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Article

miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells

  • Authors:
    • Fang Zheng
    • Jiahe Zhang
    • Siyu Luo
    • Jing Yi
    • Ping Wang
    • Quanqing Zheng
    • Yurong Wen
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Public Health, Public Health Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Obstetrics and Gynecology, Shaanxi Tumor Hospital, Xi'an, Shaanxi 710061, P.R. China, Center for Translational Medicine, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China
  • Pages: 3021-3027
    |
    Published online on: August 16, 2016
       https://doi.org/10.3892/ol.2016.5016
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Abstract

Inappropriate expression of microRNA (miR) is strongly associated with carcinogenesis. miR-143 was reported to be one of the most prominent miRs implicated in the genesis and progression of human cancer. However, its correlation with cell proliferation and apoptosis in cervical cancer remains to be fully elucidated. In the present study, it was demonstrated that miR‑143 is able to suppress the proliferation of cervical cancer HeLa cells and induce cell apoptosis in a time‑ and dose‑dependent manner. The present study also investigated the potential targets of miR‑143, extracellular‑signal‑regulated kinase 5 (ERK5) and its downstream substrate oncoprotein c‑Fos, both of which are involved in cell proliferation and apoptosis. Upon increasing the miR-143 level, the ERK5 and c-Fos protein expression was significantly decreased without the effect of ERK5 transcription. Therefore, miR‑143 is able to suppress cell proliferation and induce apoptosis in HeLa cells, potentially through negative regulation of ERK5 at its post‑transcriptional stage.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng F, Zhang J, Luo S, Yi J, Wang P, Zheng Q and Wen Y: miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells. Oncol Lett 12: 3021-3027, 2016.
APA
Zheng, F., Zhang, J., Luo, S., Yi, J., Wang, P., Zheng, Q., & Wen, Y. (2016). miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells. Oncology Letters, 12, 3021-3027. https://doi.org/10.3892/ol.2016.5016
MLA
Zheng, F., Zhang, J., Luo, S., Yi, J., Wang, P., Zheng, Q., Wen, Y."miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells". Oncology Letters 12.4 (2016): 3021-3027.
Chicago
Zheng, F., Zhang, J., Luo, S., Yi, J., Wang, P., Zheng, Q., Wen, Y."miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells". Oncology Letters 12, no. 4 (2016): 3021-3027. https://doi.org/10.3892/ol.2016.5016
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng F, Zhang J, Luo S, Yi J, Wang P, Zheng Q and Wen Y: miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells. Oncol Lett 12: 3021-3027, 2016.
APA
Zheng, F., Zhang, J., Luo, S., Yi, J., Wang, P., Zheng, Q., & Wen, Y. (2016). miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells. Oncology Letters, 12, 3021-3027. https://doi.org/10.3892/ol.2016.5016
MLA
Zheng, F., Zhang, J., Luo, S., Yi, J., Wang, P., Zheng, Q., Wen, Y."miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells". Oncology Letters 12.4 (2016): 3021-3027.
Chicago
Zheng, F., Zhang, J., Luo, S., Yi, J., Wang, P., Zheng, Q., Wen, Y."miR‑143 is associated with proliferation and apoptosis involving ERK5 in HeLa cells". Oncology Letters 12, no. 4 (2016): 3021-3027. https://doi.org/10.3892/ol.2016.5016
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