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Article Open Access

Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins

  • Authors:
    • Xiao‑Man Xu
    • Man‑Li Zhang
    • Yi Zhang
    • Li Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3779-3784
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    Published online on: September 22, 2016
       https://doi.org/10.3892/ol.2016.5170
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Abstract

In the present study, we investigated the effects and mechanisms of Osthole on the apoptosis of non‑small cell lung cancer (NSCLC) cells and its synergistic effect with Embelin. Our results revealed that treatment with both Osthole and Embelin inhibited cell proliferation. Notably, combination treatment of Osthole and Embelin inhibited cell proliferation more significantly compared with monotherapy. In addition, morphological analysis and Annexin V/propidium iodide analysis revealed that the combination of Osthole and Embelin enhanced their effect on cell apoptosis. We further examined the effect of Osthole on the expression of inhibitor of apoptosis protein (IAP) family proteins. That treatment of A549 lung cancer cells with various concentrations of Osthole was observed to decrease the protein expression of X‑chromosome‑encoded IAP, c‑IAP1, c‑IAP2 and Survivin, and increase Smac expression in a dose‑dependent manner. Furthermore, it was noted that Osthole or Embelin alone increased the expression of BAX, caspase‑3, caspase‑9, cleaved caspase‑3 and cleaved caspase‑9, and decreased Bcl‑2 levels following treatment. Osthole and Embelin combination treatment had a synergistic effect on the regulation of these proteins. In conclusion, our study demonstrated that Osthole inhibited proliferation and induced the apoptosis of lung cancer cells via IAP family proteins in a dose‑dependent manner. Osthole enhances the antitumor effect of Embelin, indicating that combination of Osthole and Embelin has potential clinical significance in the treatment of NSCLC.
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View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J and Johnson DH: Eastern Cooperative Oncology Group: Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 346:92–98. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Pérez-Soler R: Individualized therapy in non-small-cell lung cancer: future versus current clinical practice. Oncogene. 28(Suppl 1): S38–S45. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Igney FH and Krammer PH: Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer. 2:277–288. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Los M, Burek CJ, Stroh C, Benedyk K, Hug H and Mackiewicz A: Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design. Drug Discov Today. 8:67–77. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Reed JC: Apoptosis-based therapies. Nat Rev Drug Discov. 1:111–121. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Liao PC, Chien SC, Ho CL, Wang EI, Lee SC, Kuo YH, Jeyashoke N, Chen J, Dong WC, Chao LK and Hua KF: Osthole regulates inflammatory mediator expression through modulating NF-κB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species. J Agric Food Chem. 58:10445–10451. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Liu JH, Zschocke S, Reininger E and Bauer R: Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. Planta Med. 64:525–529. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Matsuda H, Tomohiro N, Ido Y and Kubo M: Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol Pharm Bull. 25:809–812. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Liu WB, Zhou J, Qu Y, Li X, Lu CT, Xie KL, Sun XL and Fei Z: Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production. Neurochem Int. 57:206–215. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Kuo PL, Hsu YL, Chang CH and Chang JK: Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells. J Pharmacol Exp Ther. 314:1290–1299. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Huang RL, Chen CC, Huang YL, Hsieh DJ, Hu CP, Chen CF and Chang C: Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro. Hepatology. 24:508–515. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Yang LL, Wang MC, Chen LG and Wang CC: Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. Planta Med. 69:1091–1095. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Chou SY, Hsu CS, Wang KT, Wang MC and Wang CC: Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study. Phytother Res. 21:226–230. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Riviere C, Goossens L, Pommery N, Fourneau C, Delelis A and Henichart JP: Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker. Nat Prod Res. 20:909–916. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Deveraux QL and Reed JC: IAP family proteins - suppressors of apoptosis. Genes Dev. 13:239–252. 1999. View Article : Google Scholar : PubMed/NCBI

17 

LaCasse EC, Baird S, Korneluk RG and MacKenzie AE: The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene. 17:3247–3259. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Deveraux QL, Takahashi R, Salvesen GS and Reed JC: X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 388:300–304. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Roy N, Deveraux QL, Takahashi R, Salvesen GS and Reed JC: The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16:6914–6925. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Salvesen GS and Duckett CS: IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 3:401–410. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Liston P, Fong WG and Korneluk RG: The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene. 22:8568–8580. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Nachmias B, Ashhab Y and Ben-Yehuda D: The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer. Semin Cancer Biol. 14:231–243. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Tamm I, Kornblau SM, Segall H, Krajewski S, Welsh K, Kitada S, Scudiero DA, Tudor G, Qui YH, Monks A, et al: Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res. 6:1796–1803. 2000.PubMed/NCBI

24 

Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ and Barker PA: cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell. 30:689–700. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Chitra M, Sukumar E, Suja V and Devi CS: Antitumor, anti-inflammatory and analgesic property of embelin, a plant product. Chemotherapy. 40:109–113. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Nikolovska-Coleska Z, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, et al: Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 47:2430–2440. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk RG, Durkin JP, Mayer LD and LaCasse EC: Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res. 9:2826–2836. 2003.PubMed/NCBI

28 

Asselin E, Mills GB and Tsang BK: XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res. 61:1862–1868. 2001.PubMed/NCBI

29 

Lu J, Huang Y, Zhao W, Marquez RT, Meng X, Li J, Gao X, Venkataramanan R, Wang Z and Li S: PEG-derivatized embelin as a nanomicellar carrier for delivery of paclitaxel to breast and prostate cancers. Biomaterials. 34:1591–1600. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Yang D, Gu T, Wang T, Tang Q and Ma C: Effects of osthole on migration and invasion in breast cancer cells. Biosci Biotechnol Biochem. 74:1430–1434. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Tsai CF, Yeh WL, Chen JH, Lin C, Huang SS and Lu DY: Osthole suppresses the migratory ability of human glioblastoma multiforme cells via inhibition of focal adhesion kinase-mediated matrix metalloproteinase-13 expression. Int J Mol Sci. 15:3889–3903. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Okamoto T, Kobayashi T and Yoshida S: Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas. Curr Med Chem Anticancer Agents. 5:47–51. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Xu XM, Zhang Y, Qu D, Feng XW, Chen Y and Zhao L: Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro. Mol Med Rep. 6:1018–1022. 2012.PubMed/NCBI

34 

Xu X, Zhang Y, Qu D, Jiang T and Li S: Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. J Exp Clin Cancer Res. 30:332011. View Article : Google Scholar : PubMed/NCBI

35 

Xu XM, Zhang Y, Qu D, Liu HB, Gu X, Jiao GY and Zhao L: Combined anticancer activity of osthole and cisplatin in NCI-H460 lung cancer cells in vitro. Exp Ther Med. 5:707–710. 2013.PubMed/NCBI

36 

Duckett CS, Nava VE, Gedrich RW, Clem RJ, Van Dongen JL, Gilfillan MC, Shiels H, Hardwick JM and Thompson CB: A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J. 15:2685–2694. 1996.PubMed/NCBI

37 

Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y and Alnemri ES: A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 410:112–116. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC and Fesik SW: Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 408:1004–1008. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Eckelman BP, Drag M, Snipas SJ and Salvesen GS: The mechanism of peptide-binding specificity of IAP BIR domains. Cell Death Differ. 15:920–928. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Tenev T, Zachariou A, Wilson R, Ditzel M and Meier P: IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat Cell Biol. 7:70–77. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Huang HK, Joazeiro CA, Bonfoco E, Kamada S, Leverson JD and Hunter T: The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. J Biol Chem. 275:26661–26664. 2000.PubMed/NCBI

42 

Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM and Bratton SB: The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and −7 via unique mechanisms at distinct steps in their processing. J Biol Chem. 284:12772–12782. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Samuel T, Okada K, Hyer M, Welsh K, Zapata JM and Reed JC: cIAP1 localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 65:210–218. 2005.PubMed/NCBI

44 

Imoto I, Tsuda H, Hirasawa A, Miura M, Sakamoto M, Hirohashi S and Inazawa J: Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res. 62:4860–4866. 2002.PubMed/NCBI

45 

Tanimoto T, Tsuda H, Imazeki N, Ohno Y, Imoto I, Inazawa J and Matsubara O: Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas. Cancer Lett. 224:141–151. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Che X, Yang D, Zong H, Wang J, Li X, Chen F, Chen X and Song X: Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients. Urol Oncol. 30:450–456. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Yang L, Mashima T, Sato S, Mochizuki M, Sakamoto H, Yamori T, Oh-Hara T and Tsuruo T: Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res. 63:831–837. 2003.PubMed/NCBI

48 

Danquah M, Li F, Duke CB III, Miller DD and Mahato RI: Micellar delivery of bicalutamide and embelin for treating prostate cancer. Pharm Res. 26:2081–2092. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Sreepriya M and Bali G: Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats. Fitoterapia. 76:549–555. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Dai Y, Qiao L, Chan KW, Yang M, Ye J, Ma J, Zou B, Gu Q, Wang J, Pang R, et al: Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis. Cancer Res. 69:4776–4783. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Heo JY, Kim HJ, Kim SM, Park KR, Park SY, Kim SW, Nam D, Jang HJ, Lee SG, Ahn KS, et al: Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN. Cancer Lett. 308:71–80. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Avisetti DR, Babu KS and Kalivendi SV: Activation of p38/JNK pathway is responsible for embelin induced apoptosis in lung cancer cells: transitional role of reactive oxygen species. PloS One. 9:e870502014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu XM, Zhang ML, Zhang Y and Zhao L: Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins. Oncol Lett 12: 3779-3784, 2016.
APA
Xu, X., Zhang, M., Zhang, Y., & Zhao, L. (2016). Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins. Oncology Letters, 12, 3779-3784. https://doi.org/10.3892/ol.2016.5170
MLA
Xu, X., Zhang, M., Zhang, Y., Zhao, L."Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins". Oncology Letters 12.5 (2016): 3779-3784.
Chicago
Xu, X., Zhang, M., Zhang, Y., Zhao, L."Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins". Oncology Letters 12, no. 5 (2016): 3779-3784. https://doi.org/10.3892/ol.2016.5170
Copy and paste a formatted citation
x
Spandidos Publications style
Xu XM, Zhang ML, Zhang Y and Zhao L: Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins. Oncol Lett 12: 3779-3784, 2016.
APA
Xu, X., Zhang, M., Zhang, Y., & Zhao, L. (2016). Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins. Oncology Letters, 12, 3779-3784. https://doi.org/10.3892/ol.2016.5170
MLA
Xu, X., Zhang, M., Zhang, Y., Zhao, L."Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins". Oncology Letters 12.5 (2016): 3779-3784.
Chicago
Xu, X., Zhang, M., Zhang, Y., Zhao, L."Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins". Oncology Letters 12, no. 5 (2016): 3779-3784. https://doi.org/10.3892/ol.2016.5170
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