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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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November-2016 Volume 12 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression

  • Authors:
    • Di Han
    • Xuejuan Zhang
    • Jietao Zhang
    • Xiaozi Guo
    • Yu Zheng
    • Shihua Sui
    • Jiaping Zheng
  • View Affiliations / Copyright

    Affiliations: Department of General Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266031, P.R. China, Department of Neurology, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China
  • Pages: 3519-3522
    |
    Published online on: September 6, 2016
       https://doi.org/10.3892/ol.2016.5096
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Abstract

Arteriosclerosis poses a significant risk to human health and involves the thickening and hardening of the walls of arteries. Accumulated evidence demonstrates that aberrant proliferation of vascular smooth muscle cells (VSMCs) accounts for the onset and progression of arteriosclerosis. Suppression of their proliferation has been demonstrated to be an effective anti‑arteriosclerosis strategy. Long non‑coding RNAs (lncRNAs) have recently been observed to be implicated in the proliferation of VSMCs and arteriosclerosis. In this study, we observed that oleanolic acid (OA), a natural compound from plants, inhibited the proliferation of VSMCs. The expression of lincRNA‑p21, an arteriosclerosis‑associated lncRNA, was demonstrated to be elevated by OA treatment. Suppression of lincRNA‑p21 rescued the effect of OA on the proliferation of VSMCs. Collectively, targeting lncRNA is a promising strategy for arteriosclerosis prevention and treatment, and OA ameliorates arteriosclerosis by increasing lncRNA levels.
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Copy and paste a formatted citation
Spandidos Publications style
Han D, Zhang X, Zhang J, Guo X, Zheng Y, Sui S and Zheng J: Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression. Oncol Lett 12: 3519-3522, 2016.
APA
Han, D., Zhang, X., Zhang, J., Guo, X., Zheng, Y., Sui, S., & Zheng, J. (2016). Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression. Oncology Letters, 12, 3519-3522. https://doi.org/10.3892/ol.2016.5096
MLA
Han, D., Zhang, X., Zhang, J., Guo, X., Zheng, Y., Sui, S., Zheng, J."Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression". Oncology Letters 12.5 (2016): 3519-3522.
Chicago
Han, D., Zhang, X., Zhang, J., Guo, X., Zheng, Y., Sui, S., Zheng, J."Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression". Oncology Letters 12, no. 5 (2016): 3519-3522. https://doi.org/10.3892/ol.2016.5096
Copy and paste a formatted citation
x
Spandidos Publications style
Han D, Zhang X, Zhang J, Guo X, Zheng Y, Sui S and Zheng J: Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression. Oncol Lett 12: 3519-3522, 2016.
APA
Han, D., Zhang, X., Zhang, J., Guo, X., Zheng, Y., Sui, S., & Zheng, J. (2016). Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression. Oncology Letters, 12, 3519-3522. https://doi.org/10.3892/ol.2016.5096
MLA
Han, D., Zhang, X., Zhang, J., Guo, X., Zheng, Y., Sui, S., Zheng, J."Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression". Oncology Letters 12.5 (2016): 3519-3522.
Chicago
Han, D., Zhang, X., Zhang, J., Guo, X., Zheng, Y., Sui, S., Zheng, J."Oleanolic acid suppresses vascular smooth muscle cell proliferation by increasing lincRNA-p21 expression". Oncology Letters 12, no. 5 (2016): 3519-3522. https://doi.org/10.3892/ol.2016.5096
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