Open Access

HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions

  • Authors:
    • Umma Habiba
    • Tetsuya Kitamura
    • Aya Yanagawa‑Matsuda
    • Fumihiro Higashino
    • Kyoko Hida
    • Yasunori Totsuka
    • Masanobu Shindoh
  • View Affiliations

  • Published online on: August 29, 2016     https://doi.org/10.3892/ol.2016.5061
  • Pages: 3199-3207
  • Copyright: © Habiba et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The risk of malignant transformation in oral preneoplastic lesions (OPLs) is challenging to assess. The objective of the present study was to determine the expression of ELAV like RNA binding protein 1 (HuR) and podoplanin in OPLs, and to evaluate the use of each protein as biomarkers for the risk assessment of malignant transformations. Immunohistochemistry for HuR and podoplanin was performed on the tissues of 51 patients with OPL, including cases of low grade dysplasia (LGD) and high grade dysplasia (HGD). The association between the protein expression patterns and clinicopathological parameters, including oral cancer free survival (OCFS) time, was analyzed during the follow‑up period. HuR and podoplanin expression was observed in 28 (55%) and 36 (71%) of 51 patients, respectively. Kaplan‑Meier analysis showed that the expression of HuR and podoplanin was associated with the risk of progression to oral cancer (P<0.05). Multivariate analysis revealed that HuR and podoplanin expression was associated with a 2.93‑fold (95% confidence interval (CI), 0.98‑10.34; P=0.055) and 2.06‑fold (95% CI, 0.55‑8.01; P=0.283) increase in risk of malignant transformation, respectively. The risk of OPL malignant transformation was considerably increased with the coexpression of HuR and podoplanin compared with the histological grading (95% CI, 1.64‑23.59; P=0.005). The results of the present study demonstrated that the expression of HuR and podoplanin associates with malignant transformation and suggests that the proteins may be used as biomarkers to identify OPL patients with an increased risk of cancer development.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Habiba U, Kitamura T, Yanagawa‑Matsuda A, Higashino F, Hida K, Totsuka Y and Shindoh M: HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions. Oncol Lett 12: 3199-3207, 2016
APA
Habiba, U., Kitamura, T., Yanagawa‑Matsuda, A., Higashino, F., Hida, K., Totsuka, Y., & Shindoh, M. (2016). HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions. Oncology Letters, 12, 3199-3207. https://doi.org/10.3892/ol.2016.5061
MLA
Habiba, U., Kitamura, T., Yanagawa‑Matsuda, A., Higashino, F., Hida, K., Totsuka, Y., Shindoh, M."HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions". Oncology Letters 12.5 (2016): 3199-3207.
Chicago
Habiba, U., Kitamura, T., Yanagawa‑Matsuda, A., Higashino, F., Hida, K., Totsuka, Y., Shindoh, M."HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions". Oncology Letters 12, no. 5 (2016): 3199-3207. https://doi.org/10.3892/ol.2016.5061