Open Access

Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN

  • Authors:
    • Hao Zhang
    • Yang Wang
    • Tianming Xu
    • Chen Li
    • Jiang Wu
    • Qianyun He
    • Guangchao Wang
    • Chen Ding
    • Kang Liu
    • Hao Tang
    • Fang Ji
  • View Affiliations

  • Published online on: August 26, 2016     https://doi.org/10.3892/ol.2016.5050
  • Pages: 3208-3214
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteosarcoma is the most common type of primary malignant bone tumor, and deregulated microRNAs (miRNAs or miRs) in osteosarcoma have attracted great attention. In the present study, through miRNA microarray analysis, it was identified that miR‑148a expression was significantly increased in osteosarcoma tissues. Increased miR‑148a expression was significantly correlated with tumor progression and prognosis. Furthermore, increased miR‑148a expression could promote osteosarcoma growth in vitro and in vivo, and the tumor‑promoting effect was due to enhanced activation of the phosphoinositide 3‑kinase signaling pathway caused by miR‑148a‑mediated inhibition of phosphatase and tensin homolog expression. Together, the present results suggest a role for miR‑148a in osteosarcoma development and its potential use in prognosis prediction and cancer therapy.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang H, Wang Y, Xu T, Li C, Wu J, He Q, Wang G, Ding C, Liu K, Tang H, Tang H, et al: Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN. Oncol Lett 12: 3208-3214, 2016
APA
Zhang, H., Wang, Y., Xu, T., Li, C., Wu, J., He, Q. ... Ji, F. (2016). Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN. Oncology Letters, 12, 3208-3214. https://doi.org/10.3892/ol.2016.5050
MLA
Zhang, H., Wang, Y., Xu, T., Li, C., Wu, J., He, Q., Wang, G., Ding, C., Liu, K., Tang, H., Ji, F."Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN". Oncology Letters 12.5 (2016): 3208-3214.
Chicago
Zhang, H., Wang, Y., Xu, T., Li, C., Wu, J., He, Q., Wang, G., Ding, C., Liu, K., Tang, H., Ji, F."Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN". Oncology Letters 12, no. 5 (2016): 3208-3214. https://doi.org/10.3892/ol.2016.5050