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November-2016 Volume 12 Issue 5

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Regulatory network of microRNAs and genes in testicular cancer

  • Authors:
    • Yansong Zhao
    • Zhiwen Xu
    • Ning Wang
    • Shang Wang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Symbol Computation and Knowledge Engineering of The Ministry of Education, Changchun, Jilin 130012, P.R. China
  • Pages: 3640-3646
    |
    Published online on: August 24, 2016
       https://doi.org/10.3892/ol.2016.5043
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Abstract

Testicular cancer (TC) is the most common cancer in men between 20‑40 years of age. A large number of studies have focused on identifying the cause of this disease; however, the underlying regulatory mechanisms have not been thoroughly investigated and the specific cause remains unclear. The present study systematically analyzed the regulatory associations between genes, transcription factors (TFs) and microRNAs (miRNAs), aiming to obtain key information regarding the regulatory processes of TC. Three different networks were derived from the analysis: Global, related and differentially‑expressed. These networks may be able to identify the primary causes of TC through gene analysis, which determines underlying regulatory pathways and subsequently discloses information regarding TC pathology. The differentially‑expressed network is considered to be the most important. If the differentially‑expressed elements in this network were to be manipulated back to normal levels via human intervention, this may prevent the onset of TC. This may be described as suppressing TC at the genetic level. If the abnormal expression of these elements was to be corrected, then preventing TC at the source may be a feasible option. Thus, the present study compared and analyzed the global, related and differentially‑expressed networks, from which important genetic pathways in TC were highlighted. In addition, self‑adaptation associations, host genes and target genes were analyzed. The upstream and downstream elements were identified, and TFs were predicted using the P‑match method. When combined, the results of the current study provide the basic materials for further research on important genes in TC, and provide guidance on the pathological curative method.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Xu Z, Wang N and Wang S: Regulatory network of microRNAs and genes in testicular cancer. Oncol Lett 12: 3640-3646, 2016.
APA
Zhao, Y., Xu, Z., Wang, N., & Wang, S. (2016). Regulatory network of microRNAs and genes in testicular cancer. Oncology Letters, 12, 3640-3646. https://doi.org/10.3892/ol.2016.5043
MLA
Zhao, Y., Xu, Z., Wang, N., Wang, S."Regulatory network of microRNAs and genes in testicular cancer". Oncology Letters 12.5 (2016): 3640-3646.
Chicago
Zhao, Y., Xu, Z., Wang, N., Wang, S."Regulatory network of microRNAs and genes in testicular cancer". Oncology Letters 12, no. 5 (2016): 3640-3646. https://doi.org/10.3892/ol.2016.5043
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Xu Z, Wang N and Wang S: Regulatory network of microRNAs and genes in testicular cancer. Oncol Lett 12: 3640-3646, 2016.
APA
Zhao, Y., Xu, Z., Wang, N., & Wang, S. (2016). Regulatory network of microRNAs and genes in testicular cancer. Oncology Letters, 12, 3640-3646. https://doi.org/10.3892/ol.2016.5043
MLA
Zhao, Y., Xu, Z., Wang, N., Wang, S."Regulatory network of microRNAs and genes in testicular cancer". Oncology Letters 12.5 (2016): 3640-3646.
Chicago
Zhao, Y., Xu, Z., Wang, N., Wang, S."Regulatory network of microRNAs and genes in testicular cancer". Oncology Letters 12, no. 5 (2016): 3640-3646. https://doi.org/10.3892/ol.2016.5043
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