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Article Open Access

Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells

  • Authors:
    • Shuhua Wang
    • Qingqing Tian
    • Fang An
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China, Graduate Faculty, Hebei North University, Zhangjiakou, Hebei 075000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1705-1710
    |
    Published online on: July 21, 2016
       https://doi.org/10.3892/ol.2016.4898
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Abstract

Dried flowers of Trollius chinensis have long been used as an important traditional Chinese medicine. Previous studies have demonstrated the ability of T. chinensis flavonoids to reduce the proliferation of human breast cancer MCF-7 cells. The present study further investigated the influence of T. chinensis flavonoids on the growth and proliferation of MCF‑7 cells and observed clear inhibitory effects within the concentration range of 0.0991‑1.5856 mg/ml. Apoptosis was triggered by T. chinensis flavonoids treatment that was evaluated by differential interference contrast software, the Hoechst 33258 method, scanning electron microscopy, hematoxylin/eosin staining and laser confocal light microscopy. Cells treated with T. chinensis flavonoids selectively reduced bcl‑2 and NF‑κB expression and increased the expression of caspase-9 and caspase-3 indicating that the inhibition of cellular proliferation occurred through activation of a mitochondrial pathway. Taken together, the results confirmed the ability of T. chinensis flavonoids to inhibit cell proliferation.
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1 

Li SP and Jiao W: Exercise and Prevention of breast cancer. Wuhan Tiyuxue Yuan Xue Bao. 48:71–77. 2014.(In Chinese).

2 

Lin FQ, Feng SQ, Li WL, et al: Antiviral ingredients research of Trollius chinensis. Zhejiang Daxue Xue Bao. 31:4122004.(In Chinese).

3 

Li YL, Ye SM, Wang LY, et al: The isolation and bioactivity of proglobeflowery acid in Trollius macropetalus. Jinan Daxue Xue Bao. 23:124–126. 2002.(In Chinese).

4 

Li LQ: The geographical distribution of Helleboroideae plants of buttercup family. Zhi Wu Fen Lei Xue Bao. 33:535–537. 1995.(In Chinese).

5 

Yang GD, Rao N, Wang SH, et al: The research on antioxidant of orientin and vitexin in Trollius chinensis. Shizhen Guo Yi Guo Yao. 22:2172–3. 2011.(In Chinese).

6 

Yan J, Hu H, An F, et al: The research on antioxidant of trollius flavonoids. Shizhen Guo Yi Guo Yao. 22:386–7. 2010.(In Chinese).

7 

Fu XC, Li SP, Wang MW, et al: The relaxant effect and the mechanism of orientin on aorta smooth muscle. Nanfang Yi Ke Daxue Xue Bao. 27:1173–5. 2007.(In Chinese).

8 

Fu XC, Li SP, Wang XG, et al: The research on antithrombotic effect of orientin. Zhong Guo Yao Fang. 17:1292–3. 2006.(In Chinese).

9 

Fu XC, Li SP, Qiu YF, et al: The research on Anti-anoxia of orientin on mice of anoxia model. Zhong Guo Yao Fang. 17:654–35. 2006.(In Chinese).

10 

Liu P, Chen GH, Deng SH, Liu YL and Tong JM: The anti-microbial activity research of trollius flavonoids. Zhonguo Shi Yan Fang Ji Xue Zazhi. 19:207–210. 2013.(In Chinese).

11 

Yan J: The antioxidant effects research of trollius flavonoids. Shizhen Guo Yi Guo Yao. 21:386–387. 2010.(In Chinese).

12 

Sun L and Cheng JZ: The effect of trollius flavonoids on K562, Hela, EC-109 and NCI-H446 cells proliferation. Zhong Guo Laonian Xue Zazhi. 44:981–983. 2009.(In Chinese).

13 

Sun L and Luo Q: The effect of trollius flavonoids on proliferation and apoptosis of A549 cells. Zhong Guo Laonian Xue Zazhi. 31:82–83. 2011.(In Chinese).

14 

Sun Li: The effect of trollius flavonoids on breast cancer cells. Zhong Guo Laonian Xue Zazhi. 29:1098–9. 2009.(In Chinese).

15 

Yan J, Qu CH, Tian JM, An F and Wang SH: The study on purification of trollius flavonoids. Hebei Bei Fang Xue Yuan Xue Bao. 26:20–2. 2009.

16 

Lu Y: The activity study of fermentative soy isoflavone. Dong Bei Nong Ye Da Xue. 2005.(In Chinese).

17 

Ji CY: The research on effect of huaier granule on breast cancer MCF-7 (ER+) and MDA-MB-231 (ER-) cells. Nanhua Daxue. 2013.(In Chinese).

18 

Wang H: The study on apoptosis of breast cancerMDA-MB-231 cells induced by genistein. Zhong Hua Ruxian Bing Zazhi. 7:322–328. 2013.(In Chinese).

19 

Li HZ, Zheng Y, Lin P, Dou CM, Dong JY and Wang TW: The effect of herceptin on cell cycle and apoptosis of breast cancer cells. Ji Chuyi Xue Yu Lin Chuang. 27:1251–1256. 2007.(In Chinese).

20 

Li XL: The inhibition effect of soy isoflavone and vinorelbine on lung adenocarcinoma A 549 cells. Yan Bian Daxue. 2006.(In Chinese).

21 

Jimingjie. The research on cancer cell apoptosis induced by ar-curcumene. Shandong Daxue. (In Chinese).

22 

Biswas DK, Martin KJ, McAlister C, Cruz AP, Graner E, Dai SC and Pardee AB: Apoptosis caused by chemotherapeutic inhibition of nuclear factor-kappaB activation. Cancer Res. 63:290–295. 2003.PubMed/NCBI

23 

Lee CY, Chien YS, Chiu TH, Huang WW, Lu CC, Chiang JH and Yang JS: Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway. Oncol Rep. 28:1883–1888. 2012.PubMed/NCBI

24 

Chen DY, Zhai ZH and Shu HB: The regulating mechanism of NF-κB activation. Ke Xue Tong Bao. 48:1893–911. 2003.(In Chinese).

25 

Orrenius S: Reactive oxygen species in mitochondrial-mediated cell death. Drug Meteb Rev. 39:443–455. 2007. View Article : Google Scholar

26 

Blanc C, Deveraux QL, Krajewski S, Jänicke RU, Porter AG, Reed JC, Jaggi R and Marti A: Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. Cancer Res. 60:4386–4390. 2000.PubMed/NCBI

27 

Reesink-Peters N, Hougardy BM, Hoor KA, van den Heuvel FA, Ten Hoor KA, Hollema H, Boezen HM, de Vries EG, de Jong S and van der Zee AG: Death recePtors and ligands in cervical carcinogenesis: An immunohistochemical study. Gynecol Oncol. 96:705–713. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Asker C, Wiman KG and Selivanova G: P53-induced apoptosis as a safeguard against cancer. Biochem Biophys Res Commun. 265:1–6. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Sheikh MS and Furnace AJ Jr: Role of p53 family members in apoptosis. J Cell Phvsiol. 182:171–181. 2000. View Article : Google Scholar

30 

Zhangping. The research on cancer cell apoptosis induced by flavonoids from seed residues and the corresponding mechanism. Hua Dong Shi Fan Da Xue. 2004.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Wang S, Tian Q and An F: Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells. Oncol Lett 12: 1705-1710, 2016.
APA
Wang, S., Tian, Q., & An, F. (2016). Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells. Oncology Letters, 12, 1705-1710. https://doi.org/10.3892/ol.2016.4898
MLA
Wang, S., Tian, Q., An, F."Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells". Oncology Letters 12.3 (2016): 1705-1710.
Chicago
Wang, S., Tian, Q., An, F."Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells". Oncology Letters 12, no. 3 (2016): 1705-1710. https://doi.org/10.3892/ol.2016.4898
Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Tian Q and An F: Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells. Oncol Lett 12: 1705-1710, 2016.
APA
Wang, S., Tian, Q., & An, F. (2016). Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells. Oncology Letters, 12, 1705-1710. https://doi.org/10.3892/ol.2016.4898
MLA
Wang, S., Tian, Q., An, F."Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells". Oncology Letters 12.3 (2016): 1705-1710.
Chicago
Wang, S., Tian, Q., An, F."Growth inhibition and apoptotic effects of total flavonoids from Trollius chinensis on human breast cancer MCF-7 cells". Oncology Letters 12, no. 3 (2016): 1705-1710. https://doi.org/10.3892/ol.2016.4898
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