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High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer

  • Authors:
    • Ying Liu
    • Yu Zhang
    • Ying Zhao
    • Dongna Gao
    • Jing Xing
    • Hui Liu
  • View Affiliations / Copyright

    Affiliations: Emergency Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3825-3835
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    Published online on: September 22, 2016
       https://doi.org/10.3892/ol.2016.5169
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Abstract

Poly (adenosine diphosphate‑ribose) polymerase 1 (PARP-1) was previously demonstrated to be overexpressed in numerous malignant tumors and associated with invasiveness and poor prognosis. However, the expression of the PARP‑1 protein in gastric cancer and its association with clinical outcomes requires further investigation. In the present study, the expression of PARP‑1 in 564 gastric cancer tissues and 335 tumor‑adjacent control tissues is investigated, using tissue microarray‑based immunohistochemistry. PARP‑1 expression levels were demonstrated to be significantly higher in gastric cancer tissue samples, as compared with control tissue samples. In gastric cancer, high PARP‑1 expression levels were significantly associated with Helicobacter pylori (H. pylori) infection (P=0.032), decreased differentiation (P<0.001), increased depth of invasion (P=0.037), presence of lymphatic invasion (P<0.001), presence of lymph node metastasis (P<0.001), and advanced tumor‑node‑metastasis (TNM) stage (P=0.015). High PARP‑1 expression levels were associated with a significantly shorter overall survival rate (P<0.001) and disease‑free survival rate (P=0.001) in patients with gastric cancer, particularly a subset of patients with H. pylori infection or an advanced TNM stage. In addition, univariate analysis indicated that PARP‑1 high expression levels were significantly associated with a poor prognosis in gastric cancer. These results suggest that PARP‑1 expression may be involved in the progression and prognosis of gastric cancer, particularly H. pylori‑positive or advanced‑stage gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Zhang Y, Zhao Y, Gao D, Xing J and Liu H: High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. Oncol Lett 12: 3825-3835, 2016.
APA
Liu, Y., Zhang, Y., Zhao, Y., Gao, D., Xing, J., & Liu, H. (2016). High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. Oncology Letters, 12, 3825-3835. https://doi.org/10.3892/ol.2016.5169
MLA
Liu, Y., Zhang, Y., Zhao, Y., Gao, D., Xing, J., Liu, H."High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer". Oncology Letters 12.5 (2016): 3825-3835.
Chicago
Liu, Y., Zhang, Y., Zhao, Y., Gao, D., Xing, J., Liu, H."High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer". Oncology Letters 12, no. 5 (2016): 3825-3835. https://doi.org/10.3892/ol.2016.5169
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Zhang Y, Zhao Y, Gao D, Xing J and Liu H: High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. Oncol Lett 12: 3825-3835, 2016.
APA
Liu, Y., Zhang, Y., Zhao, Y., Gao, D., Xing, J., & Liu, H. (2016). High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer. Oncology Letters, 12, 3825-3835. https://doi.org/10.3892/ol.2016.5169
MLA
Liu, Y., Zhang, Y., Zhao, Y., Gao, D., Xing, J., Liu, H."High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer". Oncology Letters 12.5 (2016): 3825-3835.
Chicago
Liu, Y., Zhang, Y., Zhao, Y., Gao, D., Xing, J., Liu, H."High PARP-1 expression is associated with tumor invasion and poor prognosis in gastric cancer". Oncology Letters 12, no. 5 (2016): 3825-3835. https://doi.org/10.3892/ol.2016.5169
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