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Article

IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling

  • Authors:
    • Nan Zhou
    • Fuding Lu
    • Cheng Liu
    • Kewei Xu
    • Jian Huang
    • Dexin Yu
    • Liangkuan Bi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Urology, Sun Yat‑sen Memorial Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 1915-1920
    |
    Published online on: July 21, 2016
       https://doi.org/10.3892/ol.2016.4900
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Abstract

The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated with the metastasis of RCC; however, the underlying molecular mechanism has not been determined yet. The present study revealed that interleukin (IL)‑8 was highly expressed in metastatic RCC. IL-8 could induce the EMT of an RCC cell line by enhancing N‑cadherin expression and decreasing E‑cadherin expression. Furthermore, IL‑8 could induce AKT phosphorylation, and the phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor LY294002 could inhibit the EMT of RCC cells that was induced by IL‑8. Therefore, these results suggest that IL‑8 is able to promote the EMT of RCC through the activation of the AKT signal transduction pathway, and this may provide a possible molecular mechanism for RCC metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou N, Lu F, Liu C, Xu K, Huang J, Yu D and Bi L: IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling. Oncol Lett 12: 1915-1920, 2016.
APA
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., & Bi, L. (2016). IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling. Oncology Letters, 12, 1915-1920. https://doi.org/10.3892/ol.2016.4900
MLA
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., Bi, L."IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling". Oncology Letters 12.3 (2016): 1915-1920.
Chicago
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., Bi, L."IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling". Oncology Letters 12, no. 3 (2016): 1915-1920. https://doi.org/10.3892/ol.2016.4900
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou N, Lu F, Liu C, Xu K, Huang J, Yu D and Bi L: IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling. Oncol Lett 12: 1915-1920, 2016.
APA
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., & Bi, L. (2016). IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling. Oncology Letters, 12, 1915-1920. https://doi.org/10.3892/ol.2016.4900
MLA
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., Bi, L."IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling". Oncology Letters 12.3 (2016): 1915-1920.
Chicago
Zhou, N., Lu, F., Liu, C., Xu, K., Huang, J., Yu, D., Bi, L."IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling". Oncology Letters 12, no. 3 (2016): 1915-1920. https://doi.org/10.3892/ol.2016.4900
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