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Article Open Access

Anti-tumoral activity of native compound morelloflavone in glioma

  • Authors:
    • Xianfeng Li
    • Hongyan Ai
    • Deke Sun
    • Tao Wu
    • Jian He
    • Zhai Xu
    • Li Ding
    • Ling Wang
  • View Affiliations / Copyright

    Affiliations: Neurosurgery Ward 2, Linyi City Yishui Central Hospital, Linyi, Shandong 276400, P.R. China, Department of Neurological Surgery Unit 1, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China, Intensive Care Unit, Linyi Municipal People's Hospital, Linyi, Shandong 276000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3373-3377
    |
    Published online on: September 5, 2016
       https://doi.org/10.3892/ol.2016.5094
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Abstract

The aim of the study was to investigate the anti-tumoral activity of morelloflavone substances with different structures. We also studied the possible link between morelloflavone structure and its function. Various types of chromatographic techniques were used to isolate and screen morelloflavone substances from the extracts of gambogic tree trunk and the morelloflavone structures were identified by analytical techniques such as high resolution mass spectrometry and nuclear magnetism. Anti-tumoral activities of different compounds were investigated and the link between the antitumor activity and the structure of compound was exaimed. Our results showed that the isolated morelloflavone substances demonstrated a certain level of antitumor activity. The compound no. 1 had the strongest effect to inhibit glioma U87 and C6 cells followed by compound no. 2 while compound no. 5 was the weakest among them. We conducted a preliminary analysis on the structure-function relationship through the structure comparison and we concluded that the antitumor effects of morelloflavone substances with different structures were significantly different from each other. Thus, the glucose chain in C4 position of biflavone structure can enhance the antitumor activity of the compound in glioma cells. Additionally, the formation of intramolecular hydrogen bonds in biflavone compounds may also play a role in enhancing the antitumor activity and inhibition rate.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Ai H, Sun D, Wu T, He J, Xu Z, Ding L and Wang L: Anti-tumoral activity of native compound morelloflavone in glioma. Oncol Lett 12: 3373-3377, 2016.
APA
Li, X., Ai, H., Sun, D., Wu, T., He, J., Xu, Z. ... Wang, L. (2016). Anti-tumoral activity of native compound morelloflavone in glioma. Oncology Letters, 12, 3373-3377. https://doi.org/10.3892/ol.2016.5094
MLA
Li, X., Ai, H., Sun, D., Wu, T., He, J., Xu, Z., Ding, L., Wang, L."Anti-tumoral activity of native compound morelloflavone in glioma". Oncology Letters 12.5 (2016): 3373-3377.
Chicago
Li, X., Ai, H., Sun, D., Wu, T., He, J., Xu, Z., Ding, L., Wang, L."Anti-tumoral activity of native compound morelloflavone in glioma". Oncology Letters 12, no. 5 (2016): 3373-3377. https://doi.org/10.3892/ol.2016.5094
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Ai H, Sun D, Wu T, He J, Xu Z, Ding L and Wang L: Anti-tumoral activity of native compound morelloflavone in glioma. Oncol Lett 12: 3373-3377, 2016.
APA
Li, X., Ai, H., Sun, D., Wu, T., He, J., Xu, Z. ... Wang, L. (2016). Anti-tumoral activity of native compound morelloflavone in glioma. Oncology Letters, 12, 3373-3377. https://doi.org/10.3892/ol.2016.5094
MLA
Li, X., Ai, H., Sun, D., Wu, T., He, J., Xu, Z., Ding, L., Wang, L."Anti-tumoral activity of native compound morelloflavone in glioma". Oncology Letters 12.5 (2016): 3373-3377.
Chicago
Li, X., Ai, H., Sun, D., Wu, T., He, J., Xu, Z., Ding, L., Wang, L."Anti-tumoral activity of native compound morelloflavone in glioma". Oncology Letters 12, no. 5 (2016): 3373-3377. https://doi.org/10.3892/ol.2016.5094
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