Open Access

Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer

  • Authors:
    • Jing Zhang
    • Kundong Zhang
    • Lisheng Zhou
    • Weidong Wu
    • Tao Jiang
    • Jun Cao
    • Kejian Huang
    • Zhengjun Qiu
    • Chen Huang
  • View Affiliations

  • Published online on: July 28, 2016     https://doi.org/10.3892/ol.2016.4915
  • Pages: 2381-2388
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the expression and functions of Forkhead box protein M1 (FoxM1), Caveolin-1 (Cav-1) and E-cadherin in colorectal cancer (CRC), and to determine the correlations among these proteins in CRC development and progression. The protein expression of FoxM1, Cav‑1 and E‑cadherin was identified using a human CRC and normal tissue microarray. A standard immunohistochemistry assay was performed employing anti‑FoxM1, anti-Cav-1 and anti-E-cadherin antibodies. The clinicopathological significance of FoxM1, Cav‑1 and E‑cadherin in CRC was determined, and correlations were investigated between FoxM1 and Cav‑1, FoxM1 and E‑cadherin, Cav‑1 and E‑cadherin, respectively. The level of FoxM1, Cav‑1 and E‑Cadherin protein expression in CRC was found to be associated with pathological grade, tumor clinical stages and the presence of metastasis, respectively. Elevated expression of FoxM1 and Cav‑1 was observed in the CRC tissues, and a significant correlation was found between the two proteins in CRC. However, it was also observed that FoxM1 was overexpressed while E‑cadherin expression was low, indicating that there was a negative correlation between FoxM1 expression and E‑cadherin expression. Moreover, there was also a negative correlation between Cav‑1 and E‑cadherin expression. Overall, the elevated expression of FoxM1 and Cav‑1 in a human CRC microarray provided novel clinical evidence to elucidate the fact that they may play a critical role in the development and progression of CRC by negatively regulating E‑cadherin expression. Furthermore, the positive correlation between FoxM1 and Cav‑1 suggested that the proteins may constitute a novel signaling pathway in human CRC.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang J, Zhang K, Zhou L, Wu W, Jiang T, Cao J, Huang K, Qiu Z and Huang C: Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer. Oncol Lett 12: 2381-2388, 2016
APA
Zhang, J., Zhang, K., Zhou, L., Wu, W., Jiang, T., Cao, J. ... Huang, C. (2016). Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer. Oncology Letters, 12, 2381-2388. https://doi.org/10.3892/ol.2016.4915
MLA
Zhang, J., Zhang, K., Zhou, L., Wu, W., Jiang, T., Cao, J., Huang, K., Qiu, Z., Huang, C."Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer". Oncology Letters 12.4 (2016): 2381-2388.
Chicago
Zhang, J., Zhang, K., Zhou, L., Wu, W., Jiang, T., Cao, J., Huang, K., Qiu, Z., Huang, C."Expression and potential correlation among Forkhead box protein M1, Caveolin-1 and E-cadherin in colorectal cancer". Oncology Letters 12, no. 4 (2016): 2381-2388. https://doi.org/10.3892/ol.2016.4915