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Article Open Access

High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer

  • Authors:
    • Xiangxiang Zheng
    • Haibo Hu
    • Shiting Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Cardiothoracic Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, Jiangsu 223300, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2357-2362
    |
    Published online on: August 16, 2016
       https://doi.org/10.3892/ol.2016.5026
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Abstract

The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in numerous diseases, and aberrant lncRNA PVT1 expression has been associated with the development of cancer. However, the underlying mechanism by which lncRNA PVT1 affects cell invasion in esophageal cancer has been not demonstrated. In the current study, the expression of lncRNA PVT1 was found to be increased in esophageal cancer specimens (n=77) by reverse transcription‑quantitative polymerase chain reaction, and was correlated with tumor stage (P=0.009) and metastasis (P<0.001). In vitro, by using transwell assay, upregulation of lncRNA PVT1 promoted the invasion of TE‑1 esophageal cancer cells; while downregulation of lncRNA PVT1 inhibited Eca‑109 cell invasion. In addition, western blot analysis indicated that upregulation of lncRNA PVT1 may induce epithelial‑to‑mesenchymal transition (EMT) by regulating the expression levels of EMT markers (E‑cadherin, N‑cadherin and vimentin). In conclusion, lncRNA PVT1 is able to regulate the invasion of esophageal cancer cells by inducing EMT.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng X, Hu H and Li S: High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer. Oncol Lett 12: 2357-2362, 2016.
APA
Zheng, X., Hu, H., & Li, S. (2016). High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer. Oncology Letters, 12, 2357-2362. https://doi.org/10.3892/ol.2016.5026
MLA
Zheng, X., Hu, H., Li, S."High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer". Oncology Letters 12.4 (2016): 2357-2362.
Chicago
Zheng, X., Hu, H., Li, S."High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer". Oncology Letters 12, no. 4 (2016): 2357-2362. https://doi.org/10.3892/ol.2016.5026
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng X, Hu H and Li S: High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer. Oncol Lett 12: 2357-2362, 2016.
APA
Zheng, X., Hu, H., & Li, S. (2016). High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer. Oncology Letters, 12, 2357-2362. https://doi.org/10.3892/ol.2016.5026
MLA
Zheng, X., Hu, H., Li, S."High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer". Oncology Letters 12.4 (2016): 2357-2362.
Chicago
Zheng, X., Hu, H., Li, S."High expression of lncRNA PVT1 promotes invasion by inducing epithelial‑to-mesenchymal transition in esophageal cancer". Oncology Letters 12, no. 4 (2016): 2357-2362. https://doi.org/10.3892/ol.2016.5026
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