pisani F, Zuppi C, Mattei F, Conti L and Cigliana G: Follow-up of IgD-κ multiple myeloma by monitoring free light chains and total heavy chain IgD: A case report. Oncol Lett 12: 1884-1888, 2016.
APA
De Santis, E., Masi, S., Cordone, I., Pisani, F., Zuppi, C., Mattei, F. ... Cigliana, G. (2016). Follow-up of IgD-κ multiple myeloma by monitoring free light chains and total heavy chain IgD: A case report. Oncology Letters, 12, 1884-1888. https://doi.org/10.3892/ol.2016.4869
MLA
De Santis, E., Masi, S., Cordone, I., Pisani, F., Zuppi, C., Mattei, F., Conti, L., Cigliana, G."Follow-up of IgD-κ multiple myeloma by monitoring free light chains and total heavy chain IgD: A case report". Oncology Letters 12.3 (2016): 1884-1888.
Chicago
De Santis, E., Masi, S., Cordone, I., Pisani, F., Zuppi, C., Mattei, F., Conti, L., Cigliana, G."Follow-up of IgD-κ multiple myeloma by monitoring free light chains and total heavy chain IgD: A case report". Oncology Letters 12, no. 3 (2016): 1884-1888. https://doi.org/10.3892/ol.2016.4869