Medullary metastasis of a malignant peripheral nerve sheath tumor: A case report

Hagi,Tomohito; Nakamura,Tomoki; Yokoji,Ayumu; Matsumine,Akihiko; Sudo,Akihiro

doi:10.3892/ol.2016.4872

September-2016 Volume 12 Issue 3

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September-2016 Volume 12 Issue 3

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Case Report

Medullary metastasis of a malignant peripheral nerve sheath tumor: A case report

Authors:
- Tomohito Hagi
- Tomoki Nakamura
- Ayumu Yokoji
- Akihiko Matsumine
- Akihiro Sudo
View Affiliations / Copyright

Affiliations: Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514‑8507, Japan, Department of Anesthesiology, Mie University Hospital, Tsu, Mie 514‑8507, Japan
Pages: 1906-1908
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Published online on: July 15, 2016

https://doi.org/10.3892/ol.2016.4872
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Abstract

The present study reports a case of medullary metastasis without lung metastasis that occurred as a result of a malignant peripheral nerve sheath tumor (MPNST). An 81‑year‑old woman presented with a MPNST in the left brachial plexus, arising from the cervical nerve root. The patient underwent carbon ion radiotherapy; however, tumor recurrence was identified in the left shoulder. Subsequently, the patient underwent wide excision. Three weeks subsequent to surgery, imbalance and dysarthria developed suddenly. Dysphagia emerged and left upper limb pain disappeared on the day after symptom development. Magnetic resonance imaging (MRI) revealed that this was due to metastasis to the medulla. Five days subsequent to the onset of dysarthria, the patient succumbed due to respiratory failure. To the best of our knowledge, no previous cases of medullary metastasis arising from a MPNST in the absence of lung metastasis have been reported. MRI is a useful examination tool for the identification of brain metastases; however, the high cost of MRI as a routine examination must be considered due to the rarity of brain metastases. Therefore, methods to detect brain metastasis warrant further investigation.

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1	Zhou W, Du X, Song F, Zheng H, Chen K, Zhang W and Yang J: Prognostic roles for fibroblast growth factor receptor family members in malignant peripheral nerve sheath tumor. Oncotarget. Mar 14–2016.(Epub ahead of print).
2	Rawal A, Yin Q, Roebuck M, Sinopidis C, Kalogrianitis S, Helliwell TR and Frostick S: Atypical and malignant peripheral nerve-sheath tumors of the brachial plexus: Report of three cases and review of the literature. Microsurgery. 26:80–86. 2006. View Article : Google Scholar : PubMed/NCBI
3	Valentin T, Le Cesne A, Ray-Coquard I, Italiano A, Decanter G, Bompas E, Isambert N, Thariat J, Linassier C and Bertucci F: Management and prognosis of malignant peripheral nerve sheath tumors: The experience of the French Sarcoma Group (GSF-GETO). Eur J Cancer. 56:77–84. 2016. View Article : Google Scholar : PubMed/NCBI
4	Espat NJ, Bilsky M, Lewis JJ, Leung D and Brennan MF: Soft tissue sarcoma brain metastases. Prevalence in a cohort of 3829 patients. Cancer. 94:2706–2711. 2002. View Article : Google Scholar : PubMed/NCBI
5	Nakamura T, Matsumine A, Matsubara T, Asanuma K, Niimi R, Uchida A and Sudo A: Retrospective analysis of metastatic sarcoma patients. Oncol Lett. 2:315–318. 2011.PubMed/NCBI
6	Ogose A, Morita T, Hotta T, Kobayashi H, Otsuka H, Hirata Y and Yoshida S: Brain metastases in musculoskeletal sarcomas. Jpn J Clin Oncol. 29:245–247. 1999. View Article : Google Scholar : PubMed/NCBI
7	Shweikeh F, Bukavina L, Saeed K, Sarkis R, Suneja A, Sweiss F and Drazin D: Brain metastasis in bone and soft tissue cancers: A review of incidence, interventions, and outcomes. Sarcoma. 2014:4751752014. View Article : Google Scholar : PubMed/NCBI
8	Lamm AF, Elaimy AL, Lamoreaux WT, Mackay AR, Fairbanks RK, Demakas JJ, Cooke BS and Lee CM: A review of the clinical outcomes for patients diagnosed with brainstem metastasis and treated with stereotactic radiosurgery. ISRN Surg. 2013:6528952013. View Article : Google Scholar : PubMed/NCBI
9	Lai-fung Li, Gilberto Ka-kit Leung, Ronnie Sin-lun Ho and Wai-man Lui: Recurrent natural killer cell lymphoma with central nervous system metastasis mimicking cerebellar infarction. World Neurosurg. 84:2074.e5–9. 2015. View Article : Google Scholar
10	Yoo TW, Park ES, Kwon do H and Kim CJ: Gamma knife radiosurgery for brainstem metastasis. J Korean Neurosurg Soc. 50:299–303. 2011. View Article : Google Scholar : PubMed/NCBI
11	Lang EF and Slater J: Metastatic brain tumors: results of surgical and non-surgical treatment. Surg Clin North Am. 44:865–872. 1964.PubMed/NCBI
12	Markesbery WR, Brooks WH, Gupta GD and Young AB: Treatment for patients with cerebral metastases. Arch Neurol. 35:754–756. 1978. View Article : Google Scholar : PubMed/NCBI
13	Smalley SR, Laws ER Jr, O'Fallon JR, Shaw EG and Schray MF: Resection for solitary brain metastasis. Role of adjuvant radiation and prognostic variables in 229 patients. J Neurosurg. 77:531–540. 1992. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Medullary metastasis of a malignant peripheral nerve sheath tumor: A case report

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