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Article Open Access

Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays

  • Authors:
    • Xin Jin
    • Dongjuan Liu
    • Xin Zhao
    • Yu Zhou
    • Lu Jiang
    • Jing Li
    • Xin Zeng
    • Qianming Chen
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3175-3182
    |
    Published online on: September 12, 2016
       https://doi.org/10.3892/ol.2016.5120
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Abstract

The aim of this study was to evaluate clinicopathological risk factors associated with the fatal outcome of oral squamous cell carcinoma (OSCC) in a large cohort of Chinese patients, and to construct tissue microarrays (TMAs) using this cohort. Univariate and multiple logistic regression analyses were performed to evaluate the predictors of poor prognosis in a cohort of 232 patients with OSCC, after which the patient tumor tissues were used to construct TMAs. Univariate logistic regression analysis indicated that a poor outcome of OSCC was associated with the male gender, a history of smoking, the tumor‑node‑metastasis stage and lymph node metastasis. Multiple logistic regression analysis demonstrated that an increased risk of mortality in patients with OSCC was significantly and independently associated with lymph node metastasis (odds ratio, 3.421; 95% confidence interval, 1.609‑7.273). Therefore, the results of the present study suggested that lymph node metastasis is an independent risk factor associated with a poor prognosis of OSCC patients. TMAs of OSCC were successfully constructed, and are the first TMAs to be reported in mainland Chinese patients.
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Copy and paste a formatted citation
Spandidos Publications style
Jin X, Liu D, Zhao X, Zhou Y, Jiang L, Li J, Zeng X and Chen Q: Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays. Oncol Lett 12: 3175-3182, 2016.
APA
Jin, X., Liu, D., Zhao, X., Zhou, Y., Jiang, L., Li, J. ... Chen, Q. (2016). Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays. Oncology Letters, 12, 3175-3182. https://doi.org/10.3892/ol.2016.5120
MLA
Jin, X., Liu, D., Zhao, X., Zhou, Y., Jiang, L., Li, J., Zeng, X., Chen, Q."Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays". Oncology Letters 12.5 (2016): 3175-3182.
Chicago
Jin, X., Liu, D., Zhao, X., Zhou, Y., Jiang, L., Li, J., Zeng, X., Chen, Q."Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays". Oncology Letters 12, no. 5 (2016): 3175-3182. https://doi.org/10.3892/ol.2016.5120
Copy and paste a formatted citation
x
Spandidos Publications style
Jin X, Liu D, Zhao X, Zhou Y, Jiang L, Li J, Zeng X and Chen Q: Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays. Oncol Lett 12: 3175-3182, 2016.
APA
Jin, X., Liu, D., Zhao, X., Zhou, Y., Jiang, L., Li, J. ... Chen, Q. (2016). Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays. Oncology Letters, 12, 3175-3182. https://doi.org/10.3892/ol.2016.5120
MLA
Jin, X., Liu, D., Zhao, X., Zhou, Y., Jiang, L., Li, J., Zeng, X., Chen, Q."Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays". Oncology Letters 12.5 (2016): 3175-3182.
Chicago
Jin, X., Liu, D., Zhao, X., Zhou, Y., Jiang, L., Li, J., Zeng, X., Chen, Q."Analysis of clinicopathological characteristics associated with the outcome of oral squamous cell carcinoma and the establishment of tissue microarrays". Oncology Letters 12, no. 5 (2016): 3175-3182. https://doi.org/10.3892/ol.2016.5120
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