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Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients

  • Authors:
    • Ohad Hilly
    • Nir Pillar
    • Sagit Stern
    • Yulia Strenov
    • Gideon Bachar
    • Noam Shomron
    • Thomas Shpitzer
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Rabin Medical Center, Petah Tikva 49100, Israel, Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel, Department of Pathology, Rabin Medical Center, Petah Tikva 49100, Israel
    Copyright: © Hilly et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1729-1736
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    Published online on: July 20, 2016
       https://doi.org/10.3892/ol.2016.4892
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Abstract

Oral cavity squamous cell carcinoma may be more aggressive at presentation and recurrence in young patients compared with older patients. Dysregulation of microRNAs (miRNAs or miRs) has been associated with the development and prognosis of oral cavity cancer. The present study investigated miRNA expression in carcinoma of the oral tongue in young patients. miRNA expression profiles were evaluated in formalin‑fixed, paraffin‑embedded samples of tumor and normal mucosa from 12 patients aged <30 years old with squamous cell carcinoma of the tongue. The levels of let-7f-5p, miR-30b-5p and let-7e-5p were upregulated in tumors (P<0.05). The expression of let‑7f‑5p was upregulated in non‑aggressive tumors, while the expression of let‑7e‑5p was upregulated in aggressive tumors, compared with the corresponding normal tissue. Aggressive tumors had higher levels of let‑7c, miR‑130a‑3p, miR‑361‑5p, miR‑99a‑5p, miR‑29c‑3p and let-7d-5p than non‑aggressive tumors (P<0.05). The findings remained significant for let‑7c upon false‑discovery rate correction. An excellent correlation was noticed on validation of NanoString counts by quantitative polymerase chain reaction. The comparison with published findings in adults demonstrated a unique miRNA signature in young patients with aggressive disease. Aggressive oral cavity cancer in patients <30 years old is associated with a distinctive expression pattern of the let‑7 family. Larger studies including direct comparison with older patients are warranted.
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Hilly O, Pillar N, Stern S, Strenov Y, Bachar G, Shomron N and Shpitzer T: Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients. Oncol Lett 12: 1729-1736, 2016.
APA
Hilly, O., Pillar, N., Stern, S., Strenov, Y., Bachar, G., Shomron, N., & Shpitzer, T. (2016). Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients. Oncology Letters, 12, 1729-1736. https://doi.org/10.3892/ol.2016.4892
MLA
Hilly, O., Pillar, N., Stern, S., Strenov, Y., Bachar, G., Shomron, N., Shpitzer, T."Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients". Oncology Letters 12.3 (2016): 1729-1736.
Chicago
Hilly, O., Pillar, N., Stern, S., Strenov, Y., Bachar, G., Shomron, N., Shpitzer, T."Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients". Oncology Letters 12, no. 3 (2016): 1729-1736. https://doi.org/10.3892/ol.2016.4892
Copy and paste a formatted citation
x
Spandidos Publications style
Hilly O, Pillar N, Stern S, Strenov Y, Bachar G, Shomron N and Shpitzer T: Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients. Oncol Lett 12: 1729-1736, 2016.
APA
Hilly, O., Pillar, N., Stern, S., Strenov, Y., Bachar, G., Shomron, N., & Shpitzer, T. (2016). Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients. Oncology Letters, 12, 1729-1736. https://doi.org/10.3892/ol.2016.4892
MLA
Hilly, O., Pillar, N., Stern, S., Strenov, Y., Bachar, G., Shomron, N., Shpitzer, T."Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients". Oncology Letters 12.3 (2016): 1729-1736.
Chicago
Hilly, O., Pillar, N., Stern, S., Strenov, Y., Bachar, G., Shomron, N., Shpitzer, T."Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients". Oncology Letters 12, no. 3 (2016): 1729-1736. https://doi.org/10.3892/ol.2016.4892
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