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Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells

  • Authors:
    • Tomohiko Fukuda
    • Katsutoshi Oda
    • Osamu Wada‑Hiraike
    • Kenbun Sone
    • Kanako Inaba
    • Yuji Ikeda
    • Chinami Makii
    • Aki Miyasaka
    • Tomoko Kashiyama
    • Michihiro Tanikawa
    • Takahide Arimoto
    • Tetsu Yano
    • Kei Kawana
    • Yutaka Osuga
    • Tomoyuki Fujii
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑8655, Japan, Department of Obstetrics and Gynecology, National Center for Global Health and Medicine, Tokyo 162‑0052, Japan
    Copyright: © Fukuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2560-2566
    |
    Published online on: August 8, 2016
       https://doi.org/10.3892/ol.2016.4978
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Abstract

Resveratrol (RSV), a polyphenolic compound derived from red wine, inhibits the proliferation of various types of cancer. RSV induces apoptosis in cancer cells, while enhancing autophagy. Autophagy promotes cancer cell growth by driving cellular metabolism, which may counteract the effect of RSV. The present study aimed to elucidate the correlation between RSV and autophagy and to examine whether autophagy inhibition may enhance the antitumor effect of RSV in endometrial cancer cells. Cell proliferation, cell cycle progression and apoptosis were examined, following RSV exposure, by performing MTT assays, flow cytometry and annexin V staining, respectively, in an Ishikawa endometrial cancer cell line. Autophagy was evaluated by measuring the expression levels of light chain 3, II (LC3‑II; an autophagy marker) by western blotting and immunofluorescence. Chloroquine (CQ) and small interfering RNAs targeting autophagy related (ATG) gene 5 (ATG5) or 7 (ATG7) were used to inhibit autophagy, and the effects in combination with RSV were assessed using MTT assays. RSV treatment suppressed cell proliferation in a dose‑dependent manner in Ishikawa cells. In addition, RSV exposure increased the abundance of the sub‑G1 population and induced apoptosis. LC3‑II accumulation was observed following RSV treatment, indicating that RSV induced autophagy. Combination treatment with CQ and RSV more robustly suppressed growth inhibition and apoptosis, compared with RSV treatment alone. Knocking down ATG5 or ATG7 expression significantly augmented RSV‑induced apoptosis. The results of the present study indicated that RSV‑induced autophagy may counteract the antitumor effect of RSV in Ishikawa cells. Combination treatment with RSV and an autophagy inhibitor, such as CQ, may be an attractive therapeutic option for treating certain endometrial cancer cells.
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View References

1 

SGO Clinical Practice Endometrial Cancer Working Group, . Burke WM, Orr J, Leitao M, Salom E, Gehrig P, Olawaiye AB, Brewer M, Boruta D, Villella J, et al: Endometrial cancer: A review and current management strategies: Part I. Gynecol Oncol. 134:385–392. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Liao C, Zhang D, Mungo C, Tompkins DA and Zeidan AM: Is diabetes mellitus associated with increased incidence and disease-specific mortality in endometrial cancer? A systematic review and meta-analysis of cohort studies. Gynecol Oncol. 135:163–171. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Renehan AG, Tyson M, Egger M, Heller RF and Zwahlen M: Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies. Lancet. 371:569–578. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Sivalingam VN, Myers J, Nicholas S, Balen AH and Crosbie EJ: Metformin in reproductive health, pregnancy and gynaecological cancer: Established and emerging indications. Hum Reprod Update. 20:853–868. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Febbraro T, Lengyel E and Romero IL: Old drug, new trick: Repurposing metformin for gynecologic cancers? Gynecol Oncol. 135:614–621. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, et al: Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:218–220. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Pendurthi UR, Williams JT and Rao LV: Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells: A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. Arterioscler Thromb Vasc Biol. 19:419–426. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, et al: Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 444:337–342. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Singh CK, Ndiaye MA and Ahmad N: Resveratrol and cancer: Challenges for clinical translation. Biochim Biophys Acta. 1852:1178–1185. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Carter LG, D'Orazio JA and Pearson KJ: Resveratrol and cancer: Focus on in vivo evidence. Endocr Relat Cancer. 21:R209–R225. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Bhat KP and Pezzuto JM: Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res. 61:6137–6144. 2001.PubMed/NCBI

12 

Kaneuchi M, Sasaki M, Tanaka Y, Yamamoto R, Sakuragi N and Dahiya R: Resveratrol suppresses growth of Ishikawa cells through down-regulation of EGF. Int J Oncol. 23:1167–1172. 2003.PubMed/NCBI

13 

Sexton E, Van Themsche C, LeBlanc K, Parent S, Lemoine P and Asselin E: Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. Mol Cancer. 5:452006. View Article : Google Scholar : PubMed/NCBI

14 

Gasparrini M, Giampieri F, Alvarez M, Suarez J, Mazzoni L, Forbes Y, Hernandez T, Quiles LJ, Bullon P and Battino M: AMPK as a new attractive therapeutic target for disease prevention: The role of dietary compounds AMPK and Disease Prevention. Curr Drug Targets. 17:865–889. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Faubert B, Vincent EE, Poffenberger MC and Jones RG: The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator. Cancer Lett. 356:165–170. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Umene K, Banno K, Kisu I, Yanokura M, Nogami Y, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, et al: New candidate therapeutic agents for endometrial cancer: Potential for clinical practice (review). Oncol Rep. 29:855–860. 2013.PubMed/NCBI

17 

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, et al: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425:191–196. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L and Gu W: Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 107:137–148. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Roth M and Chen WY: Sorting out functions of sirtuins in cancer. Oncogene. 33:1609–1620. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Borriello A, Bencivenga D, Caldarelli I, Tramontano A, Borgia A, Pirozzi AV, Oliva A and Ragione F Della: Resveratrol and cancer treatment: Is hormesis a yet unsolved matter? Curr Pharm Des. 19:5384–5393. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Opipari AW Jr, Tan L, Boitano AE, Sorenson DR, Aurora A and Liu JR: Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res. 64:696–703. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Trincheri NF, Follo C, Nicotra G, Peracchio C, Castino R and Isidoro C: Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes. Carcinogenesis. 29:381–389. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Hsu KF, Wu CL, Huang SC, Wu CM, Hsiao JR, Yo YT, Chen YH, Shiau AL and Chou CY: Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells. Autophagy. 5:451–460. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S and Auberger P: Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res. 70:1042–1052. 2010. View Article : Google Scholar : PubMed/NCBI

25 

In K, Park J and Park H: Resveratrol at high doses acts as an apoptotic inducer in endothelial cells. Cancer Res Treat. 38:48–53. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Mizushima N and Komatsu M: Autophagy: Renovation of cells and tissues. Cell. 147:728–741. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Guo JY, Xia B and White E: Autophagy-mediated tumor promotion. Cell. 155:1216–1219. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Pineda CT, Ramanathan S, Tacer K Fon, Weon JL, Potts MB, Ou YH, White MA and Potts PR: Degradation of AMPK by a cancer-specific ubiquitin ligase. Cell. 160:715–728. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Corcelle E, Djerbi N, Mari M, Nebout M, Fiorini C, Fénichel P, Hofman P, Poujeol P and Mograbi B: Control of the autophagy maturation step by the MAPK ERK and p38: Lessons from environmental carcinogens. Autophagy. 3:57–59. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Solomon VR and Lee H: Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol. 625:220–233. 2009. View Article : Google Scholar : PubMed/NCBI

31 

van der Heijden JW, Dijkmans BA, Scheper RJ and Jansen G: Drug insight: Resistance to methotrexate and other disease-modifying antirheumatic drugs-from bench to bedside. Nat Clin Pract Rheumatol. 3:26–34. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Lee SJ, Silverman E and Bargman JM: The role of antimalarial agents in the treatment of SLE and lupus nephritis. Nat Rev Nephrol. 7:718–729. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Brito-Zeron P, Sisó-Almirall A, Bové A, Kostov BA and Ramos-Casals M: Primary Sjögren syndrome: An update on current pharmacotherapy options and future directions. Expert Opin Pharmacother. 14:279–289. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Yang ZJ, Chee CE, Huang S and Sinicrope FA: The role of autophagy in cancer: Therapeutic implications. Mol Cancer Ther. 10:1533–1541. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT and White E: Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res. 17:654–666. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Fukuda T, Oda K, Wada-Hiraike O, Sone K, Inaba K, Ikeda Y, Miyasaka A, Kashiyama T, Tanikawa M, Arimoto T, et al: The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition. Gynecol Oncol. 137:538–545. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Su D, Cheng Y, Liu M, Liu D, Cui H, Zhang B, Zhou S, Yang T and Mei Q: Comparison of piceid and resveratrol in antioxidation and antiproliferation activities in vitro. PLoS One. 8:e545052013. View Article : Google Scholar : PubMed/NCBI

38 

Wu ML, Li H, Yu LJ, Chen XY, Kong QY, Song X, Shu XH and Liu J: Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PLoS One. 9:e898062014. View Article : Google Scholar : PubMed/NCBI

39 

Zhao XY, Yang S, Chen YR, Li PC, Dou MM and Zhang J: Resveratrol and arsenic trioxide act synergistically to kill tumor cells in vitro and in vivo. PLoS One. 9:e989252014. View Article : Google Scholar : PubMed/NCBI

40 

Chen S, Zhou N, Zhang Z, Li W and Zhu W: Resveratrol induces cell apoptosis in adipocytes via AMPK activation. Biochem Biophys Res Commun. 457:608–613. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Yang Q, Wang B, Zang W, Wang X, Liu Z, Li W and Jia J: Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a Sirt1-dependent manner. PLoS One. 8:e706272013. View Article : Google Scholar : PubMed/NCBI

42 

Samari HR and Seglen PO: Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem. 273:23758–23763. 1998. View Article : Google Scholar : PubMed/NCBI

43 

Miyasaka A, Oda K, Ikeda Y, Wada-Hiraike O, Kashiyama T, Enomoto A, Hosoya N, Koso T, Fukuda T, Inaba K, et al: Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells. BMC Cancer. 14:1792014. View Article : Google Scholar : PubMed/NCBI

44 

Oda K, Ikeda Y, Kawana K, Osuga Y and Fujii T: mTOR signaling in endometrial cancer: From a molecular and therapeutic point of view. Curr Obstet Gynecol Rep. 4:1–10. 2015. View Article : Google Scholar

45 

Hung CM, Garcia-Haro L, Sparks CA and Guertin DA: mTOR-dependent cell survival mechanisms. Cold Spring Harb Perspect Biol. 4(pii): a0087712012.PubMed/NCBI

46 

Li J, Qin Z and Liang Z: The prosurvival role of autophagy in resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer. 9:2152009. View Article : Google Scholar : PubMed/NCBI

47 

Filippi-Chiela EC, Villodre ES, Zamin LL and Lenz G: Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PLoS One. 6:e208492011. View Article : Google Scholar : PubMed/NCBI

48 

Tang Q, Li G, Wei X, Zhang J, Chiu JF, Hasenmayer D, Zhang D and Zhang H: Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. Cancer Lett. 336:325–337. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fukuda T, Oda K, Wada‑Hiraike O, Sone K, Inaba K, Ikeda Y, Makii C, Miyasaka A, Kashiyama T, Tanikawa M, Tanikawa M, et al: Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells. Oncol Lett 12: 2560-2566, 2016.
APA
Fukuda, T., Oda, K., Wada‑Hiraike, O., Sone, K., Inaba, K., Ikeda, Y. ... Fujii, T. (2016). Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells. Oncology Letters, 12, 2560-2566. https://doi.org/10.3892/ol.2016.4978
MLA
Fukuda, T., Oda, K., Wada‑Hiraike, O., Sone, K., Inaba, K., Ikeda, Y., Makii, C., Miyasaka, A., Kashiyama, T., Tanikawa, M., Arimoto, T., Yano, T., Kawana, K., Osuga, Y., Fujii, T."Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells". Oncology Letters 12.4 (2016): 2560-2566.
Chicago
Fukuda, T., Oda, K., Wada‑Hiraike, O., Sone, K., Inaba, K., Ikeda, Y., Makii, C., Miyasaka, A., Kashiyama, T., Tanikawa, M., Arimoto, T., Yano, T., Kawana, K., Osuga, Y., Fujii, T."Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells". Oncology Letters 12, no. 4 (2016): 2560-2566. https://doi.org/10.3892/ol.2016.4978
Copy and paste a formatted citation
x
Spandidos Publications style
Fukuda T, Oda K, Wada‑Hiraike O, Sone K, Inaba K, Ikeda Y, Makii C, Miyasaka A, Kashiyama T, Tanikawa M, Tanikawa M, et al: Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells. Oncol Lett 12: 2560-2566, 2016.
APA
Fukuda, T., Oda, K., Wada‑Hiraike, O., Sone, K., Inaba, K., Ikeda, Y. ... Fujii, T. (2016). Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells. Oncology Letters, 12, 2560-2566. https://doi.org/10.3892/ol.2016.4978
MLA
Fukuda, T., Oda, K., Wada‑Hiraike, O., Sone, K., Inaba, K., Ikeda, Y., Makii, C., Miyasaka, A., Kashiyama, T., Tanikawa, M., Arimoto, T., Yano, T., Kawana, K., Osuga, Y., Fujii, T."Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells". Oncology Letters 12.4 (2016): 2560-2566.
Chicago
Fukuda, T., Oda, K., Wada‑Hiraike, O., Sone, K., Inaba, K., Ikeda, Y., Makii, C., Miyasaka, A., Kashiyama, T., Tanikawa, M., Arimoto, T., Yano, T., Kawana, K., Osuga, Y., Fujii, T."Autophagy inhibition augments resveratrol‑induced apoptosis in Ishikawa endometrial cancer cells". Oncology Letters 12, no. 4 (2016): 2560-2566. https://doi.org/10.3892/ol.2016.4978
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